Weill Cornell Medicine’s Post

Gain Therapeutics Presents Preclinical GT-02287 Data at Neuroscience 2024 GT-02287 Demonstrates Disease Modifying Capacity in Both GBA1 and Idiopathic Parkinson’s Disease Models GT-02287 Improves Mitochondrial Function and Provides Neuroprotective Effect in GBA1-Parkinson’s Disease Models GT-02287 Prevents Tau Accumulation in a Cellular Model https://lnkd.in/gNiWjrb9

In a recent interview, Nigel Bunnett, PhD, BSc, of NYU Langone Health, provided a clinical overview of preclinical research identifying a new receptor for nerve growth factor that plays an important role in pain signaling. https://lnkd.in/eTepfSrw

📢📢 International Pharmaco-EEG Society Conference (IPEG) 2024: Meet SynapCell’s scientists in Izmir, Turkey, from November 21 to 24, 2024. Let’s discuss Science and explore how #preclinical #EEG can accelerate #CNS drug discovery. Our team will be presenting two posters: 👉Direct Electrical Stimulation to Assess Brain Excitability & Connectivity, presented by Eloïse GRONLIER, Research Engineer 👉Standardized Pharmaco-Sleep-Electroencephalography as a Preclinical Tool for Antidepressant Drug Profiling, presented by Chloé Habermacher, Principal Scientist #Epilepsy #Parkinson #EssentialTremor #autism #Schizophrenia #anxiety

Evaluating how salivary extracellular vesicle isolation methods influence biomarker detection: in their latest work, Jeremy Boulestreau, Malik Kahli at CNRS and collaborators compared salivary EVs isolated using two scalable techniques, co-precipitation and immuno-affinity, against the gold-standard ultracentrifugation. Through cryo-electron microscopy (Cryo-EM), Nanoparticle Tracking Analysis, Western Blots, and proteomics, they revealed significant method-dependent differences in EV size, concentration, and protein content. Notably, their study demonstrated the unique capability of EV isolation to detect specific biomarkers that remain undetectable in whole saliva via WB. RT-qPCR targeting six miRNAs confirmed consistent enrichment of these miRNAs in EV-derived cargo across all three methods https://lnkd.in/ebJxEDZE Additionally, they discovered that pre-filtering saliva samples with 0.22 or 0.45 µm filters negatively impacts downstream analyses. This research highlights an underexplored EV source and sets the stage for its integration into routine clinical diagnostics. An article co-authored by Laurence Molina, Alimata Ouedraogo, Louën Laramy, Ines Grich, Thi Nhu Ngoc Van and Franck Molina #extracellularvesicles #exosomes #diagnostics #miRNA #Vesiculab

A very nice review (open access) by T. Morisaki and Tim Stasevich of the latest developments in the field of single-molecule detection of translation in living cells. #mRNA #Translation #smFISH #livecell #imaging https://lnkd.in/eREkq6AF Translation Dynamics of Single mRNAs in Live Cells | Annual Reviews The importance of fundamental research to understand the complexity of translational regulation in order to produce new therapeutics in the coming years!

Identification of Mitochondrial Exosome as an Escape Mechanism of Mitochondrial DNA in a Cardiac in vitro Model of Lipotoxicity Mónica Malú Velásquez Esparza, Escuela de Medicina del Tecnológico de Monterrey, Mexico, shared interesting research on the role of mitochondrial exosomes as an escape mechanism for mitochondrial DNA under lipotoxic conditions in a cardiac in vitro model at #TargetingEVs2024. This study reveals potential therapeutic targets for addressing lipotoxicity-related cardiac damage. #TargetingEVs #mitovesicles #microvesicles #extracellularvesicles #mitochondria #exosomes #lipotoxicity

Agena is excited to announce that Lin Wang, MD, MS, will be sharing insights on the validation and implementation of a thrombosis risk factor assay at Stanford Medicine, leveraging the high throughput genotyping capabilities of the MassARRAY® System.     Check out the poster session at this year’s AMP Annual Meeting (Nov 19-23): TT028: Implementation and Validation of a Thrombosis Risk Factor Assay with the MassARRAY System. The authors discuss the implementation of the assay in their lab and compare the mass-spectrometry-based MassARRAY assay to a fluorescence resonance energy transfer (FRET)-based assay.     Leave a comment below if you are interested in finding out more about the study results, and how Agena can help you develop reliable, cost-effective assays for research on thrombotic risk factors or other areas of interest in genomic research. 

In the process of tumor research, biological samples such as tissues, cell extracts, and blood often need to be processed and concentrated for subsequent analysis and experiments. The vacuum centrifuge concentrator effectively removes solvents from liquid samples through centrifugal action and vacuum operation, achieving sample concentration. This concentration process increases the sample's concentration, facilitating subsequent experiments, such as proteomic and metabolomic analyses.

𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝗳𝘂𝗹 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵 𝗼𝗻 𝗥𝗲𝘀𝘁𝗼𝗿𝗶𝗻𝗴 𝗩𝗶𝘀𝗶𝗼𝗻 𝗧𝗵𝗿𝗼𝘂𝗴𝗵 𝗢𝗽𝘁𝗼𝗴𝗲𝗻𝗲𝘁𝗶𝗰𝘀  👁️✨ Link in the first comment! 👇 How can 𝗼𝗽𝘁𝗼𝗴𝗲𝗻𝗲𝘁𝗶𝗰𝘀 help restore vision in cases of retinal degeneration? Qi Lu, Anna Wright & Pan Zhuo-Hua, from Wayne State University, studied the effects of AAV dose on retinal ganglion cells (RGCs) and efficacy of optogenetic vision restoration. This preclinical study, published in 𝘎𝘦𝘯𝘦 𝘛𝘩𝘦𝘳𝘢𝘱𝘺, provides important insights into potential therapies to restore vision in patients affected by blindness. We’re proud that Striatech’s 𝗢𝗽𝘁𝗼𝗗𝗿𝘂𝗺 𝗱𝗲𝘃𝗶𝗰𝗲  played a role in this cutting-edge research, enabling precise measurements of visual function after restoring vision. 🔬 Curious to learn more? Read our latest blog article to explore the study and its implications for optogenetic vision restoration. #Optogenetics #VisionRestoration #GeneTherapy #Striatech #InnovationInResearch