WGN Radio AM 720’s Post

Mastitis caused by Gram-negative bacteria can be elusive and cause trouble down the line, leading to aggressive treatment, spread of mastitis pathogens and delayed return to the milking parlor. The University of California, Davis published a study in the Journal of Dairy Science in 2023, that demonstrated how ceftiofur hydrochloride was effective in improving bacteriological and clinical cures, lowering mastitis recurrence, reducing use of supplemental therapy and minimizing mastitis-related culls and deaths. Joining us to tell us more is Dr. Juan Rodrigo Pedraza, Managing Director with Zoetis.

Exciting update from our lab!   We're thrilled to share our latest findings on Fitodenta Oromucosal Relief Spray's ability to fight off Staphylococcus aureus ATCC6538. 🦠 Our study involved thorough testing, including three separate rounds of experiments. 🔍According to CLSI M45 guidelines, our results show that FITODENTA OROMUCOSAL RELIEF SPRAY can effectively combat Staphylococcus aureus, with the highest dilution still inhibiting its growth up to a factor of 1:8. 📊 This means it's potent against these bacteria.   Learn more about our groundbreaking study and its implications in the fight against microbial challenges: https://lnkd.in/dkWv5j8B   #AntimicrobialResearch #Fitodenta #OralHealth #MIC #StaphylococcusAureus #Innovation #Science #Research #Healthcare#MedicalScience

Our collaboration with NOxy Health Products has yielded groundbreaking insights into the efficacy of acidified nitrite foam (ANF) in combating microbial pathogens. The study's clinical implications are significant, positioning #ANF as a potent antimicrobial agent against various biofilms. Explore the full paper here: https://bit.ly/3S35YAm

Exciting expansion as SpeeDx adds concise gastroenteritis panels to their Research offerings. EntericPlex* products Sharpen Your Focus. Research relevant pathogens | Maximize efficiency with focused enteric panels. US based — https://lnkd.in/gn4Qz7rv Not US based — https://lnkd.in/gFHAagyv Read Press Release https://lnkd.in/gUT-Vd9i *EntericPlex Product are Research Use Only, not for use in diagnostic procedures

All individuals involved in bacterial resistance and efflux pumps research must register for the upcoming webinar. Permeability barriers work in conjunction with efflux pumps to provide bacteria with resistance against antibiotics. Discuss the strategic targeting of these pumps as a potential solution to combat multidrug resistance that you participate in to stay updated with the latest advancements in this field.

Discover the fundamentals of biofilms and how they impact food processing facilities in our upcoming #webinar. Learn from experts about genetic changes, antimicrobial resistance, and methods to mitigate biofilm formation. Register Now: https://brnw.ch/21wLVLw

Novel #scientificdiscoveries await you with our NEW #ProteinDiscoveryCatalog! You can search by disease association, reactome pathways, protein name, Uniprot keyword, and more to discover #biomarkerassociations, layer new information onto #genomicsdata, and enrich your biological understanding. https://bit.ly/3SvmtGV #proteomicsresearch #proteomicsdiscovery #proteomicsanalysis #proteomicsworkflows #biomarkerdiscovery #Seerstudies #ProteographXT #OrbitrapAstralMassSpec

Relavant insights for those in my network working on Target IDs with TPD.

Nice work Vesna and the CeTPD/BI teams to highlight some traps that everyone who is looking for new degraders should be aware of! Some key takeaways: ·     Degrading proteins with intrinsic half-lives of 2hrs or shorter is more difficult (though far from impossible) ·     Beware that HiBit-tagged proteins can have shorter half-lives and so may be more difficult to degrade than endogenous targets, underestimating DC50. ·     Slow onset degradation, especially of short-lived proteins, can often indicate an indirect mechanism eg via inhibition of protein synthesis (via GSPT1 degradation – best check for this if you’re using CRBN-based degraders) ·     Cytotoxic compounds can also give apparent degradation, even if the cytotoxicity is not apparent at say 24h so make sure you have a large window between DC50 and cell tox IC50 ·     These “indirect” (ie undesirable) mechanisms of degradation will still look well behaved with some of the usual controls (addition of proteasome inhibitor, NEDDylation inhibitor) – instead a better control is to add free PoI ligand which should abrogate well-behaved degradation. ·     If you see literature reports of degraders of c-myc (half-life ~20mins), be very sceptical until you see all the controls and proteomic selectivity….

Our latest mycotoxin publication: Advancing Mycotoxin Detection in Food & Feed: Novel Insights from Surface-Enhanced Raman Spectroscopy https://lnkd.in/gvwU8vrT