WuXi XDC’s Post

As protein production experts, we often get questions about the potential risks involved in switching the production host from HEK293 cells to CHO cells for therapeutic antibody production. We’re happy to share our insights here! Potential risks include titer variations, different glycosylation patterns, other post-translational modifications (PTMs), and occasional protein truncations. These differences may lead to inconsistent efficacy, pharmacokinetics (PK), and challenges in CMC as well as late-stage development. For therapeutic molecules, it’s highly recommended to use the same CHO host from early discovery to commercial manufacturing to ensure consistency and reliability. Want to learn more? Check out the FAQs at the end of our antibody production webpage: ▶️https://lnkd.in/eZ4SAiiX #proteinproduction #glycosylation #drugdevolopment #pharmacokinetics #antibodyproduction

Do you know about Bispecific ADCs (BsADCs)? They are a promising new bioconjugated modality which capitalize on the advantages of Bispecific mAbs when it comes to ADC’s challenges with drug resistance, poor internalization, or off-target specificity. Read this review to learn about strategies and considerations to optimize the development of novel BsADCs. See publication: https://lnkd.in/e3JgqfV9

Combining the power of ADCs with the advantages of bispecifics, Bispecific ADCs are definitely a new modality I am excited to watch out for! #drugdiscovery #drugdevelopment #antibodytherapeutics

Q2 Promo: Purchase any size cap analog from Areterna and receive free NTPs. Please click the link to find the terms and conditions: https://lnkd.in/d_JQ8bb3 Why choose our novel cap analogs: ✔ Better Protein Expression – based on our data, our novel cap5 has significantly higher protein expression than other generations of cap analogs. ✔ License Free – avoid royalty fees associated with proprietary mRNA raw materials. ✔ Cost Effective – offered at a competitive price to enable wider adoption of mRNA as vaccines and therapeutics. ✔ GMP Grade Available – our cap analogs are available in GMP grade per request. #mRNA #capanalogs #NTPs

Proximity labelling approach——#TurboID Biotin proximity labeling is a technique based on the TurboID #enzyme that can be used to capture weak or dynamic interactions of proteins that were not previously used to interact with specific DNA sequences. TurboID is one of the most efficient #biotin ligases that can effectively label several proteins within a 10 nm labeling radius in mammalian cells. A study conducted by Zhang Y. et al. from University of California, have successfully applied proximity labeling to interacting protein against tobacco mosaic virus (TMV) immune receptor protein N, and identified a novel #regulator UBR 7 that can directly interact with NNLR and mediate its turnover during N protein-mediated TMV resistance. Reference: Zhang Y., Song G., Lal N.K., et al. TurboID-based proximity labeling reveals that UBR7 is a regulator of N NLR immune receptor-mediated immunity. Nat Commun. 2019, 10(1): 3252. #pharmaceutical #research #ligase #ligand #tpd #proteindegradation #degrader #molecularglues

🔎Did you know that 𝙥𝙃 and 𝙩𝙝𝙚𝙧𝙢𝙖𝙡 𝙙𝙚𝙜𝙧𝙖𝙙𝙖𝙩𝙞𝙤𝙣 can significantly impact the quality attributes of monoclonal antibodies (#mAbs)? 💡 In the following study, Victor A. Beaumont and his team explore the use of advanced analytical techniques to investigate changes in the structure of monoclonal antibodies under different stress conditions. 🎯 𝙎𝙣𝙞𝙥𝙥𝙚𝙩 𝙃𝙞𝙜𝙝𝙡𝙞𝙜𝙝𝙩𝙨: 🌏 The study focused on understanding changes in the structure of antibodies under different stress conditions, such as 𝙥𝙃 and 𝙩𝙝𝙚𝙧𝙢𝙖𝙡 𝙙𝙚𝙜𝙧𝙖𝙙𝙖𝙩𝙞𝙤𝙣. 🌎 Samples of #𝒂𝒅𝒂𝒍𝒊𝒎𝒖𝒎𝒂𝒃 and #𝒕𝒓𝒂𝒔𝒕𝒖𝒛𝒖𝒎𝒂𝒃 were subjected to analysis, revealing significant differences in their spectra. 🌍 𝑨𝒅𝒂𝒍𝒊𝒎𝒖𝒎𝒂𝒃 showed minor changes in spectra after forced degradation, while 𝒕𝒓𝒂𝒔𝒕𝒖𝒛𝒖𝒎𝒂𝒃 exhibited significant differences. 🌏 Chemometric tools like #PROFILE, #PCA, and #ECHOS were employed for faster and more precise data interpretation. 🌎 Chemometric analyses highlighted the sensitivity of the methods in detecting structural variations in monoclonal antibodies. 🌍The study emphasized the importance of advanced analytical techniques in monitoring and ensuring the quality of biopharmaceuticals. ----------- 🔗 Full study link: https://lnkd.in/eKuBCSRq #biopharma #monoclonalantibodies #NMRspectroscopy #chemometricanalysis #qualityattributes #advancedanalyticaltechniques #SnippetPhriday ------ 𝘋𝘰 𝘺𝘰𝘶 𝘭𝘪𝘬𝘦 𝘰𝘶𝘳 𝘚𝘯𝘪𝘱𝘱𝘦𝘵 𝘗𝘩𝘳𝘪𝘥𝘢𝘺 𝘴𝘦𝘴𝘴𝘪𝘰𝘯𝘴? 𝘙𝘦𝘤𝘰𝘮𝘮𝘦𝘯𝘥, ♻️ 𝘙𝘦𝘱𝘰𝘴𝘵, 𝘪𝘧 𝘺𝘰𝘶 𝘧𝘪𝘯𝘥 𝘪𝘵 𝘶𝘴𝘦𝘧𝘶𝘭. 𝗧𝗲𝗰𝗵𝗻𝗼𝗣𝗵𝗮𝗿𝗺𝗮𝗦𝗽𝗵𝗲𝗿𝗲 𝗟𝗟𝗖. 𝗕𝗶𝗼𝗽𝗵𝗮𝗿𝗺 𝗖𝗼𝗻𝘀𝘂𝗹𝘁𝗮𝗻𝘁 𝗮𝗻𝗱 𝗖𝗥𝗢 𝗵𝘁𝘁𝗽𝘀://𝗹𝗻𝗸𝗱.𝗶𝗻/𝗱_𝗾𝟲𝗣𝗨𝗙 𝗵𝘁𝘁𝗽𝘀://𝗹𝗻𝗸𝗱.𝗶𝗻/𝗴𝘆𝟮𝘇𝗺𝗦𝟱𝗺 ⏩ 𝘗.𝘚. 𝘚𝘵𝘢𝘺 𝘵𝘶𝘯𝘦𝘥 𝘧𝘰𝘳 𝘵𝘩𝘦 𝘥𝘦𝘵𝘢𝘪𝘭𝘦𝘥 𝘪𝘯𝘴𝘪𝘨𝘩𝘵𝘴 𝘢𝘣𝘰𝘶𝘵 mAbs 𝘢𝘯𝘥 𝘳𝘦𝘭𝘢𝘵𝘦𝘥 𝘤𝘰𝘯𝘵𝘦𝘯𝘵!

🌟 Discover EirGenix’s Educational Blog Series! 🌟 Have you explored our latest blog series yet (https://lnkd.in/gngj63j2) ? Dive into insightful articles on topics like optimizing Cell Line Development (CLD), the latest trends in Antibody Drug Conjugates (ADCs), key considerations for developing bispecific mAbs, and mastering both upstream and downstream mAb development. Plus, learn about the crucial aspects of Biologic Technology Transfer and much more! Join our community of biological developers dedicated to continuous learning. If you find our content valuable, please share it and help us in our mission to provide effective, affordable care to patients. Check it out here: EirGenix Blog Series 🚀 #Biotech #Pharma #Healthcare #LearningCommunity #EirGenix

🌟 Discover EirGenix’s Educational Blog Series! 🌟 Have you explored our latest blog series yet? Dive into insightful articles on topics like optimizing Cell Line Development (CLD), the latest trends in Antibody Drug Conjugates (ADCs), key considerations for developing bispecific mAbs, and mastering both upstream and downstream mAb development. Plus, learn about the crucial aspects of Biologic Technology Transfer and much more! Join our community of biological developers dedicated to continuous learning. If you find our content valuable, please share it and help us in our mission to provide effective, affordable care to patients. Check it out here: EirGenix Blog Series 🚀 #Biotech #Pharma #Healthcare #LearningCommunity #EirGenix #CDMO #CLD #mAb #ADC #CMO

At the recent 2024 Vaccine and Health Conference, Dr. Zhu Tao, Chief Science Officer at CanSino Biologics Inc.康希诺生物, presented about the latest clinical progress of CanSino's global innovative recombinant Pneumococcal Protein Vaccine (also known as PBPV). Dr. Zhu highlighted that PBPV possesses unique advantages such as high coverage, no restrictions by serotypes, and ease of production. Encouraging preliminary results have been obtained in the ongoing Phase I clinical trial for this vaccine. Dr. Zhu also engaged in insightful discussions about innovative vaccine platform technology reserves and multi-component and multi-valent vaccine development directions with fellow scholars and peers present at the conference. #QMportfolio #QMhealthcare #vaccinedevelopment #CanSinoBio #PBPV #VaccineResearch #Innovation #Healthcare #PneumococcalVaccine

Although pneumococcal infections are mild in most cases, it could be deadly or result in long-term problems. Compared to traditional type of vaccines, CanSino Biologics Inc.康希诺生物's PBPV offers the potential for broader serotype coverage. #Qiming #Healthcare #CanSino #2024VaccineAndHealthConference #Pneumococcal #PBPV #ClinicalTrial #Vaccine