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A new paper in Lab Animal from Dr Ben Davies describes a method to reduce and refine the use of mice when producing genetically modified mouse models, using sterile hybrid male mice generated by breeding two wild-type mouse strains: https://lnkd.in/dNFUsHZJ   Before modified embryos can be implanted, recipient mice must be mated with sterile males to create a pseudopregnancy for embryo transplant. Male mice either undergo surgical vasectomy under anaesthesia or require extensive breeding programmes to generate sterility.    In collaboration with the Mary Lyon Centre at MRC Harwell and The University of Manchester Faculty of Biology, Medicine and Health, funded by an NC3Rs skills and knowledge transfer award, Ben shows using sterile males, bred from C57BL/6J and Mus spretus strains, to prepare pseudopregnancy transfer recipients results in a similar pregnancy rate, birth rate and litter size compared to traditional methods.    Learn more about the project on our website: https://lnkd.in/dBsxxU3W

Is the #AnimalModel Market Set to Surge with Increased Usage in #Virology and #InfectiousDiseases? The booming #animalmodel market is poised for substantial growth, fueled by the escalating demand in virology and #infectiousdiseases research, the striking physiological parallels between humans and animals for effective drug testing, and a rising embrace of #CRISPR technology. These factors collectively underscore the pivotal role of animal models in advancing scientific understanding and #therapeutic development, driving a significant expansion in market size. Key Market Players: Taconic Biosciences, Ozgene, genOway , Hera BioLabs, The Jackson Laboratory., JANVIER LABS, Inotiv, Charles River Laboratories, Crown Bioscience., Trans Genic Inc. Explore the market overview: https://lnkd.in/dM3rVZ-H #AMR #AnimalModelMarket #VirologyResearch #InfectiousDiseases #DrugTesting #CRISPRTechnology #ScientificAdvancements #TherapeuticDevelopment #PhysiologicalSimilarity #MarketGrowth #BiomedicalResearch

Our latest guest article highlights key culturing techniques and best practices for producing uniform iPSCs. It includes discussion about monitoring genetic stability and identifying genetic instability through rigorous quality control, using animal origin free (AOF) defined media to create consistency, and proper cryopreservation of iPSCs, which has a profound effect on iPSCs future viability post thaw. Don’t miss it! #iPSCs #iPSC culture https://lnkd.in/edgb6cxx

#customerpublicationweekly Air #pollution has been shown to be harmful to the #reproductive system. A recent publication in Cell Discovery shows that, strikingly, the paternal exposure to PM2.5 could lead to hypogonadism in the male offspring. Specific small RNAs seem to play a critical role in this trans-generational effect. #singlecell #RNAseq with Singleron's #GEXSCOPE product identified genes whose expression patterns are altered in Leydig and Sertoli cells in the testis of the male offspring. https://lnkd.in/dYYRB_rv

The purpose of this systematic review in #SpinalCord was to determine the therapeutic efficacy of in vivo reprogramming of astrocytes into neuronal-like cells in animal models of #SpinalCordInjury. See ➡️ https://lnkd.in/eBFjfNy9

Discover the groundbreaking role of the HPS5 gene in equine genetics with experts Aiden McFadden, Katie Martin, and Dr. Robin Everts 🐴🧬 Learn how this gene influences white markings in horses and explore its implications for phenotypes. Dive into depigmentation in horses, discussing the role of EDX Whites and its connection to melanogenesis across species. 🎧 Click here to listen now: https://lnkd.in/gawYNxzp  #etalondx #equinegenetics #horsepodcast #horsescience #horsegenetics

🦈 In the wild, the Greenland shark can live to an impressive age of up to 392 ± 120 years, making it the longest-lived vertebrate. One might conclude that studying the Greenland shark would be the best approach to understanding ageing. However, this is only partially true. 🐁 Despite its impressive lifespan, the Greenland shark is not a good model animal for studying ageing. Several factors make the humble field mouse a much more practical research tool. Aside from the very much obvious considerations related to housing and feeding, studying ageing in a short-lived organism provides relatively rapid access to data. At the Biotest Facility, we are equipped and qualified to conduct research in biogerontology using mouse models. 📧 If you plan to undertake studies of drug efficacy, pharmacodynamics, pharmacokinetics, or biomarkers in aged mice, contact us at info@biotestfacility.com for further information and support. #Aging #AnimalResearch #Preclinical #DrugDevelopment #LifeScience

The journey of drug development is exploratory and variable. Target identification and validation stages encompass a multitude of experiments and approaches to ensure confidence in the target’s biological and therapeutic potential. In our most recent blog post, we provide a brief overview of how histopathology can be used as a quick and relatively efficient way to obtain initial data during the target identification and validation phase. Continue reading on our website: https://lnkd.in/gCmaxTc5 #Histopathology #VeterinaryPathology #CRO #TargetIdentification #TargetValidation #DigitalPathology #DigitalHistopathology

Animal Models and Their Alternatives Share the Preclinical Habitat To meet the demands of researchers and regulators, in vivo models are becoming more fit, while in vitro models, such as organ-chips, are exploring new niches. In this article GEN speaks with The Jackson Laboratory, Charles River Laboratories, Taconic Biosciences, Emulate, Inc., CN Bio and MIMETAS.