The management of autoimmune diseases has improved significantly since the beginning of the 21st century. However, treatment is still typically considered to be life-long and aimed at suppressing the symptoms. In this article published in NEJM, Müller et al. present a study of 15 patients with systemic lupus erythematosus (SLE) who were treated with a single infusion of CD19-targeted chimeric antigen receptor (CAR) T cells as B cell depletion is a potential strategy for achieving long-term drug-free remission. Patients received a single CAR T-cell infusion following fludarabine and cyclophosphamide preconditioning. Remarkably, all participants showed significant improvement according to disease-specific remission criteria, and immunosuppressive therapies were entirely discontinued. Although most experienced mild cytokine release syndrome, the therapy demonstrated a promising safety and efficacy profile, suggesting a new avenue for sustained remission in autoimmune diseases. https://lnkd.in/enuSFUpP #immunotherapy #autoimmunedisease #cartcelltherapy
Zhou Zhong, Ph.D.’s Post
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News in advancements in IBD Care! A recent study emphasizes the importance of testing for fecal Calprotectin to identify levels of gut inflammation levels and predict long-term disease outcomes. Calpro Products Highlighted: This study relied on the Calpro Easy Extract and CalproLab ELISA to extract and analyze stool samples for fecal calprotectin (fCal). This accurate assessment aids in understanding inflammatory activity within the gut. This study highlights the potential of fCal and fecal myeloperoxidase (fMPO) as complementary tools for assessing disease during regular clinical care. By utilizing a combination of fecal biomarkers (e.g. fCal), CRP, and clinical disease activity, it is possible to identify individuals who are at risk of developing IBD complications. Read the full article https://hubs.ly/Q02pXT5S0 #IBD #MedicalResearch #PatientCare #CalproELISA #answersinlifescience #Crohns #Ulcerativecolitis
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Clinical Pharmacist and Medical Writer at Innovations Medication Management, Inc.
Nipocalimab shows promising results in late-stage and mid-stage studies of generalized myasthenia gravis (gMG) and Sjögren's disease respectively. It blocks the FcRn receptor and reduces overall IgG. #autoimmunediseases #johnsonandjohnson #myastheniagravis #sjögrens #nipocalimab #pipeline https://lnkd.in/dyXfR5nz
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Such an important topic and a must read…
Did you know that March is #AutoimmuneAwarenessMonth? What are autoimmune diseases? - #AutoimmuneDiseases occur when the body's immune system attacks healthy cells, tissues and organs. While some are common, like multiple sclerosis, many are rare. In November last year, we published our Rare and chronic autoimmune diseases special edition, sponsored by Horizon Therapeutics. In its pages, we heard from people who suffered from symptoms for decades before getting the answers they desperately needed. Read the edition for FREE at https://bit.ly/40p5wQy
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Autoantibodies to peptidylarginine deiminase 4 (#PAD4) have been associated with #erosive disease in established #rheumatoid #arthritis (#RA). A recent study compared the clinical and prognostic value of anti-PAD4 antibodies in patients with early and established RA. Results revealed that baseline anti-PAD4 antibodies are differentially associated with joint damage in early versus established RA, with an association with severe joint disease only apparent in those with established RA. Anti-PAD4 antibodies were modestly associated with lower #DAS28-CRP levels posttreatment in the early RA population; however, other disease metrics did not differ by anti-PAD4 antibody status. 🔗https://lnkd.in/dFGbZdMz
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Early disease detection through lipidomics and polygenic scores --- We are excited to announce our latest co-authored publication, which explores the relationship between polygenic scores (PGSs) and lipid dysfunctions. Over 7000 individuals had their clinical lipid profiles and advanced lipidomics (179 lipid species) profiles analyzed. Nearly 700 significant associations between PGSs for 26 complex traits and 142 lipids were discovered. These associations offer insights into early lipid changes for diseases like type 2 diabetes, BMI, and venous thromboembolism. This study shows how PGSs can help detect lipid alterations in complex traits long before symptoms develop, helping us better understand disease mechanisms and design early prevention strategies. Read the full publication here: https://lnkd.in/eQYfkg9H #Genomics #Lipidomics #PrecisionMedicine #EarlyDiseaseDetection #lipotype #research #lipid #lipidomics #LipidMetabolism #lipidome
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Life Science Reagent Company | Biopharmaceuticals Company | ELISA Kits Manufacturer | Antibody Company | Recombinant Protein Supplier | Proteomics Company | Scientific and Medical Supplies
【Cited FineTest ELISA Kit】Cytokine ELISA Kit | Annals of the Rheumatic Diseases | IF: 27.4 Abstract: FineTest TNF-α ELISA Kit is cited by an article entitled "Single-cell transcriptome analyses reveal disturbed decidual homoeostasis in obstetric antiphospholipid syndrome" Published in Annals of the Rheumatic Diseases. (Read Full Text: https://bit.ly/4caJcQ9) Keywords: #Obstetrics, #AutoimmuneDisease, #Autoimmunity, #Inflammation, #ImmuneHealth
[Cited FineTest ELISA Kit] Current Research on Autoimmune Disease - FineTest ELISA Kit | FineTest Antibody | Wuhan Fine Biotech Co., Ltd.
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Understanding Neuromyelitis Optica Spectrum Disorder & Myelin Oligodendrocyte Glycoprotein Associated Disease - Accurate differential diagnosis from MS is crucial since both NMOSD and MOGAD require different treatment approaches - learn how Wieslab can help. https://hubs.ly/Q02Jbp_00
Understanding Neuromyelitis Optica Spectrum Disorder & Myelin Oligodendrocyte Glycoprotein Associated Disease
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Recent studies reveal a breakthrough in managing Epstein-Barr virus (EBV) infections, which are linked to various diseases, including several types of cancers. By targeting a specific metabolic pathway in infected cells, researchers have discovered a method to reduce latent EBV infections, potentially decreasing the risk of related malignancies. It is an innovative approach to developing therapeutic interventions and implementing preventive strategies in EBV-associated diseases. Learn more: https://bit.ly/4bYsxyG #MDForLives #CancerPrevention #MedicalInnovation #HealthScience #EBV #CancerResearch #TherapeuticInterventions #MedicalAdvancements #Virology #PaidSurveys #HealthcareSurveys
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Autoimmune diseases occur when the body's immune system mistakenly attacks healthy cells, tissues, or organs. This can lead to inflammation, pain, and a wide range of symptoms depending on the area affected. Traditional treatments have included immunosuppressive drugs, which can have broad effects on the immune system, potentially leading to side effects and increased vulnerability to infections. Monoclonal antibodies offer a more targeted approach by specifically binding to and neutralizing the molecules involved in the autoimmune response. #AutoimmuneDiseases #MonoclonalAntibodies #VETmAbBIO
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Severe immune #thrombocytopenia (ITP) caused by connective tissue diseases (CTD) may cause systemic bleeding and can even be life-threatening. There are many treatments for this disorder, but some patients do not respond. #Eltrombopag (a thrombopoietin receptor agonist) stimulates bone marrow to produce more platelets has been widely used in primary ITP, but there are few studies on CTD-ITP. A retrospective series of 20 CTD-ITP patients treated with eltrombopag after no response to first and second treatment options showed 70% complete response (ie 70% of patients had no detectable disease), and the drug was well tolerated. No undesired side effects were observed. This study provides more evidence for the use of eltrombopag to treat CTD-ITP that has not previously responded to treatment. 🔗https://lnkd.in/d_XFPKUk
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