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🔬 Excited to share some insights into the key biomarkers used in the diagnosis and monitoring of Inflammatory Bowel Disease (IBD)! 🔬 IBD, encompassing Crohn's disease and ulcerative colitis, is a chronic condition characterized by inflammation of the digestive tract. Here, we present a comprehensive list of essential biomarkers for IBD! These biomarkers are vital for understanding, diagnosing, and managing this complex disease, aiding in better patient outcomes and personalized treatment strategies. #IBD #Biomarkers #CrohnsDisease #UlcerativeColitis #MedicalResearch #Inflammation #PrimaNexus

Early disease detection through lipidomics and polygenic scores --- We are excited to announce our latest co-authored publication, which explores the relationship between polygenic scores (PGSs) and lipid dysfunctions. Over 7000 individuals had their clinical lipid profiles and advanced lipidomics (179 lipid species) profiles analyzed. Nearly 700 significant associations between PGSs for 26 complex traits and 142 lipids were discovered. These associations offer insights into early lipid changes for diseases like type 2 diabetes, BMI, and venous thromboembolism. This study shows how PGSs can help detect lipid alterations in complex traits long before symptoms develop, helping us better understand disease mechanisms and design early prevention strategies. Read the full publication here: https://lnkd.in/eQYfkg9H #Genomics #Lipidomics #PrecisionMedicine #EarlyDiseaseDetection #lipotype #research #lipid #lipidomics #LipidMetabolism #lipidome

The American Gastroenterological Association (AGA) recently endorsed the use of biomarker monitoring in the management of Crohn’s Disease. Learn about the suggested biomarker monitoring schedules in our infographic: bit.ly/434D7AJ #AGA #AGAGuidelines #Biomarkers #CrohnsDisease #CrohnsResearch #CrohnsAwareness #CrohnsManagement #CD #CDResearch #CDAwareness #CDManagement

Yet another study adding to our COPD experience spanning over 10 years! These findings provide context for upcoming results from FOOTPRINTS®, which aims to establish correlations between biomarkers and disease progression in a representative COPD population. FOOTPRINTS® is a prospective, longitudinal, 3-year study in ex-smokers with mild-to-severe COPD. It focuses on assessing the association between biomarkers of inflammation/lung tissue destruction and chronic obstructive pulmonary disease (COPD) severity and progression. The study presents baseline characteristics and select biomarkers of study subjects: https://lnkd.in/eX9XKD_D

Navigate scenarios with Crohn’s Disease (CD) – from symptomatic remission to postoperative care, ALPCO’s Biomarker Monitoring for the Management of CD infographic will serve as a helpful guide.    Download today for a fresh perspective on CD management: bit.ly/3UXO70M #AGA #AGAGuidelines #Biomarkers #CrohnsDisease #CrohnsResearch #CrohnsAwareness #CrohnsManagement #CD #CDResearch #CDAwareness #CDManagement

#WorldThyroidDay According to data from the WHO, thyroid disease affects over 300 million people worldwide and has become one of the most common diseases in the endocrine system. Although thyroid diseases are not as leading causes of death globally as cancer, their impact on quality of life cannot be ignored, often leading to misdiagnosis or delayed treatment due to hidden symptoms. Early detection and intervention can not only simplify the treatment process, but also greatly reduce the physical and mental burden and economic pressure on patients. C-Luminary Biotech can provide comprehensive thyroid function biomarker detection items to assist in early clinical diagnosis and treatment. #IVD #immunodiagnosis #chemiluminescence #assay #diagnostics #CLIA #hospital #biotech #cluminary #sharay1600 #sharetrybio

The management of autoimmune diseases has improved significantly since the beginning of the 21st century. However, treatment is still typically considered to be life-long and aimed at suppressing the symptoms. In this article published in NEJM, Müller et al. present a study of 15 patients with systemic lupus erythematosus (SLE) who were treated with a single infusion of CD19-targeted chimeric antigen receptor (CAR) T cells as B cell depletion is a potential strategy for achieving long-term drug-free remission. Patients received a single CAR T-cell infusion following fludarabine and cyclophosphamide preconditioning. Remarkably, all participants showed significant improvement according to disease-specific remission criteria, and immunosuppressive therapies were entirely discontinued. Although most experienced mild cytokine release syndrome, the therapy demonstrated a promising safety and efficacy profile, suggesting a new avenue for sustained remission in autoimmune diseases. https://lnkd.in/enuSFUpP #immunotherapy #autoimmunedisease #cartcelltherapy

Can expression of the PD-1 protein help differentiate inflammatory bowel disease (IBD) from other inflammation-related diseases, which is often challenging? The science on it remains inconclusive, but a new study describes results supporting the role of PD-1 expression as an indicator. Read the paper: PD-1-positive cells contribute to the diagnosis of inflammatory bowel disease and can aid in predicting response to vedolizumab Min Kyu Kim, et al. https://lnkd.in/etPicUkd #InflammatoryBowelDisease #InflammatoryDiseases #Inflammation #OpenAccess #Publication

🤗 📝 We are happy to share this article from a group of French autoinflammatory experts, including representatives of the Tenon Hospital (RITA member since 2022). It describes the first dominant somatic mutation of MEFV p.Thr577Ala, responsible for a pyrin-associated autoinflammatory disease. Have a read! ⬇

🤗 📝 We are happy to share this article from a group of French autoinflammatory experts, including representatives of the Tenon Hospital (RITA member since 2022). It describes the first dominant somatic mutation of MEFV p.Thr577Ala, responsible for a pyrin-associated autoinflammatory disease. Have a read! ⬇ https://lnkd.in/dedcMnND