MIA update – next week (Wednesday, February 26), we’re excited to welcome Robert Patro and Noor Pratap Singh, both from the University of Maryland’s Department of Computer Science and Center for Bioinformatics and Computational Biology. 📅 Wednesday, February 26 📍Acadia (75 Ames St, M1) and virtually 💬 Rob Patro 💡 Primer, 9 am: Counting is not easy: Assessing and quantifying uncertainty in abundance inferences from high-throughput sequencing data 💬 Noor Pratap Singh 💡 Seminar, 10 am: Uncertainty-aware analysis of RNA-Seq data using a tree-based framework 🧑🏫 Abstracts: broad.io/MIA 💌 Mailing list: bit.ly/MIACast 📺 Previous talks: broad.io/MIAPlaylist 🗓️ Calendar of events: broad.io/ewsc-calendar Both talks will be in person at the Broad (Acadia, M1) and broadcast over Zoom. If you do not have a Broad badge, please arrive at the 75 Ames St. entrance 10 minutes early with an ID to check in with security. We will escort folks up at 8:55 and 9:55 am; please email mia-team@broadinstitute.org if you arrive outside of these times. Broad Institute of MIT and Harvard, Department of Computer Science, UMD #SchmidtCenter #ModelsInferenceAlgorithms #MIA #RobPatro #NoorPratapSingh
Eric and Wendy Schmidt Center
Research Services
Cambridge , MA 1,980 followers
Converging machine learning and biology to illuminate the programs of life
About us
The Eric and Wendy Schmidt Center was born from the idea that interdisciplinary research between the data and the life sciences stands to transform biology and improve human health. Two recent revolutions inspired the creation of the Eric and Wendy Schmidt Center: the exponential growth and widespread adoption of data technologies like machine learning and cloud computing, and the dramatic advances in generating massive amounts of data about living systems through next-generation sequencing, single-cell genomics, and advanced medical imaging. Until now, these fields have largely developed in parallel. The Eric and Wendy Schmidt Center will foster a two-way street between the disciplines. We envision that biomedical problems will fuel foundational advances in machine learning — and that machine learning will drive what kinds of biological data scientists generate. We are deeply invested in ensuring that our commitment to the highest level of ethics and equity is brought to bear through each and every project. To that end, we work with researchers focused on engaging underrepresented groups, anticipating outcomes for vulnerable populations, and developing open-source tools that will maximize benefit to all. Join our mailing list at: bit.ly/ewsc-list
- Website
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www.ericandwendyschmidtcenter.org
External link for Eric and Wendy Schmidt Center
- Industry
- Research Services
- Company size
- 11-50 employees
- Headquarters
- Cambridge , MA
- Founded
- 2021
Updates
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In a new study published in Nature Communications, Eric and Wendy Schmidt Center’s Hannah Schlueter and Director Caroline Uhler introduce #PORCELAN, a statistical framework that automatically detects gene expression patterns linked to lineage progression. This method provides a systematic way to study how gene expression and cell state memory evolve through cell divisions, offering new insights into processes such as cancer progression. 🧬 Learn more: https://lnkd.in/egrvi5Ax Broad Institute of MIT and Harvard, MIT EECS, MIT Institute for Data, Systems, and Society (IDSS), MIT Laboratory for Information and Decision Systems (LIDS) #BroadInstitute #SchmidtCenter #MIT #MITEECS #MITIDSS #MITLIDS #CarolineUhler #HannahSchlueter #ScienceNews #ScienceResearch #SingleCellResearch #GeneExpression #ComputationalBiology
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Eric and Wendy Schmidt Center reposted this
Hannah Schlueter and Caroline Uhler developed a computational method, PORCELAN, that combines representation learning, tree-likeness scores, and a permutation strategy to compare lineage relationships between single cells with their relationships in another paired modality such as gene expression. They validated PORCELAN on simulated gene expression data paired with lineage information and applied it to recent datasets on lung cancer and embryogenesis in a mouse model and C. elegans. PORCELAN identified biologically meaningful patterns and genes, demonstrating its potential utility and versatility. Read more in Nature Communications. #BroadInstitute #Science #ScienceNews #Research #ScientificResearch
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🎉 Congratulations to Eric and Wendy Schmidt Center postdoctoral fellow Sebastiano Cultrera di Montesano and colleagues (first author Lara Ost, Herbert Edelsbrunner) on their recent paper, accepted to the Symposium on Computational Geometry! The authors examine the banana tree data structure, designed to maintain persistent homology, for dynamically changing time series data. Their study reveals that banana trees outperform traditional static algorithms, offering promising potential for real-world time series analysis: https://lnkd.in/ea2Yb4iv #BroadInstitute #SchmidtCenter #EWSC #SebastianoCultreradiMontesano #BananaTrees #ComputationalGeometry #ML #ScienceResearch #UniversityofVienna #ISTA Broad Institute of MIT and Harvard
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We look forward to welcoming Aleksandra Walczak (CNRS European Nuclear Society (ENS)) and Andrea Mazzolini (Laboratoire de Physique de l'Ecole normale supérieure (LPENS)) to our first Models, Inference & Algorithms (#MIA) meeting of 2025! This Wednesday, they will discuss the biological and computational perspectives on selection and optimization, and using machine learning to understand the dynamics of immune repertoires. View our spring schedule – all meetings occur on Wednesdays: 📅 February 12 💬 Aleksandra Walczak 🏫 CNRS European Nuclear Society (ENS) 💡 Primer, 9:00 am: Immune repertoires: specificity and dynamics 💬 Andrea Mazzolini 🏫 Laboratoire de Physique de l'École Normale Supérieure (LPENS) 💡 Seminar, 10:00 am: Extracting dynamical properties of the immune repertoire from noisy sequencing data 📅 February 26 💬 Robert Patro 🏫 University of Maryland 💡 Computational biology and bioinformatics 📅 March 5 💬 Flash talks 📅 March 12 💬 Ellen Zhong 🏫 Princeton University 💡 Geometric DL for cryoEM 📅 March 19 💬 Andrew White 🏫 FutureHouse, University of Rochester 💡 LLM for chemistry 📅 April 2 💬 Gökçen Eraslan, Surag Nair 🏫 ReLU, BRAID, Genentech 💡 Nona, a novel multimodal masked modeling framework for functional genomics 📅 April 9 💬 Harri Lähdesmäki, Alexandru Dumitrescu, Dani Korpela 🏫 Aalto University 💡 TBD 📅 May 14 💬 Ophelia Venturelli 🏫 Duke University 💡 TBD 📅 May 28 💬 Faisal Mahmood 🏫 Harvard Division of Medical Sciences 💡 TBD **Learn more and stay tuned for a complete list of spring 2025 talks, titles, and abstracts at broad.io/MIA. The MIA Initiative, a weekly pedagogical meeting series, brings together biologists and machine learning researchers on Wednesdays in Acadia (75 Ames St, M1) and virtually. It features a primer with breakfast at 9:00 am, followed by a meeting at 10:00 am, and a discussion at 10:50 am. If you do not have a Broad badge, please arrive at the 75 Ames St. entrance 10 minutes early with an ID to check in with security. We will escort folks up at 8:55 am and 9:55 am; please email mia-team@broadinstitute.org if you arrive outside of these times. Broad Institute of MIT and Harvard #SchmidtCenter #EWSC #ModelsInferenceAlgorithms
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🎉 Congratulations to Eric and Wendy Schmidt Center postdoctoral fellow Uthsav Chitra and colleagues (Daisy Dan, Fenna Krienen, Ben Raphael) on their latest preprint! Their work introduces GASTON-Mix, an unsupervised deep learning approach that leverages biological constraints to infer spatial domains and spatial gradients of gene expression more accurately than existing methods. Learn more: https://lnkd.in/gPgxpAkB #BroadInstitute #SchmidtCenter #EWSC #Princeton #UthsavChitra #GeneExpression #SpatialDomains #SpatialGradients #UnsupervisedDeepLearning #ComputationalBiology #MLinBio #ScienceResearch Broad Institute of MIT and Harvard
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Despite the snow, we have a full house for our first colloquium of 2025, featuring Barbara Engelhardt! You can join now online via YouTube livestream: broad.io/ewsc If you missed the talk, stay tuned for a recording that will be posted on our site. Broad Institute of MIT and Harvard #BroadInstitute #SchmidtCenter #ewsc #BarbaraEngelhardt #MLinBio
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❄️🗞️ An inaugural symposium, exciting new research, and well-deserved awards – our winter newsletter has snow much to share! On this chilly Wednesday, catch up on the latest from the Eric and Wendy Schmidt Center at the Brr-oad Institute. https://lnkd.in/eeeuQsMJ Broad Institute of MIT and Harvard #SchmidtCenter #EWSC #BroadInstitute #ML #AI #ComputationalBiology #CausalInference #RepresentationLearning #ActiveLearning #BiomedicalAI #MachineLearning #WinterNewsletter #ScienceAtScale
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This Thursday, February 6 – join us at the Broad Institute of MIT and Harvard (or virtually) from 4:00 - 5:00 pm (refreshments at 3:30 pm) for Barbara Engelhardt's colloquium. Learn more and register: https://lnkd.in/eZH_h8CV #SchmidtCenter #BroadInstitute #MITEECS #BarbaraEngelhardt #GladstoneInstitutes #StanfordDBDS Gladstone Institutes Stanford University
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‼️ Call for abstracts – due January 31 (tomorrow). Join the Eric and Wendy Schmidt Center Symposium: Biomedical Science and AI on April 30 and May 1, 2025, which will bring together experts in the field who develop the foundations of machine learning, and apply the resulting methods to understand the programs of life and how they connect across scales – from proteins to cells to tissues and organisms. We invite researchers, particularly those in the early stages of their independent careers (less than five years in an independent position), postdoctoral researchers, and PhD students to submit an abstract. Among the submissions, we will select eight abstracts for short talks and 40 abstracts for posters. 📑 Abstract submissions are due tomorrow -- January 31. Learn more and see our current speaker lineup: https://lnkd.in/eVcrPgf7 Stay tuned for more details about the symposium!
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