MOSAIC research

🎉 We’re excited to announce we have now exceeded 1,000 patients with our partnering cancer research hospitals across Europe and the US. Unlike similar studies, MOSAIC is both broad and deep, covering 7 cancer indications and 6 data modalities, including clinical and longitudinal data. By using 10x Genomics single-cell and spatial technologies on whole tissue sections, MOSAIC fully captures TME heterogeneity. We believe that the synergy of large scale #spatialomics data and #AI will help us decode cancer complexity. Follow the MOSAIC journey here: https://lnkd.in/evNvWbhy Gustave Roussy, CHUV | Lausanne university hospital, Universitätsklinikum Erlangen, Charité - Universitätsmedizin Berlin, University of Pittsburgh

As we head into MOSAIC’s second year, we reflect on the ground we've covered. From selecting the right partners and technologies to ensuring seamless coordination across multiple hospitals and disciplines, we’ve gained invaluable insights into managing large-scale, multidisciplinary research. 📕 In our latest blog we explore some of the challenges we encountered in setting up this large-scale multi-center initiative, and how we solved them. https://lnkd.in/gvYbWUUt Photo credit: 10x Genomics

In this new series, we’re getting to know some of the people behind MOSAIC. In the first edition, meet Rita Sarkis, Scientist and Data Generation project manager at CHUV. Rita’s role at the Institute of Pathology is to manage the data generation for MOSAIC. Her lab integrates the building blocks provided by oncologists, clinical data managers, and pathologists, specializing in particular in performing the Visium workflow. Follow the MOSAIC journey: https://lnkd.in/evNvWbhy #spatialomics #AI #cancerresearch

👀 Look inside the largest spatial omics dataset in oncology. With MOSAIC-Window, we’re making a 60-patient subsample from the larger MOSAIC dataset available to researchers, allowing them to work with novel data from cutting-edge modalities, such as single-cell and spatial omics, to test hypotheses. You can now explore a sample of spatial and multi-omics data from the MOSAIC project, via our demo: 🧬 Spatial gene expression 💻 Cluster analysis 🔬 Localization of cell types 📊 Differential expression analysis Try our demo here: https://lnkd.in/ecV3h47w #spatialomics #cancerresearch #AI

To mark MOSAIC’s 1,000 patient milestone, we spoke to the project partners at Gustave Roussy, CHUV | Lausanne university hospital, Universitätsklinikum Erlangen, Charité - Universitätsmedizin Berlin and University of Pittsburgh to discuss how we can continue breaking new ground in #spatialomics research. At Owkin, we are developing #AI systems to augment the resolution of spatial omics data, and to make biological discoveries from this data. Watch the video and follow the MOSAIC journey here: https://lnkd.in/evNvWbhy

📰 Check out MOSAIC in this month’s issue of Pharmaceutiques Magazine! Spatial omics technologies are poised to deliver major scientific breakthroughs in the next few years, connecting the different cell types that coexist in the tumor microenvironment and bringing a new understanding of cancer. We believe that the convergence of large-scale spatial omics data and AI will power the next revolution in cancer research. Read more: https://lnkd.in/eBP2h-e

Exciting progress yesterday at our Science Day for the MOSAIC project, held in collaboration with our consortium partner hospitals. The day included a productive MOSAIC joint steering committee meeting, where we covered key developments: 💊 Expanded therapy areas, including the addition of Head & Neck as the 8th area 📈 Reached a major milestone of 1,000 patients in data generation 🤖 Discussed the powerful synergy between AI and spatial omics 🔬 Explored new avenues for discovery and scientific publications Follow the MOSAIC journey at: https://lnkd.in/etSXzVKh Gustave Roussy, CHUV | Lausanne university hospital, Universitätsklinikum Erlangen, Charité - Universitätsmedizin Berlin, University of Pittsburgh

Following our 1,000 patients milestone, we’re excited to be opening a 60-patient subset from the larger MOSAIC dataset (7,000 patients) through MOSAIC-Window. Soon, researchers will be able to apply for access to this data via the European Genome-Phenome Archive (EGA), allowing them to: 📈 Look inside the largest spatial omics dataset in oncology 🧫 Work with cutting-edge modalities like spatial omics and single-cell data 🔬 Run spatial omics proof-of-concept studies before moving to larger projects Find out more: https://lnkd.in/e_awrTTK You can also visit us at ESMO booth #511 on 13-17 September as we present MOSAIC-Window to the scientific community. #spatialomics #AI #openscience

Earlier this month, we attended the International Spatial Biology Congress 2024, where the significance of spatial biology in drug discovery and development was a key focus. In our latest blog, we provide an overview of the discussions, highlighting the opportunities that spatial biology offers in modern drug discovery and development, as well as addressing the challenges and future directions for the field. 📕 Read the blog at https://lnkd.in/eRkcxD4R #spatialomics #drugdiscovery

Mark your calendars 🗓️ On June 17 at 16:20 CEST, our Principal Research Scientist, Atanas Kamburov, will present on MOSAIC alongside Dr. Stefan Florian from Charité - Universitätsmedizin Berlin at the Current Topics in Bioinformatics Symposium in Berlin. Dr. Florian will introduce the academic-industry collaboration, while Atanas will discuss some of the exciting initial results generated by the Owkin team from MOSAIC. Register now https://lnkd.in/eCJiVHBC