NCI Center for Cancer Research

🎉 Last week, we celebrated the incredible career of Steven A. Rosenberg, M.D., Ph.D., Chief of the Surgery Branch. Hundreds of attendees both in-person and online came together to honor his pioneering in the development of effective immunotherapies for patients with advanced cancer. Former and current colleagues, trainees and patients were able to thank Dr. Rosenberg for his impact on the field and discuss the optimism they have for the future of cancer research because of his work.    Thank you to the Center for Excellence in Immunology for sponsoring, the organizers and to everyone who participated in this incredible symposium. 👏 Share your favorite photo if you attended or a memory you have with Dr. Rosenberg in the comments! National Cancer Institute (NCI), NIH Clinical Center (CC), The National Institutes of Health

🗞 IN THE NEWS: Sen. Jack Reed (D-RI) visited NIH in September and stopped by the labs of Christine M. Heske, M.D., and Brigitte C. Widemann, M.D., from our Pediatric Oncology Branch. Read more in this article in the NIH Record. ➡ https://go.nih.gov/nRqTJKW ⭐ In the first photo, Dr. Heske shows Reed a well plate containing rows of treated and untreated cells for comparison. ⭐ In the second photo, Monica Bertagnolli, M.D., NIH Director, chats with Reed and Dr. Widemann while walking through the Clinical Center's Pediatric Oncology wing. National Cancer Institute (NCI), The National Institutes of Health, NIH Clinical Center (CC)

More renowned speakers are on the agenda for the #NCIConnect and #MyPART webinar, titled: AYA and Primary CNS Tumors: Unmet Needs and Opportunities for Collaboration. These speakers are addressing Care and Clinical Trial Access for adolescents and young adults (AYA) with primary central nervous system (CNS) tumors. Don't miss your opportunity to hear from Drs. Mark Gilbert, Nicole Drezner, Brigitte Widemann, and Marta Penas-Prado. REGISTER: https://go.nih.gov/nQcX4We. 📅 Wednesday, October 30, at 11 a.m. ET. Co-hosted by National Cancer Institute (NCI) and NCI Center for Cancer Research Cancer Moonshot programs, NCI-CONNECT and MyPART.

💡 NEW FINDINGS: Osteosarcoma is a rare, aggressive bone cancer that is most often found in children and young adults, but that also happens to be common in pet dogs. In a new study, researchers from CCR, including Amy LeBlanc, D.V.M., Baris Turkbey, M.D., Peter Choyke, M.D., and Stephanie Harmon, Ph.D., analyzed tumor data from 245 pet dogs with naturally occurring osteosarcoma and identified three distinct subtypes of tumor microenvironments, which could help predict survival outcomes.    The researchers also found these same three subtypes in human osteosarcoma, suggesting that these studies in dogs can be used to gain a better understanding of how the disease progresses in humans 🐶   ➡ Read more: https://lnkd.in/eu3hUuZQ   Image Description: Kaplan-Meier survival plots showing overall survival (A) and disease-free intervals (B) for 186 canines. The three tumor microenvironment subtypes strongly stratify both overall survival and disease-free intervals. National Cancer Institute (NCI), The National Institutes of Health, NIH Clinical Center (CC), National Institutes of Health (NIH): Intramural Research Program (IRP)

Interested in leveraging CRISPR-based technology to study genetic determinants of oxidative stress? Join us at National Institutes of Health (NIH): Intramural Research Program (IRP). We have a Postdoc position in my Group at NCI Center for Cancer Research. https://lnkd.in/eu4-sEFT

🗞 IN THE NEWS: Krishnan R. Patel, M.D., Assistant Research Physician in our Radiation Oncology Branch, was quoted in this MedPage Today article about a study aiming to personalize radiation therapy for bladder cancer patients. ➡ https://go.nih.gov/P9ae25R Krishnan Patel

If you care about cancer in adolescents and young adults (AYAs), then you should attend our upcoming free webinar—AYA and Primary CNS Tumors: Unmet Needs and Opportunities for Collaboration. The line-up of speakers is star-studded, starting with the NCI Center for Cancer Research Acting Co-director, Dr. James Gulley. 📅 Wednesday, October 30, at 11 a.m. ET. REGISTER: https://go.nih.gov/nQcX4We The National Cancer Institute (NCI) and NCI Center for Cancer Research Cancer Moonshot programs, NCI-CONNECT and MyPART, are co-hosting this webinar to engage and educate the public on the unmet needs, gaps in care, and opportunities for collaborative care and development of effective therapies for AYAs with primary central nervous system (CNS) tumors.

📹 WATCH: Steven A. Rosenberg, M.D., Ph.D., Chief of CCR’s Surgery Branch, was interviewed live by The Washington Post for their “Chasing Cancer” series. He answered questions about the past, present and future of immunotherapy, including his hopes for how this area of research will continue to shape cancer care. ➡ https://go.nih.gov/0sB9HGr (Skip to 27:54 for Dr. Rosenberg’s segment) NIH Clinical Center (CC), National Cancer Institute (NCI), The National Institutes of Health, National Institutes of Health (NIH): Intramural Research Program (IRP)

👏 Last week, the NCI Center of Excellence in Chromosome Biology (CECB) hosted a two-day event titled “Histone Modifications and Chromatin Structure Symposium.” Sessions explored the impact of histone modifications on gene regulation and development, chromatin remodeling, organization, DNA replication, repair, and the assembly of heterochromatin. ⭐ On the top left, Shiv Grewal, Ph.D., Chief of CCR’s Laboratory of Biochemistry and Molecular Biology and one of the event organizers, gave a talk titled “The Molecular Basis of Heterochromatin Assembly and Epigenetic Inheritance.” ⭐ On the top right, Joanna Wysocka, Ph.D., of Stanford University gave a talk titled “Human Development and Evolution Through the Gene Regulatory Lens.” ⭐ On the bottom, investigators discussed their work in a poster session. National Cancer Institute (NCI), The National Institutes of Health, National Institutes of Health (NIH): Intramural Research Program (IRP)

CCR researchers who investigate cancer health disparities have found that breast cancers from African American, European American and Kenyan patients have different tumor mutation patterns. Now, researchers are working to understand how ancestry, socioeconomic and environmental factors and other conditions contribute to these disparities. ➡ Read more: https://lnkd.in/exmB8XP3 Understanding molecular differences in cancer development may help clinicians develop new treatments to bridge health disparity gaps, illustrated by the suspension bridge in this image. National Cancer Institute (NCI), National Institutes of Health (NIH): Intramural Research Program (IRP)