Scripps Research Digital Trials Center

In 2020, we partnered with CareEvolution, Inc to launch the Scripps Research Digital Trials Center to support our mission to address the world’s most pressing health concerns. With our combined expertise, technical platform, partner network, and our community of participant partners, we have a goal to accelerate critical research across the globe, starting at home in the United States, with a focus on working with communities that have traditionally been underrepresented in biomedical research. To learn more, visit digitaltrials.scripps.edu https://lnkd.in/gNp8dQvJ

Our work on the feasibility of home-based testing for acute respiratory viruses - DETECT-AHEAD - is in The Lancet #DigitalHealth : https://lnkd.in/g9-diqkm In this direct-to-participant trial, we showed early feasibility of a decentralized program to prompt individuals to use an at-home test based on self-reported symptoms or changes in their wearable sensor data. We recruited 450 participants, 52% from populations historically under-represented in biomedical research. All participants shared their EHR, and 81% of the participants used the wearable device consistently throughout the study. 39% were prompted to self-test, and 52% of prompted successfully completed an at-home self-test. We identified several barriers to adequate participation that should be addressed before large-scale implementation, in particular around comprehension of study instruction provided digitally. The decentralized format of this trial lays the groundwork for future at-home testing studies, including participant-provided wearable data and self-reported symptoms, and for closing the loop by returning information back to the participant. Steve Steinhubl, Erin Coughlin, Felipe D., Matteo Gadaleta, Michael Hung, Janna Ter Meer, Jennifer Radin, Ed Ramos, Katie Baca-Motes, Jay Pandit at Scripps Research Digital Trials Center, and Dimitri Talantov

Emerging evidence suggests sleep disturbances may contribute to dementia development. To explore this link, the Scripps Research Digital Trials Center has launched the REFRESH-NOW study, led by Stuti Jaiswal, MD, PhD. This study will assess the impact of sleep duration and irregularity on cognitive outcomes in women aged 55+ using wearable activity trackers and the MyDataHelps app over three years. “Wearables have the potential to revolutionize sleep research," says Jaiswal. "Commercially available activity trackers collect data passively making it very simple for people to participate in sleep research from the comfort of their own home and to share real-world data with researchers over months or even years." Participants will share de-identified sleep data, complete surveys, and undergo cognitive assessments to help identify sleep-related risk factors for cognitive decline. Learn more at https://ow.ly/tuiI50SCE8g and join the study at https://ow.ly/WvfC50SCE8h.

Congratulations to Professor Eric Topol for being included in the 2024 #TIME100Health list. The TIME Magazine list recognizes the impact, innovation and achievement of the world’s most influential individuals in health. Topol is a leading physician-scientists and a pioneer of the field of individualized medicine—harnessing the power of digital and genomic technologies to render better healthcare for all of us. https://lnkd.in/g2ZNcKfY

Can wrist-worn devices, such as activity trackers, help long COVID patients reduce the severity of symptoms? Watch as the principal investigator of our Long COVID Wearable Study, Julia Moore Vogel, explains how a technique called pacing may help people manage their symptoms better. https://lnkd.in/gvC4zGQJ

The objective of the Virtual Advisory Team is to empower research participants to provide input on how research projects at the Scripps Research Digital Trials Center are conducted. Team members attend regular meetings and provide candid feedback on all aspects of projects to ensure that the research is accessible, relevant and meaningful to members of diverse communities and addresses their most pressing health questions. We currently welcome applications for the 2024-2025 Digital Trials Center Virtual Advisory Team. Share this with those you feel may be interested. Learn more and apply here: https://lnkd.in/gVNKtR5t

PowerMom FIRST stands for Fighting Inequity and Racism with Supportive Technology. PowerMom FIRST is a sub-study within the PowerMom Research Platform to understand whether there is a relationship between systemic racism and maternal health outcomes. To explore these outcomes, participants may be provided with a free Fitbit (now part of Google) Luxe wearable sensor & a Fitbit Scale. Sensors are used to monitor key health & behavioral metrics, like heart rate, weight, activity and sleep, over time. To learn more, visit: https://lnkd.in/gwG4yVKW

The City of San Diego declares today "Scripps Research Day" in honor of the institute's century of discoveries into life-saving medicines, as well as for its influential force in shaping the local bioscience community. Learn more about our 100 years of global scientific impact: https://100.scripps.edu/

Hungry to learn how your body responds to certain foods? The answer may lie in precision nutrition, a field that looks into the ways food impacts how we move, feel, and function. Check out this interactive learning resource from PROGRESS to learn more: progress.scripps.edu/about

Do we want to build sustainable and better health futures? How can the need for a private sphere in health and wellness, wearables and and mobile applications be balanced with the good that can be done for the individual and society through sharing health data (for the individual, good through sharing data with their their care providers, and for society through individuals voluntarily donating data for research? In very many areas of policy development, there is a debate, and the winner takes all. In our just published article in Nature Portfolio Journals: npj Digital Medicine we (Stephen Gilbert (Else Kröner Fresenius Center for Digital Health), Katie Baca-Motes (Scripps Research Digital Trials Center, CareEvolution), Giorgio Quer (Scripps Research), Marc Wiedermann (Robert Koch Institute) and Dirk Brockmann (Technische Universität Dresden) address this question, and ask: - how can a solution for the future be found, instead of a short lived policy dead end. - Citizens / patients need to have control over data collected in their private sphere. - We need solutions for the scalable and safe use of this data in research and public health, when we have citizen consent to do so. - Large scale COVID-19 data donations show us both paths are possible. - Our research shows a means for a scaleable and long-term solution (https://lnkd.in/eGdJPWAt) See the new paper here: "Citizen data sovereignty is key to wearables and wellness data reuse for the common good" https://lnkd.in/ep-YeFmf