ToxMinds BVBA

Excited to be attending #EUROTOX2024 congress! It’s been an incredibly informative and engaging event so far, with insightful discussions on the latest trends and scientific news. It’s always great to connect with like-minded professionals, exchange ideas, and explore opportunities for collaboration. Looking forward to more inspiring sessions and conversations throughout the event!   #Congress #Toxicology #NAMs #ToxMinds

Join us at the #Eurotox2024 congress in Copenhagen where our team, Thomas Petry, Francesca Tencalla, Sanghamitra Mishra, and Celine De Roy will share valuable insights during our poster presentations. Don’t miss this opportunity to engage with our experts.   We are looking forward to connecting and exchanging ideas with you. #EUROTOX2024 #NewApproachMethodology #NAMs #Congress #SafetyAssessment #Cosmetics #Regulatory #Impurities

We are pleased to announce that we will be exhibiting at the EUROTOX 2024 congress in Copenhagen, Denmark from September 8-11th. Join us at booth No.13 to discuss how we can assist with your product safety and regulatory requirements. We are excited to connect and explore opportunities together! #EUROTOX2024 #Toxicology #SafetyAssessment #Productsafety #Congress

📢 🎯 A recent study by Cheung et al. (2024) investigated the genotoxicity of nitrosamine impurities found in ACE inhibitors. The study confirms that the existing CPCA approach, which supports a limit of 1500 ng/day for these impurities, is appropriate. It further validated this limit through in vivo tests, including the liver comet assay and the Big Blue® mutation and duplex sequencing assays, all of which showed a lack of genotoxicity. These findings support using ICH Q3B limits for controlling N-nitroso ramipril and N-nitroso quinapril. The authors also suggest considering these results when evaluating appropriate AI and control strategies for structurally similar compounds. #nitrosamines #ACEinhibitors #enhancedAmestest #CPCA #BigBlue #Duplexsequencing #ICHQ3B https://lnkd.in/gRbkeyiH

📢 Considering the growing need for practical approaches to assess PFAS, a recent article by Patlewicz et al. from the US EPA's Office of Pollution Prevention and Toxics (OPPT) and Center for Computational Toxicology and Exposure (CCTE) demonstrates a pragmatic application of read-across techniques to categorise and group these chemicals. These categories are organized into broad classes, such as Perfluoroalkyl acids (PFAA) and their precursors, with subdivisions based on factors like chain length that influence toxicity and bioaccumulation. Overall, the grouping approach is aimed at identifying representative candidates for data collection, potential testing, development of QSAR models and hazard assessment. #PFAs #readacross #grouping #chemicalcategories #NAMs #PBT https://lnkd.in/g6EFjqv6

🚨 The European Chemicals Agency (ECHA) adopted and published a guide for enforcement of mixture-classifications based on the bridging principles in July 2024. The guide was published following a pilot project on the classification of mixtures including detergents and cleaning products, as part of the ECHA Enforcement Forum. Four topics have been described in the guide, such as the choice of the bridging method; the application of weight of evidence (WoE) using expert judgement; similarity of mixtures and classification method for tested reference mixtures. The basic rules related to the above-mentioned four areas were briefly described as follows:       a. Bridging method: only one bridging principle can be applied per hazard class evaluated for the untested mixture       b. WoE using expert judgement: This should only be used as a part of the hazard evaluation. Further, WoE used together with bridging principles applies only to that specific bridging principle.       c. Substantially similar mixtures: Usually two or more tested reference mixtures are used for applying the bridging principle ‘substantially similar mixtures’, in order to eventually cover all key ingredients with the same chemical properties and functionalities present in the untested mixture.       d. Tested reference mixtures: The pre-requisite for applying this bridging principle is that any test method used to classify the reference mixture must be suitable to conclude on classification in accordance with Article 6 of the CLP Regulation. Link: https://lnkd.in/dQCystrt #Chemicals #CLPRegulation #CLP #Hazard #MixtureClassification #Mixtures #Detergents #CleaningProducts

Wareing et al. (2024) recently published a most interesting article presenting their investigation on the applicability of 3 skin sensitisation NAMs (i.e., DPRA, LuSens, h-CLAT) to eight inorganic nanomaterials (NM) including TiO2 and SiO2. The NAMs were technically applicable to NM using a specific sample preparation, the NANOGENOTOX dispersion protocol and method modifications to reduce interaction of the NM with the photometric and flowcytometric read-outs. The results of the three assays were combined according to the defined approach described in the OECD Guideline No. 497. The investigators concluded that the skin sensitisation NAMs adopted by the OECD testing guidelines are currently not a good fit for testing inorganic nanomaterials. Access the full paper: https://lnkd.in/dqvydfiV   #Nanomaterials #SkinSensitisation #NAMs #Inorganic #InorganicNanomaterials #REACH #Cosmetics #DefinedApproach #OECDTG497 #TiO2 #Silica

🌟 Celebrating Unity and Team Spirit at ToxMinds India 🌟 Our Bangalore team came together to celebrate India's Independence Day, creating a vibrant and uplifting atmosphere in the office. It's always inspiring to see our team come together, showcasing the unity and dedication that make ToxMinds a great place to work. Here's to many more moments of shared success and collaboration! #OfficeCulture #TeamToxMinds #Bangalore #IndependenceDay

🌟 Welcome to Our New Additions to the ToxMinds Team! 🌟 We are excited to announce the joining of Mr. Nirav Limbasiya, M.S. (Pharm.), UKRT and Mr. Krishna Chaitanya, M.Pharm., DABT. Nirav has more than 15 years of industry experience in the human health hazard and risk assessment of chemicals and cosmetics. He spent 15 years working at Kenvue (previously Johnson & Johnson, consumer division), where he developed his expertise in ensuring product safety and regulatory compliance across the EMEA region. Krishna brings over 12 years of industry experience in toxicology and risk assessment, with a strong focus on cosmetics, OTC drugs, and medical devices. He has significant preclinical experience of more than 6 years which he acquired during his time at Aurigene and Vimta and spent 5 years at Kenvue, where he contributed to hazard assessments and regulatory submissions for numerous products. We’re thrilled to have them on board. Both will further strengthen our team, increasing our capacity to provide state-of-the-art product safety and regulatory compliance services. We are looking forward to a successful journey together!

🚨 📢 In a most interesting commentary, Mansouri et al. point out and discuss the importance of understanding the pivotal role of chemical similarity (structural and biological) in chemical grouping/clustering and classification approaches. The effectiveness of these approaches depends on the right definition and measure of similarity, which varies based on the context and objectives of the underlying studies. 👉 An important read especially for those being engaged in analogue and grouping-based hazard and classification discussions occurring, for example, under REACH and/or ECHA’s ‘Assessment of Regulatory Needs’ (ARN) approach to hazard classifications. Link: https://lnkd.in/dVdGT8J4 #Grouping #ReadAcross #Classification #NAM #NewApproachMethdoologies #ComputationalToxicology #QSAR #ChemicalSimilarity #BiologicalSimilarity #StructuralSimilarity #AssessmentRegulatoryNeeds #ARN #REACH