Katalyze AI reposted this
What is Inherent Biological Variability? 1. Majority of new medicine from oncology to diabetes drugs today are probably Large Molecule drugs. Your regular #Aspirin has 21 atoms compare to 20,000 atoms at #Humira produced by AbbVie [an anti-inflammatory biologic drug used to treat a variety of autoimmune and inflammatory conditions] 2. These large molecules are mostly produced by large/expensive biomanufacturing facilities and cannot be manufactured by regular chemical processes. 3. Any Biologics manufacturing uses living organisms to grow target molecules. This living organism could be microbial, mammalian or plant-based. 4. Those living organisms are imperfectly understood, as are the exact conditions they require for optimal growth. This means that variability is inherent to the biomanufacturing process. To solve this problem we need complex models, one would dare to say, Large Biological Models....