Nanolive SA

𝗖𝗵𝗼𝗼𝘀𝗲 𝗡𝗮𝗻𝗼𝗹𝗶𝘃𝗲 𝗳𝗼𝗿 𝗻𝗼𝗻-𝗶𝗻𝘃𝗮𝘀𝗶𝘃𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗮𝘁 𝗵𝗶𝗴𝗵 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 🔬 To find out how our imaging systems use holotomography to reveal cellular insights, visit our new technology page: 🔗 https://bit.ly/3yhik1v #labelfreeimaging #biotechnology #sciencecommunication #medtech #innovation #cellimaging #research #technology

📬 In our October newsletter, discover how scientists are using Nanolive’s label-free holotomography and machine learning solutions for in vitro toxicology and drug safety studies. Additionally, explore recent publications in the fields of neuroscience and oncology.  Each month we cover the latest applications of AI for live cell imaging analysis and highlight the latest publications powering drug discovery and cosmetics.    ⬇ Click to read October's news! #ToxicologyResearch #Microscopy #LabelFreeImaging #Nanolive 

𝗜𝗻𝗱𝘂𝘀𝘁𝗿𝘆 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 𝗮𝗹𝗲𝗿𝘁! 𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗖𝗮𝗿𝗱𝗶𝗼𝘁𝗼𝘅𝗶𝗰𝗶𝘁𝘆 𝗔𝘀𝘀𝗲𝘀𝘀𝗺𝗲𝗻𝘁 𝘄𝗶𝘁𝗵 𝗛𝗼𝗹𝗼𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝘆 Don’t forget to sign up for a one-off webinar on October 22nd. In this webinar, Ambroise Garry, the Group Head for Global Investigative Toxicology within preclinical safety at Sanofi will discuss holotomography data on the responses of human iPSC-derived cardiomyocytes to established drugs known primarily for inducing phospholipidosis, which may also trigger cell death. Cardiotoxicity is a significant cause of clinical trials failure in new drug candidates, contributing to the overall failure rate of around 90% for all drug candidates. Phenotypic screening provided by technologies such as high-content live cell imaging could provide an opportunity to catch failures at an earlier, in vitro stage, and increase the translatability of drugs to clinic. 𝗧𝗼𝗽𝗶𝗰𝘀 𝗰𝗼𝘃𝗲𝗿𝗲𝗱: ·      Cardiovascular derisking with label-free live cell imaging ·      Drug-induced phospholipidosis ·      Label-free quantification of lipid droplets, lamellar bodies, and cytotoxicity evaluation in cells ·      IC50 calculation from live cell imaging ·      Doxorubicin-induced cardiotoxicity 𝗧𝗵𝗶𝘀 𝗲𝘃𝗲𝗻𝘁 𝘄𝗶𝗹𝗹 𝗼𝗻𝗹𝘆 𝗯𝗲 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲 𝗼𝗻𝗹𝗶𝗻𝗲 𝗮𝘁 𝘁𝗵𝗲 𝗳𝗼𝗹𝗹𝗼𝘄𝗶𝗻𝗴 𝘁𝗶𝗺𝗲𝘀: 22nd October at 4 pm CEST/ 10 am EDT / 7 am PDT 22nd October at 10 pm CEST/ 4 pm EDT / 1 pm PDT 23rd October at 1 am CEST/ 22nd October 7 pm EDT / 22nd October 4 pm PDT Sign up here: https://bit.ly/3YnQ7R0

𝗨𝗻𝗹𝗼𝗰𝗸 𝘁𝗵𝗲 𝘀𝗲𝗰𝗿𝗲𝘁𝘀 𝗼𝗳 𝗰𝗲𝗹𝗹 𝗱𝗲𝗮𝘁𝗵, l𝗮𝗯𝗲𝗹-𝗳𝗿𝗲𝗲 At Nanolive, our non-invasive imaging technology provides unique insights into the process of cell death, capturing key features of the process such as apoptotic membrane blebbing, cell swelling and vacuole formation. The following footage shows 3T3-derived pre-adipocyte cells undergoing cell death upon treatment with Ebastine.    Learn more about quantifying cell death label-free with Nanolive’s Live Cytotoxicity Assay here: https://bit.ly/3Y0QmAm #Nanolive #LabelFreeImaging #Microscopy #Cytotoxicity

𝗜𝗻𝗱𝘂𝘀𝘁𝗿𝘆 𝘄𝗲𝗯𝗶𝗻𝗮𝗿: 𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗖𝗮𝗿𝗱𝗶𝗼𝘁𝗼𝘅𝗶𝗰𝗶𝘁𝘆 𝗔𝘀𝘀𝗲𝘀𝘀𝗺𝗲𝗻𝘁 𝘄𝗶𝘁𝗵 𝗛𝗼𝗹𝗼𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝘆 Join us on October 22nd for a one-off webinar! Ambroise Garry, the Group Head for Global Investigative Toxicology within preclinical safety at Sanofi will present some of the work his team has carried out studying cardiotoxicity in human iPSC-derived cardiomyocytes. He will discuss data acquired using holotomography to study the cell responses to established drugs known primarily for inducing phospholipidosis, which may also trigger cell death. Topics covered: ·      Cardiovascular derisking with label-free live cell imaging ·      Drug-induced phospholipidosis ·      Label-free quantification of lipid droplets, lamellar bodies, and cytotoxicity evaluation in cells ·      IC50 calculation from live cell imaging ·      Doxorubicin-induced cardiotoxicity   Register here! https://bit.ly/47Z4j6s

𝗜𝘀 𝗽𝗵𝗼𝘁𝗼𝘁𝗼𝘅𝗶𝗰𝗶𝘁𝘆 𝗮 𝘀𝗶𝗴𝗻𝗶𝗳𝗶𝗰𝗮𝗻𝘁 𝗰𝗼𝗻𝗰𝗲𝗿𝗻 𝘄𝗵𝗲𝗻 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘆𝗼𝘂𝗿 𝗰𝗲𝗹𝗹𝘀? 🔬 Nanolive's solutions offer real-time, label-free imaging eliminating the need for fluorescence and its phototoxic effects. Our microscopes allow for live cell monitoring over hours under stable experimental conditions. This non-invasive imaging technology ensures that cells remain healthy and viable for downstream processes. Discover more about our live cell imaging platforms here: https://bit.ly/3ZUA6TV   #Nanolive #LiveCellImaging #LabelFree #Microscopy  

𝗢𝗰𝘁𝗼𝗯𝗲𝗿 𝗺𝗮𝗿𝗸𝘀 𝗕𝗿𝗲𝗮𝘀𝘁 𝗖𝗮𝗻𝗰𝗲𝗿 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗠𝗼𝗻𝘁𝗵 🌸 With 1 in 8 women worldwide being diagnosed with breast cancer, Breast Cancer Awareness Month is dedicated to raising awareness of the disease. This global initiative focuses on promoting screening, prevention, and educating the ones concerned on the signs and symptoms associated with the disease. At Nanolive, our label-free imaging technology contributes into advancing drug discovery and development, bringing researchers one step closer to finding a cure for breast cancer. In this example video, you can see an experimental antibody-drug treatment successfully killing breast cancer cells (right-hand video). Learn more about our technology here: https://bit.ly/3TXAOvP #BreastCancerAwarenessMonth #DrugDiscovery #LabelFreeImaging #Nanolive #Microscopy #LiveCellImaging

𝗜𝗻𝗱𝘂𝘀𝘁𝗿𝘆 𝘄𝗲𝗯𝗶𝗻𝗮𝗿: 𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗖𝗮𝗿𝗱𝗶𝗼𝘁𝗼𝘅𝗶𝗰𝗶𝘁𝘆 𝗔𝘀𝘀𝗲𝘀𝘀𝗺𝗲𝗻𝘁 𝘄𝗶𝘁𝗵 𝗛𝗼𝗹𝗼𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝘆 Join us on October 22nd for a one-off webinar! Ambroise Garry, the Group Head for Global Investigative Toxicology within preclinical safety at Sanofi will present some of the work his team has carried out studying cardiotoxicity in human iPSC-derived cardiomyocytes. He will discuss data acquired using holotomography to study the cell responses to established drugs known primarily for inducing phospholipidosis, which may also trigger cell death. Click below to read the full details! #webinar

𝗧𝗿𝗮𝗰𝗶𝗻𝗴 𝗰𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗯𝗲𝗵𝗮𝘃𝗶𝗼𝗿𝘀 𝗱𝗼𝘄𝗻 𝘁𝗼 𝗼𝗿𝗴𝗮𝗻𝗲𝗹𝗹𝗲 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 🔎 Nanolive’s label-free technology enables monitoring of entire cell populations down to the dynamics of organelles within single cells in real-time. Combined with our AI-powered image analysis platforms, we provide unique insights into cell morphology, confluency and the complex dynamics of intracellular organelles. This enables deeper understanding of phenotypic and functional characteristics of cells, enhancing more accurate results in research and innovation. Learn more about our technology here: https://bit.ly/4gE6dNP #AIImageAnalysis #LiveCellImaging #CellMorphology #LabelFreeTechnology #Nanolive #Microscopy 

𝐀𝐮𝐭𝐨𝐩𝐡𝐚𝐠𝐲: 𝐚 𝐛𝐢𝐨𝐥𝐨𝐠𝐢𝐜𝐚𝐥 𝐩𝐫𝐨𝐜𝐞𝐬𝐬 𝐨𝐟 𝐜𝐞𝐥𝐥 𝐝𝐞𝐚𝐭𝐡 𝐨𝐫 𝐜𝐞𝐥𝐥 𝐬𝐮𝐫𝐯𝐢𝐯𝐚𝐥 ❓ Autophagy is a cellular process essential for the maintenance of cellular homeostasis that involves the degradation and recycling of damaged organelles, proteins and other cellular components. Excessive autophagy can lead to cell death whereas dysregulation of it can be implicated in various diseases, including Alzheimer's and Parkinson's disease, or can even promote cancer cell survival. This video captures glioblastoma cells undergoing autophagy upon drug induction. At Nanolive, our label-free technology provides unique insights into the dynamic process of autophagy, capturing key steps such as engulfment of cytoplasmic materials, increase in vacuolation, organelle degradation, cell shrinking and cell to cell interactions. Understanding the dual role of autophagy in health and disease can help in the development of more targeted therapeutic strategies. Learn more about our technology : https://bit.ly/3N3QtpM #Nanolive #Microscopy #CellImaging #LabelFreeTechnology #HealthandDisease #AutophagyResearch #TargetedTherapies #Cancer #NeurodegenerativeDiseases