Parean Biotechnologies

I'll be in Roma next week for the European Society of Gene and Cell Therapy Congress on October 22nd, 23rd and 24th ! Let's meet to discover our fully integrated wetlab (flow cytometry, sorting and single cell omics) and datascience protocol, standardized, dedicated to in depth detection, selection, isolation and characterization of cell therapies. And many more tools available for cell therapy developers Reach out ! Valentin Quiniou Pierre Barennes Hang Phuong PHAM Parean Biotechnologies

🔬 Single-cell technologies are revolutionizing clinical trials. 🔬   The integration of single-cell analysis is transforming how we approach metastatic cancer treatments. A recent phase 2 study in BRAFV600E colorectal cancer highlighted the power of combining BRAF/MAPK inhibition with immune checkpoint blockade. Single Cell RNA-seq revealed crucial immune mechanisms within tumor cells that may explain why certain patients experience longer-lasting responses.   At Parean Biotechnologies, as official Certified Service Provider (CSP) of 10x Genomics, we are thrilled to contribute to these advances with our all-in-one solutions, which integrate cytometry, cell sorting, single-cell libraries, and advanced DataScience analysis. As an ISO9001-certified partner, our dedicated team of biologists, bioinformaticians, and biostatisticians is committed to accelerating your clinical research projects.   Single-cell technologies aren't just part of research publications; they are actively driving the future of precision medicine, offering new insights that enhance patient outcomes and reshape clinical research.   #SingleCell #RNAseq #ClinicalTrials #Immunotherapy #DataScience #PrecisionMedicine 10x Genomics, Parean Biotechnologies, Marwan TOUATI, Hang Phuong PHAM, Pierre Barennes

Discover our fully integrated Car-T cells protocol ! At Parean Biotechnologies, we've developed tailored wet lab and data science workflows, designed specifically for cell therapy developers. We are able to detect, select, isolate and fully characterize cell therapies, before and after infusion in patient. We're one of the few service providers in the EU offering a fully integrated solution, combining flow cytometry, cell sorting and single cell omics. This unique approach drastically enhance data quality and accelerates your program from discovery to clinical trial success. Key advantages for cell therapy developers: -> In Preclinical phases: optimize your innovation, strengthen your research, and prepare for a successful IND submission -> In Clinical phases: monitor treatment efficacy, gain critical patient insights, support regulatory submissions and reduce risks in your clinical plan. Ready to learn more ? check out our process here ! Valentin Quiniou Pierre Barennes Hang Phuong PHAM 10x Genomics

🔬🌟 Analysing Hepatic samples at the Single-Cell level with Parean Biotechnologies ! 🌟🔬 Yesterday, July 28th, was World Hepatitis Day. This date was chosen because it marks the birthday of Nobel Prize laureate Dr. Baruch Blumberg, who discovered the Hepatitis B virus and developed a test and vaccine against it. At Parean Biotechnologies, we celebrate our commitment to advancing scientific research for better liver health through our expertise in single-cell. 🧬 Single-Cell Hepatic Transcriptomics : our experts excel in generating and analysing data at a single-cell resolution, providing a detailed understanding of liver cell populations and their interactions. This fine-tuned approach helps us identify underlying mechanisms of liver diseases and develop targeted therapies. 🧭 Spatial Transcriptomics : by mapping gene expression directly within liver tissue, we offer unparalleled insights into the spatial organization of cells and their functional states. This revolutionary technology provides an essential overview for understanding the complexity of liver diseases. Join us in this scientific challenge and discover how our advanced technologies can transform your liver disease research. 📩 To learn more about our services and collaborations, contact us today! Parean Biotechnologies, Marwan TOUATI, Hang Phuong PHAM, Pierre Barennes, Louis Cabrieres, 10x Genomics, Sergine MONTUY #Hepatology #SingleCell #SpatialTranscriptomics #HepatitisB #DrBaruchBlumberg #BiomedicalResearch #InnovationsInScience #NobelPrize

Today, I was at Parean Biotechnologies in Saint-Malo. Thanks Valentin Quiniou and Pierre Barennes for a great time! Parean is now 10x Certified Service Provider for immune profiling. If you need help for your single cell project – experimental design / sample preparation (including cell sorting) / single cell workflow / library construction / data analysis-, don’t hesitate to contact them. For data analysis, they can offer bioinformatics and advanced analysis, especially in immuno-oncology. 

Exciting period for us over the past months with several papers (5+ !) published mentioning our Parean Biotechnologies team ! A new one here, on gamma delta T cells, exciting topic showcased by several biotech during conferences in London I attended early this year. Saying that we develop and master single cell and immune repertoire omics data science in various immunological & tumor settings is great....proving it by being cited as co authors of published papers with amazing academic researchers is even better !! Proud of our team ! 💪 More papers soon hopefully, stay tuned !

New Paper published on Gamma Delta T cells in PLOS Pathogens! Parean Biotechnologies team, Pierre Barennes, Valentin Quiniou and Hang Phuong PHAM are listed as co-authors, on this newly published paper, from Nathalie YARED & Myriam Capone, on long-lived memory gamma delta T-cells. Congrats to all authors ! This work is part of our contribution to Horus Project, and our data science workflow development since several months on rare populations such on gamma delta T cells, with scRNAseq, scTCRseq and scATACseq. More news coming soon on that matter ! "The involvement of γδ TCR-bearing lymphocytes in immunological memory has gained increasing interest due to their functional duality between adaptive and innate immunity. γδ T effector memory (TEM) and central memory (TCM) subsets have been identified, but their respective roles in memory responses are poorly understood. In the present study, we used subsequent mouse cytomegalovirus (MCMV) infections of αβ T cell deficient mice in order to analyze the memory potential of γδ T cells. As for CMV-specific αβ T cells, MCMV induced the accumulation of cytolytic, KLRG1+CX3CR1+ γδ TEM that principally localized in infected organ vasculature. Typifying T cell memory, γδ T cell expansion in organs and blood was higher after secondary viral challenge than after primary infection. Viral control upon MCMV reinfection was prevented when masking γδ T-cell receptor, and was associated with a preferential amplification of private and unfocused TCR δ chain repertoire composed of a combination of clonotypes expanded post-primary infection and, more unexpectedly, of novel expanded clonotypes. Finally, long-term-primed γδ TCM cells, but not γδ TEM cells, protected T cell-deficient hosts against MCMV-induced death upon adoptive transfer, probably through their ability to survive and to generate TEM in the recipient host. This better survival potential of TCM cells was confirmed by a detailed scRNASeq analysis of the two γδ T cell memory subsets which also revealed their similarity to classically adaptive αβ CD8 T cells. Overall, our study uncovered memory properties of long-lived TCM γδ T cells that confer protection in a chronic infection, highlighting the interest of this T cell subset in vaccination approaches." Marwan TOUATI Valentin Quiniou Hang Phuong PHAM Pierre Barennes https://lnkd.in/epeNgV2j

Want to discover our deliverables for a data science mission on single cell RNAseq ? here you go ! https://lnkd.in/eCzsXkGp Our team is continuously working on our mission reports, to standardize (as much as possible) our biostatistics workflows, ease reading for biologists, and hence speed up result interpretation. Here above is an example of a scRNAseq bio-informatics and bio-statistics report, on TILs, generated from a publicly available data sets (click on the link in comments for details) There are five levels of analysis available at Parean for single cell data science, depending of our client's needs: - Level 1: PreProcessing (free for project including wet lab operations) - Level 2: Standard analysis (counting data, dimension reduction, graphs...) - Level 3: Advanced analysis (cluster annotation, ORA, differential tests ..) - Level 4: Advanced analysis with >3 conditions, 1 comparable public data set and 1 specific signature test - Level 5: fully custom, multiple conditions, multiple public data sets and specific signatures Check our (new) website for more details, and reach out ! Huge thanks to Hang Phuong PHAM for leading such initiatives at Parean Biotechnologies and Louis Cabrieres for his major contribution Valentin Quiniou Pierre Barennes Hang Phuong PHAM Louis Cabrieres Parean Biotechnologies

We are thrilled to announce that Parean Biotechnologies is now officially a 10x Genomics Certified Service Provider (CSP) for #singlecell immune profiling. As a leading Europe-based service provider, Parean Biotechnologies specializes in supporting #immunology and oncology research. With their cutting-edge, fully integrated bioassays, wet lab, and advanced data science expertise, they offer tailored solutions to biotech companies and researchers. Find a 10x Genomics Certified Service Provider for your research needs here: https://lnkd.in/e8yhSupj

Parean Biotechnologies is now listed on Scientist.com platform ! Many of our customers ask us to register on this platform, to comply with their internal process, so...here it is ! Here are the link to our company profile: https://lnkd.in/e9a-Srdj Get access to all our services such as cytometry and cell sorting using dextramers and custom panels, single cell RNAseq, immune profiling data science, ... Marwan TOUATI Valentin Quiniou Hang Phuong PHAM Pierre Barennes