Immagina Biotechnology S.r.l.

Are you attending Bio-Europe 2024? If so, meet and connect with our CEO in Stockholm! Massimiliano Clamer is looking forward to showcase our broad set of translatome solutions and explore potential business opportunities with other biotech and pharma companies. You can schedule a meeting with him via the Bio-Europe networking platform, or simply drop a message at https://zurl.co/NF1w. Can't wait to discuss with you! #BIOEurope

Are cytokines, tumors and ribosomes speaking the same language? It probably comes as no surprise that tumors evolve to avoid immunological responses. Initially, T cells infiltrate in the tumor microenvironment (TME), successfully killing tumor cells and secreting pro-inflammatory cytokines. IFNγ, for example, promotes further anti-tumoral responses by altering transcription of the cells it targets. But what’s happening on the translatomic level? No studies seemed to address the topic, until this week. Using ribosome profiling, Anna D. et al. identified a subset of ribosomes, P-stalk ribosomes (PSRs), that are assembled in response to tumor-specific cytokines. Interestingly, PSRs mainly translate mRNAs that code for transmembrane proteins, facilitating the recognition of tumor cells by the immune system. In fact, knock-down of PSRs decreased tumor cell recognition and death mediated by CD8+ T cells, whilst increase in inhibitory cytokines (TGFβ) impaired PSR function. Overall, the authors concluded that PSRs interact directly with cytokines, making them key players in the tumor microenvironment. Now that we know that ribosomes, cytokines and tumors are speaking the same language, it will be easier to find therapeutics that can help in the fight against cancer. To reach this conclusion, the authors used ribosome profiling, following a traditional approach. At Immagina, we offer a wide range of RiboSeq gel free solutions, that save time and avoid the need for bulky equipment. For more information visit https://zurl.co/WyLA Link to the full paper: https://zurl.co/xgK7

Last week, Immagina attended "The complex life of RNA" in Heidelberg. It was great to showcase our solutions in the double-helix building! During the conference, we heard that EMBL celebrates its 50th birthday this year, and we would like to say happy birthday 🥳 50 years of excellent science conducted in Europe, but with impact in scientists all over the world. At Immagina, we're also proud to empower researchers worldwide with our cutting-edge translatomic solutions. Learn more here: https://zurl.co/DZDn #EMBL50 #EESRNA #mRNA #RNA

EMBL’s first Industry Day was a success, and it won’t be the last! On 14 October, EMBL hosted representatives of 14 leading pharmaceutical and biotech companies for an afternoon of networking and scientific exchange on innovative products, advanced technologies, sustainability plans, and career options. It was an excellent chance for EMBL scientists to meet the providers of their cutting-edge research tools, and learn more about new instruments, greener products, ground-breaking technologies, and job opportunities. Read more here 👉 https://lnkd.in/dR_CKxwC

It's not everyday that a company completes 10 years of existence. Last week, during our company retreat, we celebrated the occasion. Everyone also had the chance to present their contributions to the company with a main focus on Q4 results + 2025 actions. We're proud of what we've achieved so far, here's to 10 more years!🥂🤩 #10years #anniversary

Immagina is attending "The complex life of RNA" https://zurl.co/wkdJ EMBL in Heidelberg this week! Make sure to come meet us there and learn more about our translatome solutions 🧬🔬

It’s a great week for RNA! Congratulations to Victor Ambros (University of Massachusetts Chan Medical School), and Gary Ruvkun (Harvard Medical School) on their 2024 Nobel Prize Award in Physiology or Medicine for the discovery of microRNAs and their key role in gene regulation. Dive deep into translation using active ribosome profiling https://zurl.co/1ua1. Imagine what you can discover. #NobelPrize #microRNA #ribosome

Register now & submit abstracts (deadline December 8, 2024) for the #Swiss #RNA Workshop on January 24, 2025, starting at 09:15 at the University of Bern Keynote Speakers: Eva Maria Novoa, Andrea Pauli and Robert Schneider. Short talks selected from abstracts. Registration is free of charge. https://lnkd.in/e9mGyXcQ Please help spread the word! Thanks a lot to the sponsors for their support: Merck Life Science Immagina Biotechnology S.r.l. HUBERLAB. AG Takara Bio Europe Promega Switzerland Thermo Fisher Scientific Aldevron Maria Hondele Oliver Mühlemann Swiss National Science Foundation SNSF

It was great to attend the #RNACanadaARN conference in Ottawa last week! It was a pleasure to listen, learn, and interact with inspiring students and scientists. Grateful for the opportunity to discuss how our translational platform can support basic science and new therapeutics!

Are tRNAs the secret heroes of the nervous system? They might be. In a recent study of Kapur et al https://zurl.co/hQpG from the Susan Ackerman lab, they assessed #tRNA expression in a wide range of nervous system cell types – a big challenge due to the complexity of the brain and tRNA molecule. What posed a challenge before was elegantly overcome by the group, which developed a mouse model with modified Pol III, the enzyme mainly responsible for tRNA synthesis, to determine tRNA expression in different nervous system cell types. Interestingly, the scientists observed that tRNAs varied greatly between nervous system cell types, despite often belonging to the same families. They then focused on 2 specific families of tRNAs, tRNA-Arg(TCT) and tRNA-Ile(TAT), to assess the impact of their depletion on the tRNA pool and cell viability. Mice with full loss of tRNA-Arg-TCT-4-1 struggled to restore the tRNA pool, despite compensatory production of other types of tRNA-Arg(TCT). Mutations in the tRNA-Ile(TAT) family were correlated to the death of neurons in the cerebellum, highlighting the contribution of this type of tRNA to cell viability. Overall, an interesting study on the role of tRNA in the nervous system. At Immagina, we have our own method for detection of tRNA abundance and chemical modifications. Available now as a service https://zurl.co/S8Dm and coming soon with a different format 👀 Stay tunned! #RNA #neurology #neuroscience