Cradle will attend PEGS Europe in Barcelona next week (November 5-7th)! 🎤 Join Stef (CEO & cofounder) on Wednesday November 6th at 14:50 when he discusses several real-world antibody, vaccine and enzyme case studies to highlight which limitations Cradle had to overcome to build a robust, scalable and easy-to-use generative system for protein design 🤓 Visit Poster B033 (or ping us) to nerd out about multi-property, multi-stage generative protein design with Harmen (Head of Bioengineering & cofounder), Richard (Scientist - Bioengineering), Jinel (Scientist - Bioengineering), Jonathan (Scientist - Machine Learning), Tilke (Head of Product) and Thijs (Partnerships) ☕ Ping Thijs (Partnerships) at thijs@cradle.bio if you're interest to learn how to get started with Cradle's generative ML platform. #PEGSEurope #generative #AI #ML #proteins #biologics #conference
Over ons
We believe Cells can theoretically produce almost anything, from fabrics to food, fuel and medicines. Designing cell-factories is hard, but our tools and machine-learning models can make it easier. Our mission is to ultimately help replace traditional farms and factories for a more sustainable world. Jobs: https://jobs.cradle.bio
- Website
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http://www.cradle.bio
Externe link voor Cradle
- Branche
- Biotechnologie
- Bedrijfsgrootte
- 11 - 50 medewerkers
- Hoofdkantoor
- Amsterdam
- Type
- Particuliere onderneming
- Opgericht
- 2021
- Specialismen
- protein design, machine learning, protein activity, protein stability, protein secretability, protein , protein structure, metabolic engineering, protein engineering en protein solubility
Locaties
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Primair
Routebeschrijving
Amsterdam, NL
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Routebeschrijving
Zurich, CH
Medewerkers van Cradle
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Tilke Judd
Founding Product Manager @ Cradle | ex-Google | MIT PhD
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Nick Lenten
Founder & CEO Ahead | ex-CPO Google Flights and Coolblue
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Cynthia Jurytko
Investor & advisor with a mission to create positive system change.
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Noé Lutz
Senior Engineering Leader | Machine Learning and Security Expert | Xoogler
Updates
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We held a protein-engineering challenge at iGEM, and it was a lot of fun 🔥❤️
We just wrapped up an amazing protein engineering challenge at IGEM, one of my favourite events of the year. Our booth was full of students eager to try their hand at designing thermally stable proteins, which would be judged by Cradle's AI models (predictor models that predict thermostability). Over 100 students jumped into the challenge, and it was super inspiring to see their strategies. Some fired up PyMOL for rational design, while others gambled with random mutations. Then there were the creative hackers - one team found a thermostable protein in the literature and practically rewrote it, another maxed out their design with disulfide bonds, and the University of Münster team even spent the night training on a public thermostability dataset! The University of Pisa dominated much of day two, collaborating as a team to combine beneficial mutations and holding the top three spots. But then came the final sprint - Nienke IJspeert from Leiden University showed up with some smart rational nanobody designs that, while landing in fourth place, sparked renewed motivation. Inspired by this, Matias Brezina Borges from University of Munich (who wished he'd found us sooner!) dove into PyMOL and produced our winning design. Second place went to a great collaborative effort - we gave Michel Stevens from University of Münster another shot after seeing how much work he'd put in with his teammates (they even used their own models!). They grabbed silver, while Riccardo Masetti from University of Pisa held onto third place. It was a lot of fun to see the excitement around the challenge and Cradle's approach - we spent every minute talking about models and throughput. Between the creative strategies, overnight modeling attempts, and last-minute victories, we couldn't have asked for a better way to showcase protein engineering at IGEM. Congrats to the winners! If you want to know more about protein engineering and how we do it at Cradle, stop by the talk with Daan van der Vorm and me tomorrow at Plaza 3 at 12:45!
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"AI is reshaping software, both in how it's written and what it can do. This is creating new opportunities for growth and efficiency, and tackling novel challenges. This impact will only increase in the years to come." -- Accel Accel has released its Euroscape 2024 report, an annual overview of the top 100 European companies valued under $1 billion (includes Cradle ❤️). A key insight from the report is the increasing traction of vertical AI applications among enterprise users, i.e. AI x Biotech. As the report suggests, this intersection of specialized knowledge and AI is will drive significant innovation in the coming years. 👉 report: https://lnkd.in/eSpyZTdg
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Stef will be in London next week for Benchling's Benchtalk! He will be participating in a panel discussion on 'Accelerating R&D with AI'. Session is Wednesday, October 23rd, 10:55 AM at the Convene Space. Pierre Salvy, CTO at Cambrium and Stef will discuss how companies can turn the omnipresent conversations about AI into concrete projects, and the key role that data quality plays when it comes to operational success. If you're interested in attending, you can register here: https://lnkd.in/dWqVGp4J
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There are many 'Hot Startups Lists', but WIRED's Top 100s will always have a special place in our heart. This time we're celebrating being featured amongst the amazing startups in Europe, and a special section dedicated to Amsterdam's ecosystem. (Did you know there are more than 4000 startups in Amsterdam?) Wired notes that what sets Amsterdam apart is its strong focus on tackling urgent societal issues and global challenges. From energy transition to pollution, climate change and addressing the needs of a growing population, Amsterdam's startups are increasingly innovating with a strong purpose. Hence our friends from Amsterdam that were also selected for the list: Overstory: Using satellite imagery to prevent power outages and wildfires. Monumental: Revolutionizing construction with autonomous bricklaying robots. Carbon Equity: Democratizing access to climate tech investments. Coolgradient: Optimizing data center energy efficiency. Weaviate: Powering AI applications with vector database technology. Bloom & Wolf: Offering sustainable alternatives to traditional cut flowers. Solvimon: Streamlining billing for fintech and SaaS businesses. Haaven: Simplifying the process of building eco-friendly tiny houses. Keep it going! 🚀
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Don't you hate it when UPS just leaves your package in front of your door? 😅 Richard (using some quantum mechanics) to unpack our latest toy: a Carterra. Once we get it to our lab, it will allow us to take our high-throughput antibody screening & characterisation to the next level. Update: it's already running! ❤️🔥
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Congratulations to David Baker, Demis Hassabis and John Jumper for winning the Nobel Prize in Chemistry! Their groundbreaking work has inspired many of us to pursue careers in protein engineering and computational biology, and have opened up new frontiers in drug discovery and biotech. Thank you!
BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 Nobel Prize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.” The Nobel Prize in Chemistry 2024 is about proteins, life’s ingenious chemical tools. David Baker has succeeded with the almost impossible feat of building entirely new kinds of proteins. Demis Hassabis and John Jumper have developed an AI model to solve a 50-year-old problem: predicting proteins’ complex structures. These discoveries hold enormous potential. The diversity of life testifies to proteins’ amazing capacity as chemical tools. They control and drive all the chemical reactions that together are the basis of life. Proteins also function as hormones, signal substances, antibodies and the building blocks of different tissues. Proteins generally consist of 20 different amino acids, which can be described as life’s building blocks. In 2003, David Baker succeeded in using these blocks to design a new protein that was unlike any other protein. Since then, his research group has produced one imaginative protein creation after another, including proteins that can be used as pharmaceuticals, vaccines, nanomaterials and tiny sensors. The second discovery concerns the prediction of protein structures. In proteins, amino acids are linked together in long strings that fold up to make a three-dimensional structure, which is decisive for the protein’s function. Since the 1970s, researchers had tried to predict protein structures from amino acid sequences, but this was notoriously difficult. However, four years ago, there was a stunning breakthrough. In 2020, Demis Hassabis and John Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic. Life could not exist without proteins. That we can now predict protein structures and design our own proteins confers the greatest benefit to humankind. Learn more Press release: https://bit.ly/3TM8oVs Popular information: https://bit.ly/3XYHZGp Advanced information: https://bit.ly/4ewMBta
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We are happy to announce that we are partnering with iGEM Community for the iGEM Competition. As sponsors, we're supporting iGEM's global platform for synthetic biology education and innovation. The iGEM Competition encourages students to develop innovative solutions to real-world problems using synthetic biology. We believe that AI will significantly accelerate progress in this field, and we're keen to see the creative approaches that participants will bring to the competition. Our team members, Daan and Michelle, will be attending the 2024 iGEM Grand Jamboree in Paris from October 23-25, and they are excited to share our strategies and learnings from the lab with the iGEM community, and particularly share how we're using AI to accelerate protein design. They will give a presentation on how to use automated high-throughput workflows in your own lab on Friday, October 25th at 12:45 CEST. Stop by our booth if you want to try your hand at your own protein designs, and see how they size up against our models!
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