Syncell Inc

The buildup of misfolded protein aggregates is a key feature of neurodegenerative diseases like Alzheimer's. These aggregates contribute to a toxic cellular environment, driving disease progression. Identifying the specific proteins involved is essential for developing effective treatments. However, despite current knowledge, our understanding of the proteome within Aβ aggregates and their interactions remains incomplete. Existing spatial proteomics methods often rely on antibody arrays, limiting de novo proteomic discovery with precision. At Neuroscience 2024, our scientist CHIEN-CHANG HUANG will present findings from a study using the Microscoop system. This research uncovered both known and novel Aβ-associated proteins, including two newly identified proteins that colocalize with Aβ1-42. These findings were confirmed by antibody staining and further validated using brain sections from the 5XFAD mouse model of familial Alzheimer's disease. Can't make it to the event? No worries! You can still access the poster by reaching out to us. For more information, visit Syncell's contact page 👉 : https://lnkd.in/gShzeQid. #SfN2024 #alzheimersdisease #alzheimersdiseaseresearch #targetidentification #Syncell #Neuroscience2024

Curious about the 80+ protein species at primary cilia distal tips or the 100+ at lipid-mitochondrial interfaces? Or perhaps you're interested in uncovering the complete proteome of any cell or subcellular organelle? Discover Microscoop® by Syncell—a revolutionary technology that overcomes the limitations of proximity ligation, laser capture microscopy, and antibody-based proteomics with an unbiased, subcellular solution. Join us at booth #32 at HUPO 2024 and learn how Syncell can elevate your research by providing deeper insights into the human proteome. #HUPO2024 #Proteomics #SpatialBiology #BiotechInnovation #SubcellularDiscovery

Struggling with proteomic challenges in neuroscience? You're not alone. Precise localization of proteins at the subcellular or synaptic level often proves difficult, limiting insights into neural processes. Detecting low-abundance proteins without interference from more abundant ones is also a significant hurdle. Brain tissue preservation methods, such as FFPE, can compromise data quality, making protein extraction harder. Identifying disease-specific biomarkers for conditions like Alzheimer's and Parkinson's is further complicated by overlapping protein profiles, while current spatial proteomics methods, relying on pre-defined antibodies, add both cost and time to the process. If these challenges resonate, Microscoop® by Syncell offers a solution. It enables de novo protein identification from specific cell compartments and microenvironments, directly extracting proteins for mass spectrometry analysis to reveal novel proteins with subcellular precision and uncover new insights into cellular processes. 📢 Join us for a product theater talk with Dr. Jung-Chi Liao at Neuroscience 2024 on October 7th, 2024, at 1 PM, and learn how Microscoop® can overcome these obstacles and accelerate your research. Looking forward to seeing you there!🙌 #SfN2024 #aggregates #biomarkerresearch #targetidentification #Syncell #Neuroscience2024

Misfolded protein aggregates are a hallmark of neurodegenerative conditions like Alzheimer's, Parkinson's, ALS, and Huntington's disease, creating toxic environments that drive disease progression. For example, Alzheimer's disease is marked by β-amyloid plaques and tau tangles that disrupt brain function, while Parkinson's disease features α-synuclein aggregates known as Lewy bodies. Understanding these protein aggregates is crucial for developing effective treatments for these challenging conditions. The blog explores a new spatial proteomics discovery technique that enables researchers to pinpoint the exact location and composition of protein aggregates within diseased tissues. Read more - https://lnkd.in/gEjdyz6E

Join us at SfN2024 to explore Syncell's Microscoop®, the first instrument capable of resolving the entire proteome at subcellular resolution in a spatial context. Microscoop® improves the dynamic range of proteomic data in mass spectrometry without needing antibodies, enabling truly unbiased analysis. It has revealed novel protein constituents, such as β-amyloids and TDP-43 aggregates, across various sample types, including FFPE human brain tissue. Stop by booth #606 to meet our Application Manager, Weng Man Chong, and Senior Application Scientist, CHIEN-CHANG HUANG, and discover how Microscoop® is accelerating neuroscience research. If you're unable to attend the event, don't worry! You can still explore more details by checking out our Resources & References.👉 https://lnkd.in/gHYp5CKC #SfN2024 #Neuroscience2024 #ProteomicDiscovery #Syncell

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects behavior, cognition, learning, and memory in older adults. Research led by Dr. Rodrigue at the Center for Vital Longevity shows that Aβ burden increases steadily from ages 30 to 89 in healthy individuals. Despite this knowledge, our understanding of the proteome of Aβ aggregates and their interactions with associated proteins remains incomplete. Current spatial proteomics methods often rely on antibody arrays, limiting de novo proteomic discovery with precision. At the FASEB conference on Cellular and Molecular Mechanisms of Brain Aging, our scientist Mei Zhang will present findings from a study utilizing the Microscoop system, which uncovered both known and novel Aβ-associated proteins. Among these, two newly identified proteins were found to colocalize with Aβ1-42, confirmed through antibody staining and further validated using brain sections from the 5XFAD mouse model for familial Alzheimer's disease. If you're unable to attend the event, don't worry! You can still access the poster by contacting us directly. Visit Syncell's contact page for more information.👉 https://lnkd.in/gShzeQid #alzheimersdisease #alzheimersdiseaseresearch #brainhealth #aging #targetidentification #Syncell

Our Syncell team recently took a break from the usual work routine for a fun and productive team-building day! New and existing members connected over various activities and bonded as they worked together on carefully crafted challenges. We also took the opportunity to celebrate our August birthdays together. It was a fantastic day filled with teamwork, laughter, and a stronger sense of community as we continue to grow rapidly. Here's to more moments like these! 🎉 #TeamBuilding #Syncell

Discover the future of protein extraction in our blog as we delve into the innovative realm of Laser Nano-Pulldown (LNP) technology. While laser capture microdissection has served as a cornerstone in cellular research, LNP emerges as a transformative approach, setting a new benchmark for precision and efficiency.    🎯 Precision at the Heart of Discovery  LNP targets proteins within discrete cell components or subcellular domains. Our technology doesn't just facilitate observation – it isolates with the finesse required for organelle-level molecular analysis.    🌟 Why Choose LNP by Microscoop?  - Enhanced Precision: LNP's laser accuracy and nanoscale process transcend traditional limitations.  - Organelle-Level Isolation: Distinct cellular territories for detailed study.  - Streamlined Efficiency: Achieve more in less time with Microscoop's advanced capabilities.    Read more : https://lnkd.in/gHgRcn-M #SyncellMicroscoop #LaserNanoPulldown #ProteinPurification #Microscoop

We're excited to announce the appointment of Philippe Lyko as Chief Financial Officer (CFO) and Nikhil Rao, PhD, as Senior Vice President of Commercial. Their experience and vision will be key as we drive Syncell into its next phase of growth and commercial success. Read full article - https://lnkd.in/eHfWrehe #SyncellTeam #Hiring #Proteomics