Lhasa Limited

We had a great day yesterday connecting with the scientific community at the Lhasa Japan symposium in Tokyo! Thank you to our expert industry and regulatory speakers and to everyone who attended. Watch this short video for an insight into the day! 🎥🎬🇯🇵 #insilico #pharma #japanpharma #nitrosamines Consult Lhasa

Would you like to learn more about using purge scoring to evaluate impurity carry over in your drug development workflow? This week we discuss reactivity purge: ☑️ Reactivity predictions are provided by Mirabilis based on the actual reagents and conditions used in your synthetic route. ☑️ The reactivity predictions within Mirabilis are peer-reviewed by expert scientists and based on published knowledge cited within the report provided. ☑️ The methodology behind the ‘conditions-approach', is explained in an insightful publication from OPRD: https://buff.ly/3z0ADc3

Introducing our next speaker for our upcoming webinar 'Leachables sensitisation assessment framework in collaboration with ELSIE' in Japanese. 👏 Geraldine is a computational toxicologist in the Non Clinical Safety organisation at GSK since 2014. She is a registered toxicologist and has a background in the use of in silico modelling platforms to meet the expectations of the ICH M7 mutagenic impurities regulatory guideline, the ICH Q3A, B & C non-mutagenic impurity guidelines, and extractable and leachable risk assessments. Geraldine is a representative for GSK on the ELSIE consortium where she is co-chair of the sensitisation subteam. Join us: 📅 2024年10月1日 |🕙 3-5pm JST | https://buff.ly/3LZuzn3 #Japan #extractables #leachables #webinar #ELSIE

Will we see you at the 5th COLAMA meeting in the city of Bogotá, Colombia? Application Scientists Lucia Toscano and Maria Celeste del Fueyo will be holding an industry hosted session, on the 19th of September at 12pm discussing the use of in silico tools in toxicology, focusing on: ➡️ How you can identify potential degradation impurities in your drug development workflow using our software solution Zeneth. ➡️ How to classify potentially mutagenic impurities through our expert rule-based & statistical-based systems, Derek Nexus and Sarah Nexus. For more information on V #COLAMA and how to attend, click here: https://buff.ly/3WGSpZA #DerekNexus #Zeneth #SarahNexus #InSilico #COLAMA2024 #Toxicology

Developmental and reproductive toxicity (DART) is an area of #toxicology that is required to assess the impact of new chemicals on adult fertility and embryo development. Industries rely on DART assessments to safeguard human health, adhering to regulatory standards like those outlined in the #ICHS5 guideline. However, the current regulatory landscape for DART assessments is not without its challenges. Traditional methods rely heavily on animal testing, which comes with significant ethical concerns, high costs, and limited insights into the underlying mechanisms of toxicity. 🧬 📝 Our latest #research details an alternative approach to animal testing, which can be used to screen for DART hazards at the early stages of compound development. This work highlights a step forward in animal-free safety assessments, with the potential to aid regulatory DART-based safety assessments. Read our #blog to learn more about this publication, and take advantage of 50 days #OpenAccess https://buff.ly/3Xp2UlP #Science #AnimalFree #InSilico #Tox

Conducting a Weight-of-Evidence (WoE) assessment to meet ICH S1B(R1) can be challenging due to the sheer volume of data that needs to be interpreted. 📚   #Kaptis streamlines this process by integrating Adverse Outcome Pathways (#AOPs) with advanced reasoning to organise and contextualise information, delivering clear and data-driven outcomes. Additionally, the ICH S1 classification functionality in Kaptis enables swift navigation through #WoE assessments by considering the six key factors outlined in the #ICHS1B addendum.   To learn how Kaptis can streamline your #carcinogenicity assessments, get in touch: https://bit.ly/3ATTzd6 #Software #Data #InSilico

🤚Are you looking forward to the Leeds Digital Festival? Join us for our event, 'Exploring Scientific Software Architecture'. 💻 In this Architecture Kata, which is co-hosted with Codurance, attendees will be split into teams and presented with a business problem/use case related to scientific solution architecture to solve in groups. Within these groups, you’ll have an opportunity to design a solution architecture to meet that problem context before showcasing this work to the wider group. Taking place at the Lhasa Head Office, this is an excellent opportunity to try out Solution Architecture in a collaborative, supportive, and fun environment. 📅 24th September 🕜 18:00 - 20:00 ✏️ Register to attend: https://buff.ly/4dhWmuJ #Tech #LDF2024 #Architecture #Workshop #LeedsDigital

Meet the first speaker for our upcoming webinar 'Leachables sensitisation assessment framework in collaboration with ELSIE' in Japanese. 👋 Patricia Parris (Trish) joined Pfizer in February 2020 as a Global Risk Assessment Services Toxicologist in Drug Safety R&D. Trish has a background in Genetic Toxicology and over the last 14 years has built expertise in mutagenic impurity, extractable and leachable, and contamination risk assessments. She is currently Rapporteur for ICH Q3E: Assessment and Control of Extractables and Leachables in Pharmaceuticals and Biologics and is Chair of the ELSIE Board of Directors. The webinar will take place on: 📅 2024年10月1日 🕙 3-5pm JST Register today: https://buff.ly/3LZuzn3 #Japan #extractables #leachables #webinar #ELSIE

Did you hear about our latest enhancement to Sarah Nexus? 👀 We've introduced a new #ChromosomeDamage prediction model, which enables you to perform comprehensive #genotoxic assessments by supporting mutagenicity and chromosome damage predictions within a single, powerful in silico platform. The model leverages in vitro chromosome aberration and micronucleus assay data, alongside in vivo test data, offering a robust and reliable tool for assessing genotoxic risk. For more info on how to sponsor this additional module, get in touch: https://buff.ly/3Xh3Nvk 👈 #SarahNexus #InSilico #Genotoxicity

Happening today! 🇩🇰 If you’re at EUROTOX Congress 2024, don’t miss our session on accelerating safety assessments for carcinogenicity and other endpoints using NAMs. #Eurotox2024 #InSilico #Toxicology