Bruker Fluorescence Microscopy

📸 𝗣𝗵𝗼𝘁𝗼𝗱𝗮𝗺𝗮𝗴𝗶𝗻𝗴, 𝘂𝗻𝗰𝗮𝗴𝗶𝗻𝗴, 𝗼𝗽𝘁𝗼𝗴𝗲𝗻𝗲𝘁𝗶𝗰𝘀, 𝗮𝗻𝗱 𝗺𝗼𝗿𝗲! The Acquifer Imaging Machine (IM) has an add-on photomanipulation module for researchers interested in performing advanced experiments with ease. This module is an optional hardware upgrade to the fully automated widefield microscope and has a robust, optomechanical design with moving optics and a stationary sample holder. This module is automatically positioned under your sample before it annotates and automatically photomanipulates full datasets of entire microplates. This makes many experiments possible such as monitoring immune responses to injury or tissue-specific compound activity. The photomanipulation module has several important applications and was used to monitor white blood cell, specifically neutrophil, migration after automated laser injury. This image data was generated by INFLANET ESRs Nils Olijhoek (Stephen Renshaw and Phil Elks labs, University of Sheffield) and Sankeert Satheesan (Acquifer). #immunology #lifescience #photomanipulation

🚨 𝗙𝗶𝗻𝗱 𝘂𝘀 𝗼𝗻 𝗬𝗼𝘂𝗧𝘂𝗯𝗲! 🚨 ▶️ https://lnkd.in/dBCM85uR Did you know you can find highlights from past webinars, demos, and product videos over on our Fluorescence Microscopy YouTube channel? Give it a look and make sure to subscribe! #lifesciences #microscopy #neuroscience

Having a blast! 🎉

👋 Our next expert behind the keyboard that we want to highlight is Product Manager, Yasaman Akhavan. Yasaman is great at bringing lots of interesting miniscope information and imagery to this page! 🎓 Yasaman has a M.Sc in Biomedical Engineering from SUNY University at Buffalo and an MBA from The Lisbon MBA Católica | Nova 🎵 Outside of work, Yasaman enjoys traveling, woodworking, and music. ✉ We encourage you to reach out to her if you’re interested in any of her work! ⬇ Learn more about Yasaman below. ⬇ ❓ What do you love about your job? 💬 One of the things I love about being a product manager is the journey of transforming raw customer insights and pain points into innovative solutions and a clear product vision. It’s not just about the technical aspects; there’s a great deal of creativity involved in shaping these ideas until they truly resonate with users, and that brings me so much joy. This process is deeply collaborative, allowing me to work closely with different departments—sales, #engineering, science, support, and marketing, .... Especially here at Inscopix, it means collaborating with exceptionally bright and passionate people, which makes every day more exciting. ❓ What do you think is unique about the scientific community within your field? 💬 We are talking about the #neuroscience community—a group of passionate individuals who are not only dedicated to unlocking the brain’s secrets but also to applying this knowledge in ways that can reduce suffering and improve quality of life. This translational power that the neuroscience community's research holds is what makes it so impactful and unique—it’s a field where discoveries in the lab can quickly translate into #therapies, interventions, and tools that address the very challenges we, or those around us, are facing. ❓ What is something your BU’s technology does that is unique to Bruker products? 💬 One of the aspects I find most unique about Inscopix technology is the holistic environment it creates for miniscope research. It’s not just about the ability to observe neural dynamics in naturalistic settings; the Inscopix environment offers nearly everything you need—from surgical procedures to data acquisition and analysis. This comprehensive support at every step of the research process is what truly makes Inscopix stand out in the field. But what really resonates with me is the deep commitment to putting the researcher first. The Inscopix miniscope was built by neuroscientists for the neuroscience community, and this careful attention to the specific needs of researchers is evident in every aspect of the technology. It’s designed with a deep understanding of what researchers genuinely want, and that makes all the difference. ❓ What are some of your hobbies outside of work? 💬 Traveling, Crossfit, and Woodworking. Music is also a big part of my life, and while I don’t play any instruments, I’m in the process of learning the handpan.

🧠 𝗨𝗻𝗰𝗼𝘃𝗲𝗿 𝗻𝗼𝘃𝗲𝗹 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰𝘀 𝗳𝗼𝗿 𝗱𝗲𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 ▶️ https://lnkd.in/gt3rAHuJ In this exciting Inscopix, Inc. webinar, a special guest will unveil the newest findings from a project conducted through the Inscopix Discovery Lab, providing a real-world example of the application of Inscopix miniscope technology to further drug development. In addition, hear more from Dr. Jonathan Nassi on the cutting-edge in vivo imaging assay from the Inscopix Discovery Lab. This innovative approach incorporates miniscope imaging with active behavior to facilitate preclinical pharma studies assessing novel compounds. #depression #neuroscience #Therapeutics #miniscope

We had a great time earlier this month at the Cold Spring Harbor Laboratory neuro course. Students were able to look at dendritic activity in layer 2/3 of visual cortex on a Bruker multiphoton system. Specifically, visual gratings were presented to a mouse and calcium dynamics were imaged in visual cortex. Thanks for having us! #MicroscopyMonday #neuroscience #lifesciences

💊 𝗨𝗻𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗡𝗲𝘄 𝗙𝗿𝗼𝗻𝘁𝗶𝗲𝗿𝘀 𝗶𝗻 𝗠𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆: 𝗘𝗻𝗵𝗮𝗻𝗰𝗶𝗻𝗴 𝗥𝗲𝘀𝗲𝗮𝗿𝗰𝗵, 𝗗𝗿𝘂𝗴 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁, 𝗮𝗻𝗱 𝗗𝗶𝗮𝗴𝗻𝗼𝘀𝘁𝗶𝗰𝘀 Watch: https://lnkd.in/djBeSB3j 🖥️ In this on-demand webinar, Prof. Dr. Nicole Endlich gives an overview of her research on kidney disease and the development of new diagnostic tools. She speaks on: • Developing high-content screening methods based on a zebrafish larvae model for the identification of potential therapeutic agents • Combing super resolution-based imaging techniques with multiplex staining and in situ hybridization for the advanced visualization of structure and morphology 🔽 In the below clip, Dr. Endlich discusses how their lab established an animal disease model before scaling to high-content screening. This approach enables them to automatically detect vasculature and rapidly detect proteinuria. #pharmaceuticals #disease #Screening

💡 𝗔𝗰𝗾𝘂𝗶𝗿𝗲 𝗹𝗮𝗿𝗴𝗲 𝘀𝗮𝗺𝗽𝗹𝗲 𝗱𝗮𝘁𝗮 𝘄𝗶𝘁𝗵 𝗵𝗶𝗴𝗵 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝘂𝘀𝗶𝗻𝗴 𝘁𝗵𝗲 𝗧𝗶𝗹𝗲𝗡𝗮𝘃𝗶𝗴𝗮𝘁𝗼𝗿 𝗠𝗼𝗱𝘂𝗹𝗲. This software module allows users to draw regions of interest (ROIs), which can optimize the trade-off between the amount of data acquired and capturing the features of interest. Similarly, multi-position experiments using TileNavigator can optimize data acquisition and save time. Find out more: https://lnkd.in/esxTgd5p #MicroscopyMonday #software #image #microscopy

Imagine peeking inside a live, freely-behaving, thinking brain and watching neurons light up. Sounds like science fiction? Thanks to the Inscopix, Inc. miniscope, it is now a scientific fact! This innovative device, first launched over a decade ago with the nVista system, miniaturizes the bulky bench-top fluorescence microscope into a 2-gram tool that can be mounted onto the skull of a living animal to observe its brain activity. 𝗪𝗵𝗮𝘁 𝗶𝘀 𝘁𝗵𝗲 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗕𝗲𝗵𝗶𝗻𝗱 𝗠𝗶𝗻𝗶𝘀𝗰𝗼𝗽𝗲 𝗜𝗺𝗮𝗴𝗶𝗻𝗴? Calcium imaging is key, allowing researchers to visualize neural activity in real-time. When neurons are active, calcium ions flow into the cells, using fluorescent protein indicators that emit a signal upon binding calcium, thus capturing the intensity of neural activity. This technique reveals how neural circuits operate in real-world conditions. 𝗛𝗼𝘄 𝗱𝗼𝗲𝘀 𝗶𝘁 𝘄𝗼𝗿𝗸? 🧠 𝗦𝗶𝗴𝗻𝗮𝗹 𝗖𝗮𝗽𝘁𝘂𝗿𝗲: Inscopix miniscopes detect fluorescent signals using GRIN (Gradient Refractive Index) lenses or cranial windows, enabling the observation of thousands of neurons during cognitive or behavioral tasks. 🐁 𝗔𝗰𝘁𝗶𝘃𝗶𝘁𝘆 𝗥𝗲𝗰𝗼𝗿𝗱𝗶𝗻𝗴: As animals engage in active, freely-moving behaviors, the miniscope records neuronal activity. 💻 𝗗𝗮𝘁𝗮 𝗧𝗿𝗮𝗻𝘀𝗺𝗶𝘀𝘀𝗶𝗼𝗻: The imaging, optogenetic, and behavioral data are seamlessly transferred to an Inscopix Data Acquisition (DAQ) box, and the images and behavior movies are streamed live to a computer or mobile device. 🔎 𝗗𝗮𝘁𝗮 𝗣𝗿𝗼𝗰𝗲𝘀𝘀𝗶𝗻𝗴: This data is then processed with IDPS (Inscopix Data Processing Software) and IDEAS (Inscopix Data Exploration, Analysis, and Sharing) platforms to infer deeper insights into the patterns of neuronal activity and their correlation with behavior. Whether it is understanding behavior, decoding cognitive processes, or advancing disease research, Inscopix and their full suite of miniscope imaging technologies (nVue, nVoke, and nVista) have been at the forefront of basic neuroscience discovery and translational applications. ▶️ https://lnkd.in/dZQ8AFGg #neuroscience #DiseaseResearch #optogenetics #microscopy #lifesciences

🔬 𝗠𝗶𝗰𝗿𝗼𝘀𝗰𝗼𝗽𝘆 𝗠𝗼𝗻𝗱𝗮𝘆 🔬 Maximum intensity projection with depth color coding of dendrites and spines in a brain slice. Image taken on the Ultima Investigator Plus. #MicroscopyMonday #neuroscience #lifesciences