The Jackson Laboratory

The Jackson Laboratory team is heading to the Protein and Antibody Engineering Summit (PEGS Europe) in Barcelona, Spain from November 5-7. JAX will be sharing how immune humanized mouse models enable better fine-tuning of your biologic candidates for enhanced efficacy and reduced toxicity. Let’s connect and discuss what ‘better’ actually means - learn more: https://bit.ly/3NMXiwg #PEGSEurope

A recent study published in Science Magazine discovered that a surge in duplication of the amylase gene during human evolution shaped our adaptation to starchy foods and may have occurred more than 800,000 years ago, long before the advent of farming. Read more in this article from CNN's Katie Hunt featuring first author Feyza Yilmaz, PhD, an associate computational scientist at JAX: https://lnkd.in/eDP9kAkS

Elise Courtois, JAX Director of Single Cell Biology Lab and EndoRISE co-director, participated in a panel at Cal State LA following the screening of an EndoWhat? production, "Below the Belt." The patient-led panel, translated live into Spanish, brought the Los Angeles community and endometriosis experts together to discuss education, share support, and empower those affected by endometriosis. Thank you again to our co-hosts Chism-Endo and California State University, Los Angeles.

A key player in providing individualized medicines to patients is industry partners. The N=1 Collaborative Inaugural Annual Meeting 2024 Industry Panel featured Nianwei Lin of iXCells Biotechnologies, David Butler of Hongene Biotech Corporation, Rebecca Miles of ReiNA Consulting, Cat Lutz of The Jackson Laboratory, and Jeremy Little of ChemGenes. Panelists discussed how n-of-1 treatments differ from traditional therapy development in terms of process, scale, and methods. They also identified what they believe is the biggest bottleneck for scaling up and ensuring sustainability in the development of n-of-1 oligonucleotide drugs. Thank you to our industry partners for problem-solving with us to bring individualized therapies to patients in their lifetime. Nianwei Lin David Butler Rebecca Miles Cat Lutz Jeremy Little, Jillian Belgrad, Stefanie Leonard, MSN, RN, Geri Beaty, Annemieke Aartsma-Rus, Nicole Nolen, Erin M. McConnell, Ph.D., Winston Yan, MD PhD, Tim Yu, Julia Vitarello, Hugh Hempel, Holm Graessner, Nicole Boice, Nina Green, Ashley Kuniholm, Margaret Meserve, MS, CGC, Erika Fullwood Augustine, Scott Demarest, Richard Finkel, MD, John Keilty, Marlen Lauffer, Rebecca Schüle, Jonathan Watts, Melody Joy Paine

JAX professor Jeffrey Chuang's recently published study in Communications Biology reveals never-before-seen details of the interactions of cancer cells and their surrounding cells. “Researchers have long suspected that better characterizing this complex community, which includes immune cells, blood vessels, and signaling molecules, could shed light on how cancers grow, spread, and respond to treatment,” said Chuang. "This new analysis lets us quantify the locations and interactions of cells and molecules in a way that has never before been possible using imaging.” Read more: https://lnkd.in/e2RibDzc

JAX professor Gary Churchill, Ph.D. recently spoke with Nick Jikomes, Ph.D on the Mind & Matter Podcast 🧠 about his study published in Nature which explores using the power of genetic diversity in mice to uncover new details about the relationship between diet and longevity. 🎧 👀 Watch & listen to the full episode: https://lnkd.in/eciqpdEv 📖 Read more: https://lnkd.in/ejse86xD

During remarks at a recent New England Council Capitol Hill Report meeting, U.S. Senator Susan Collins recognized The Jackson Laboratory for its work on Alzheimer’s disease research. We are grateful to Senator Collins for her support of our research. JAX scientists are working to improve AD research and open new areas of exploration and discovery. Read more about their latest findings and the work of The Model Organism Development and Evaluation for Late-onset Alzheimer’s Disease (MODEL-AD) Consortium, a multi-institution collaboration established to create and distribute effective mouse models for AD: https://bit.ly/3NIghIm Pictured L-R: JAX Vice President of External and Government Affairs LuAnn Ballesteros, Senator Collins

Today, we remember the tragic events of October 25, 2023, in Lewiston, Maine. Our hearts remain with the families and loved ones of the victims, and we are honored to be part of Maine’s resilient and special community.

JAX researchers Michael Stitzel, Ph.D., and Duygu Ucar, PhD discovered that DNA sequence changes known to increase a person’s risk for diabetes are linked to how well pancreatic cells can handle stress, including inflammation and high blood pressure. Learn more ➡️ the study was published in Cell Metabolism and featured here in Genetic Engineering & Biotechnology News: https://lnkd.in/euVur7Mt

In a new Nature study, a team of researchers at YSM, The Jackson Laboratory, and the Broad Institute of MIT and Harvard use generative #AI to create #DNA sequences never seen in nature. The synthetic sequences, or cis-regulatory elements, can selectively turn #genes “on” and “off” in targeted cell types. https://brnw.ch/21wO2Gq