The David and Lucile Packard Foundation

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 Nobel Prize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”   The Nobel Prize in Chemistry 2024 is about proteins, life’s ingenious chemical tools. David Baker has succeeded with the almost impossible feat of building entirely new kinds of proteins. Demis Hassabis and John Jumper have developed an AI model to solve a 50-year-old problem: predicting proteins’ complex structures. These discoveries hold enormous potential.   The diversity of life testifies to proteins’ amazing capacity as chemical tools. They control and drive all the chemical reactions that together are the basis of life. Proteins also function as hormones, signal substances, antibodies and the building blocks of different tissues.   Proteins generally consist of 20 different amino acids, which can be described as life’s building blocks. In 2003, David Baker succeeded in using these blocks to design a new protein that was unlike any other protein. Since then, his research group has produced one imaginative protein creation after another, including proteins that can be used as pharmaceuticals, vaccines, nanomaterials and tiny sensors.   The second discovery concerns the prediction of protein structures. In proteins, amino acids are linked together in long strings that fold up to make a three-dimensional structure, which is decisive for the protein’s function. Since the 1970s, researchers had tried to predict protein structures from amino acid sequences, but this was notoriously difficult. However, four years ago, there was a stunning breakthrough.   In 2020, Demis Hassabis and John Jumper presented an AI model called AlphaFold2. With its help, they have been able to predict the structure of virtually all the 200 million proteins that researchers have identified. Since their breakthrough, AlphaFold2 has been used by more than two million people from 190 countries. Among a myriad of scientific applications, researchers can now better understand antibiotic resistance and create images of enzymes that can decompose plastic.   Life could not exist without proteins. That we can now predict protein structures and design our own proteins confers the greatest benefit to humankind. Learn more Press release: https://bit.ly/3TM8oVs Popular information: https://bit.ly/3XYHZGp Advanced information: https://bit.ly/4ewMBta

New MBARI research reveals the dynamic processes that sculpt the Arctic seafloor. MBARI researchers—working alongside a team of international collaborators from the Korea Polar Research Institute, the Korea Institute of Geoscience and Mineral Resources, the Geological Survey of Canada, and the U.S. Naval Research Laboratory—have discovered large underwater ice formations at the edge of the Canadian Beaufort Sea, located in a remote region of the Arctic. The recently discovered layers of ice are not the same as the ancient permafrost formed during the last ice age, but rather were created under present-day conditions. This ice is produced when deeper layers of ancient submarine permafrost melt, creating brackish groundwater that rises and refreezes as it approaches the colder seafloor. This discovery reveals an unanticipated mechanism for the ongoing formation of submarine permafrost ice. The complex morphology of the seafloor in this region of the Arctic tells a story that involves both the melting of ancient permafrost that was submerged beneath the sea long ago and the disfiguration of the modern seafloor that occurs when released water refreezes. Learn more: https://lnkd.in/gTT5SHs8

📣The GAAP Fellowship application is now open. GAAP is a cohort-based fellowship program for artist advocates, 18 years or older, who live or work in Oakland or San Francisco. Artist Advocates include diverse artists, culture bearers, and creative workers with a dedicated and committed artistic or cultural practice who directly engage in advocacy and policy development to advance the holistic well-being of the field. Each artist advocate will identify a change they want to make happen and be supported to develop an advocacy plan to enact that change. ☑️Join us for an informational webinar on Friday, October 4 at 12:00 PM to gain an in-depth understanding of the program and ask any questions you have about GAAP and the application process! ☑️Applications will open from October 1-14, 2024. Learn more: https://lnkd.in/g5VHNm8f ⁠ GAAP is funded by The Kenneth Rainin Foundation.⁠ ⁠ #artists #artsadvocacy #bayareaartists #CAisCreative #InvestCAArts #CreativeEconomy #culturebearers #culturalworkers #creativeworkers #artsworkers