Standard BioTools

When exhaustion sets in, pushing through to finish the job can be tough. This couldn’t be more true than for T cells working to destroy a tumor… T cell exhaustion is well documented in all kinds of diseases, and is an integral part of the cancer-fighting process that we are only beginning to fully understand – a process that immunotherapy, particularly immune checkpoint blockades, aims to help modulate. But with little understanding of the mechanisms of resistance or response to immunotherapy, designing new immunotherapies and effectively using existing ones is a challenge the cancer community is trying to address. Let’s take a deeper look into T cell exhaustion as it applies to cancer: https://lnkd.in/gT9ziTxq The ability to image T cell exhaustion now accelerates this type of research, allowing a view of what’s actually happening with these cells in the context of their environment – learn how: https://lnkd.in/g_NWvP28 #immunotherapies #breastcancer #cancerresearch #scienceblog #Tcellpanel

Special seminar announcement at the 53rd Annual Meeting of the Japanese Society for Immunology on December 4: Hiroshi Kagamu, MD, PhD, Professor, Saitama Medical University International Medical Center, will be presenting new findings into the behavior of specific T cell subsets, such as precursor exhausted CD8+ T cells (Tpex), upon immune checkpoint inhibitor treatment and how they are generating a lasting antitumor response. The session will be moderated by Atsushi Kumanogoh, MD, PhD, Professor of Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University.

Understanding different cell types and capturing rare cell types associated with Alzheimer’s Disease in a spatial context allows us to learn about the pathological processes involved and how we can leverage those to help Alzheimer’s patients. Standard BioTools is facilitating and accelerating this process with the capability to simultaneously detect key protein targets with a pre-validated neuro-phenotyping panel containing 31 antibodies, plus the easy addition of the Alzheimer’s disease panel that identifies amyloid aggregates and Tau tangles. Take a look through imaging examples to see how these new panels can help us see the disease more clearly: https://lnkd.in/giECekUW #spatialbiology #neuroscience

New work from researchers at Sun Yat-sen University Cancer Center, Guangzhou, aims to improve cancer patient selection for immunotherapy using novel predictive biomarkers, addressing the limited response rate of immune checkpoint inhibitors for patients with solid tumors. The team profiled a dynamic single-cell atlas using CyTOF technology from 12 pairs of matched relapsing and non-relapsing patients with nasopharyngeal carcinoma and determined that the Ki67+ Treg subset strongly correlated with treatment outcome, demonstrating high predictive value for immunotherapy response. CyTOF immune profiling enables detailed analysis of multiple cell populations from one sample. “CyTOF [is] powerful for immunophenotyping to identify prognostic or predictive immune biomarkers in cancer clinical trials where samples are rare and limited.” Huang et al. Signal Transduction and Targeted Therapy 2024: https://lnkd.in/gwhSz5XV #personalizedmedicine #carcinoma #immunotherapies

Why attend the upcoming cytometry #masterclass with Connie Chao Inlay, PhD? ❇️ Discover how to analyze cytokine activity and immune checkpoint expression effectively ❇️ Overcome technical challenges in building large parameter panels ❇️ Learn how to combine modular panels for application-specific immunophenotyping and functional evaluation of human oncology samples Sign up now: https://lnkd.in/gfQW5-ZK #cytometry #immuneprofiling #cellfunction

Check out what’s happening at the EMBO Workshop… With an industry symposium and associated poster sessions, learn how you can use different imaging modes on the same slide to get different perspectives into spatial architecture and cellular diversity within a tumor microenvironment. Sometimes a 5-minute whole slide overview is all you need to see how different niches interact. Or go in-depth with high-resolution regions of interest to learn what’s happening at the subcellular level. Learn more about the technology used in the incredible research shared by Raza Ali, PhD, on charting the intact breast tumor microenvironment for personalized oncology. Join Roberto Spada and Paolo Santino in Rome at Booth 6 and at their upcoming presentations using Imaging Mass Cytometry™ to unlock new views. More on the event: https://lnkd.in/dceZgfQv More on IMC™: https://lnkd.in/gemztxuy

Planning on #ASHG24 in Denver? Then definitely plan on these industry sessions while you are there! Think of the possibilities and what you might find by looking at 11,000 protein targets in one shot. No need to bridge studies with this high level of coverage, enabling comprehensive association studies for a better understanding of the molecular relationships between genes and proteins responsible for health and disease. Learn more: https://lnkd.in/dYaFKaGz Then imagine one workflow that can detect both SNPs and CNVs in a single run on the same plate. Pharmacogenomics studies can be complicated, but they don’t have to be. One workflow can do it all with comprehensive and actionable genetic coverage. Talk with us! Visit Booths 145 and 1188 to see the newest Standard BioTools products in person… 

Interested in the pivotal role that biocontrol plays in ensuring productive farming? The 19th Annual Biocontrol Industry Meeting (ABIM) 2024 is in Basel to address key challenges faced by farmers, discuss the regulation of biocontrol and network with industry peers. Learn about genomics that scales anytime, anywhere… The Biomark™ X9 platform is the only walkaway automated PCR, qPCR and NGS library prep benchtop system, capable of running genomics assays with robustness, speed and precision in even the most extreme environments. Thank you to Beate Schurek and Michel Perriere! #ABIM2024: https://www.abim.ch/

Join the discussion with James Pemberton, PhD, on rapid multiplex imaging and its pivotal role in advancing spatial biology. This seminar will demonstrate how the multi-modal features of Hyperion™ XTi, combined with advanced analysis tools from Visiopharm, are transforming our understanding of tissue organization in health and disease.

🚨October 30, 10am SGT🚨 Join Helen McGuire PhD, Senior Lecturer at the University of Sydney, as she shares a cutting-edge approach to immune monitoring in multi-site clinical trials—simplifying sample collection and benefiting remote and underrepresented populations. 🔬 Discover a novel immune signature that predicts non-responsiveness to checkpoint therapies, offering a powerful tool for treatment decisions. 🧬 Explore how the SomaScan® Platform, with 11,000 protein measurements, tracks disease progression and immune response in real time. 📊 Learn how combining cellular and plasma data can improve clinical outcome prediction, incorporating multi-omic data integration into your research. Registration is free: https://lnkd.in/gEvvZXmM