4Dcell’s Post

📢 Abstract submission deadline approaching on 28 November. Sign up for the EMBO Workshop 'The new cardiobiology' and deepen your understanding of the causes and early development of cardiovascular disease 🫀 📩 Submit abstract by 28 November 📍 EMBL Heidelberg and Virtual ➡️ s.embl.org/ncb24-01 New tissue engineering and mechanobiology approaches are revolutionising cardiovascular discovery research and disease modeling by more closely mimicking the human situation. The #EMBOCardioBiology conference aims to transform the established organ-centric view on single cardiovascular organs into a systems biomedicine approach by tearing down the walls between disciplines and moving on to discussion of the cardiovascular system with an inter-, trans-, and cross-disciplinary approach. #EMBLHeidelberg #EMBOWorkshop #EMBL #cellarchitecture #tissuearchitecture #cardiovascular #cardiovasculardisease #molecularmedicine #cardiovascularresearch #signaltransduction #cellularmetabolism #cardiovascularhealth #cardiacdifferentiation #cardiactissueengineering #organoids #myocyte

#NEXTWEEK | Dr. Melanie White presents the various methods for assessing cardiac function in the context of pathology, spanning from in vitro to in vivo techniques + more! Engage with a true expert and gain insights that could revolutionize your research! REGISTER HERE: 👉 https://lnkd.in/gSuJuD5Q 👈 🔍 Key Topics Include: ✅ Method considerations to address different biological questions ✅ Tips and tricks for improving success using ex vivo cardiac perfusion ✅ The downstream implications for the various approaches to basic cardiac functional studies #ADInstruments #MakingScienceEasier #CardiacResearch

🔖 Excited to share a new blog post on improving model interpretability and reliability through biomarkers in the field of medicine. Our research investigates the use of biomarker-based lung ultrasound diagnostic pipeline to enhance diagnostic capabilities. Learn how decision tree explanations utilizing clinically established biomarkers can assist clinicians in detecting false positives, thus improving model reliability. Read the full post at https://bit.ly/3I7dndf

Excited about the upcoming EBMO Cardiobiology conference! Looking forward to meeting some of you there. Let's connect and dive into discussions on the latest developments in the field. #EBMOCardiobiology #Networking

We hope you found our recent seminars on live cell imaging in research intriguing. Curiosis recently concluded two successful events, focusing on these cutting-edge topics and showcasing our advanced Celloger® system. These seminars emphasized the critical role of real-time cell observation in deciphering disease mechanisms and pioneering new therapies. We look forward to your continued interest in our future events as we move forward. Stay tuned for updates on upcoming opportunities to explore even more innovative solutions! #Curiosis #Seminar #LifeScience #CellBiology #CellResearch #Research #LiveCellImaging #Celloger #Applications

🌟 Unlock the Future of Liver Therapies! 🌿 This latest protocol by Saloni Sinha, Duc-Huy Nguyen, Nora Hassan, Qazi Ali,Jason Sethiadi, Sergey Tsoy, and Robert Schwartz at Weill Cornell Medicine unveils a step-by-step guide for in vivo hepatocyte implantation, enhancing the landscape of tissue engineering and regenerative medicine. https://lnkd.in/gncZM7i9 🔬 Key Features: 🔹 Primary human hepatocytes with firefly luciferase for enhanced functionality. 🔹 Mesenteric parametrial fat pad in female nude mice offers an ideal microenvironment. 🔹 Bioluminescence imaging for real-time tracking of hepatocyte survival. Bio-protocol sincerely thanks Pilar Villacampa Alcubierre, Aras Mattis, MD, PhD, and William C. W. Chen for reviewing the work. #LiverTherapies #TissueEngineering #RegenerativeMedicine Do you have a protocol that can contribute to scientific clarity and reproducibility ? Visit us at https://lnkd.in/dt_igxRi and explore publishing with Bio-protocol at https://lnkd.in/dJrqztsf! #openaccess #reproducibility #lifesciences #research #bio

Wake Forest University School of Medicine Dr. David Caudell, DVM's research hits new heights with two recent high-impact publications! First, published in #PNAS [https://lnkd.in/gTW3pp23] demonstrates the activity of fibroblast stimulating lipopeptide (FSL-1) as a countermeasure agent against hematopoietic acute radiation syndrome. #hematopoiesis, #innateimmunity, #radiation And, the second most recent paper made the cover of the #JLB (Journal of Leukocyte Biology)! The work establishes the #CD40 agonist selicrelumab as safe and effective at stimulating a systemic immune response when administered via subcutaneous injection, supporting its use in humans. #immunotherapy In the words of our colleague Dr. Mark Cline, DVM: "The paper represents an enormous collaborative effort with an international team, encompassing a decade of hard work and detailed exploration of unexpected findings (the best kind of results!)." Congratulations Dr. Caudell and team! #WakeMedExcellence

𝗖𝗮𝗻 𝗻𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀 𝗻𝗲𝘂𝘁𝗿𝗮𝗹𝗶𝘇𝗲 𝘀𝗻𝗮𝗸𝗲𝗯𝗶𝘁𝗲 𝘃𝗲𝗻𝗼𝗺? Learn more and read the paper here: https://lnkd.in/dWc8FpsW In this 7th paper together, DTU - Technical University of Denmark and Sophion Bioscience have published on nanobodies (the part of an antibody that binds to specific peptides) that can bind and neutralize the key active components found in coral snake venom. Dr. Melisa Benard Valle, PhD & colleagues in professor Andreas Laustsen-Kiel’s lab used a variety of antibody/nanobody discovery techniques to find an oligoclonal mix to bind and neutralize a variety of venom peptide components. Via the Qube 384 nAChR channel recordings, Sophion’s Dr. Kim Boddum showed the venom alpha-neurotoxin neutralizing capacity of these nanobodies. Finally, professor Alejandro Alagon’s lab at Instituto de Biotecnología UNAM showed these nanobodies increased mouse survival rates in envenomation studies. Congratulations to all authors on this Nature Communications paper that takes us another step closer to finding treatments for snakebite, a World Health Organization designated neglected tropical disease. #Toxins #Venom #PhageDisplay #AntiBody #Qube384 #AutomatedPatchClamp #IonChannels #DrugDiscovery #Electrophysiology #Sophion

Can humanized mice help reduce, refine, and replace the use of non-human primates in preclinical development? Join Dr. Kaya Ghosh and Dr. Aaron Rose from The Jackson Laboratory as they unveil how humanized mouse models are revolutionizing drug research. Learn how these models effectively replicate human physiology and enhance drug development by predicting responses to immunomodulatory compounds. Register here: https://lnkd.in/gVcZCTsD #preclinicalresearch #drugdevelopment #humanizedmice