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Activated PI3Kδ syndrome (#APDS) is a rare immune disorder with significant unmet needs, including misdiagnosis and delayed diagnosis. In Spain, a multidisciplinary committee evaluated APDS treatment using multicriteria decision analysis (#MCDA). Current treatments are mainly off-label and provide limited disease control, with haematopoietic stem cell transplantation being the only potential curative option but with restricted use. The study highlights APDS's high economic burden and suggests MCDA as a valuable tool for enhancing clinical and decision-making processes.| https://ow.ly/rOes50SgXrI

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