Oncology and Cancer Research Group Journals’ Post

https://lnkd.in/eyKVpJwB Article title: The probably use of MR-spectroscopy and diffusion weighted-MRI of bone marrow for treatment monitoring in patients with chronic lymphatic leukemia   Author(s): Vicente Martínez-Vega; Mar Jiménez-Peña; Javier Carrascoso-Arranz; Margarita Rubio-Alonso; Juan Bachiller-Egea; Carmen Martínez-Chamorro ; Manuel Recio-Rodríguez Journal: Annals of Bone Marrow Research   Journal ISSN: 2692-4684 Abstract: To assess the usefulness of proton MR-spectroscopy (1H-MRS) and diffusion-weighted MRI (DW-MRI) sequences in the follow-up of CLL-patients with chemotherapy treatment. The monitoring of CLL-patients susceptible to chemotherapy treatment is complicated due to the difficulty in assessing the response to treatment. Chemotherapy leads to changes in bone marrow composition and these changes can be evaluated by functional MR-sequences. #Chroniclymphaticleukemia #1HMRS #Bonemarrowspectroscopy #DiffusionMRI #Bonemarrowinfiltration   #BoneMarrow #BloodSamples #Hematology #AutoimmuneDiseases #StemCells #Immunology #Transplantation #MinimalInvasiveSurgeryTechniques #TranscriptionFactors #Medication #TropicalTreatments #Metabolism #Mortality #DrugTargeting #DrugSensitivity #Resistance #HabitsAndLifestyle #PrognosticFactors #Pathophysiology #NovelDrugs #CellularTherapy #TranslationalResearch #MesenchymalStemCell #HematopoieticStemCellTransplantation #BoneMarrowTransplantation #BoneMarrowEdema #BoneMarrowCancer #BoneMarrowBarrier

Early diagnosis by GP/family doctor is crucial to improving patient clinical outcomes. In the interview, Dr. Giovanni Marconi, Hematologist and Researcher at the University of Bologna, explains the critical phases for achieving an early diagnosis of leukemia, where the GP/family doctor plays a fundamental role in detecting the disease and correctly referring the patient to a specialist. #Alan #WLD24 #worldleukemiaday2024 #DrMarconi #Hematology #interview #Doctors #FamilyDoctor #GPs #GP #patients #diagnosis #disease #leukaemia #leukemia  

https://lnkd.in/gn_msagj Article title: Myeloproliferative Neoplasms: Fatigue, depression & hemoglobin   Author(s): Marina Stal*   Journal: Archives of Hematology Case Reports and Reviews   Journal ISSN: 2640-7914 Abstract: Objective: To evaluate existing relationships and differences in fatigue, depression, and hemoglobin value in individuals with Myeloproliferative Neoplasms. Methods: This study utilized the Fatigue Severity Scale, Beck Depression Inventory-II, and self-report of MPN diagnosis and latest hemoglobin value to assess the dependent variables. To promote optimal opportunity for participation in this study, potential subjects were recruited through three online-based disease-specific support groups. A total of 125 individuals consented to participate in the study. #HealthPsychology #Cancer #Fatigue #PsychoOncology #QualityOfLife #Anemia #AcuteMyeloidLeukemia #LymphAngiogenesis #HematologicalMalignancies #BloodTransfusion #SerumProteinElectrophoresis #HematopoieticStemCellTransplantation #PhotoAcoustics #LymphNodeBiopsy #BCellLymphoma #InvivoFlowCytometry #ChainsofHemoglobin #Lymphoma #HodgkinsLymphoma #Coagulation #Thalassemia #NonHodgkinsDisease #MultipleMyeloma #StemCellsAndHematopoiesis #LeukocytesAndPlatelets #RedCellBiology #HematologicNeoplasia #Immunobiology #BloodAndMarrowTransplantation #TransfusionMedicine #VascularBiology #Hemobiology #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers

Activated PI3Kδ syndrome (#APDS) is a rare immune disorder with significant unmet needs, including misdiagnosis and delayed diagnosis. In Spain, a multidisciplinary committee evaluated APDS treatment using multicriteria decision analysis (#MCDA). Current treatments are mainly off-label and provide limited disease control, with haematopoietic stem cell transplantation being the only potential curative option but with restricted use. The study highlights APDS's high economic burden and suggests MCDA as a valuable tool for enhancing clinical and decision-making processes.| https://ow.ly/rOes50SgXrI

https://lnkd.in/g4a5ZbFZ Article title: A Patient Diagnosed with POEMS Syndrome with Atypical Presentation   Author(s): Seyin Semiz H*; Sarıkaya O; Duran M; Ozsan N; Saydam G   Journal: Archives of Hematology Case Reports and Reviews   Journal ISSN: 2640-7914 Introduction: POEMS syndrome is a paraneoplastic syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyradiculoneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease. Minor features include organomegaly, endocrinopathy, characteristic skin changes, papilledema, extravascular volume overload, and thrombocytosis [1]. Autologous Stem Cell Transplantation (ASCT) might be potential approach of choice in patients that are eligible; otherwise, systemic therapies adopted from the therapeutic armamentarium for multiple myeloma are alternatives [2]. İn this paper, we reported that a patient which was treated with VAD (Vincristine, Doxorubicin, Dexamethasone 40 mg) with exlusion of vincristine due to existing neuropathy and ASCT with high-dose melphalan and improved; although the bone marrow biopsy did not observe a plasma cell clone. #Anemia #AcuteMyeloidLeukemia #LymphAngiogenesis #HematologicalMalignancies #BloodTransfusion #SerumProteinElectrophoresis #HematopoieticStemCellTransplantation #PhotoAcoustics #LymphNodeBiopsy #BCellLymphoma #InvivoFlowCytometry #ChainsofHemoglobin #Lymphoma #HodgkinsLymphoma #Coagulation #Thalassemia #NonHodgkinsDisease #MultipleMyeloma #StemCellsAndHematopoiesis #LeukocytesAndPlatelets #RedCellBiology #HematologicNeoplasia #Immunobiology #BloodAndMarrowTransplantation #TransfusionMedicine #VascularBiology #Hemobiology #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers

Fine needle aspiration (FNA) is a minimally invasive medical procedure used to collect a sample of cells or fluid from a suspicious lump or area in the body. The sample is then examined under a microscope to help diagnose various conditions, including cancer. FNA is performed for several reasons: Diagnosis of cancer: FNA is commonly used to determine whether a lump or mass is cancerous or benign (non-cancerous). It can be used on various parts of the body, such as the breast, thyroid, lymph nodes, and soft tissues. Evaluation of abnormal cells: Even if a lump is not suspected to be cancerous, FNA can help identify the cause of abnormal cells or inflammation. This can be useful in diagnosing infections or other non-cancerous conditions. Guiding treatment decisions: In cases where cancer is already diagnosed, FNA can help determine the specific type of cancer and its characteristics. This information is crucial for selecting the most appropriate treatment options. Monitoring response to treatment: FNA can also be used to assess how well a cancer is responding to treatment by monitoring changes in the cells over time. . . . Meet Dr. Hitendra K. Garg, DM (GASTROENTEROLOGY), MD(MEDICINE) Senior Consultant - Hepatology, Gastroenterology & Liver Transplant . . . Schedule a consultation at Indraprastha Apollo Hospitals  Visit: www.drhitendrakgarg.com For Consultation : Dr. Hitendra K Garg 📲 8920361841, 8920632657  . . . #Gastroenterologist #drhitendragarg #bestgastroenterologistindelhi #FineNeedleAspiratio #FNAProcedur #HealthAwareness #CancerDetection #NonInvasiveProcedure #MedicalTests #Healthcare #Pathology #MedicalScience #EmpowerYourHealth #FNAChallenge #KnowYourBody #CancerScreening #QuickDiagnosis #NoCutsNoScars #HealthcareHero #MedicalMythBusters #ScienceSavedMyLife #health 

Cool paper in Developmental Cell: Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts https://lnkd.in/eb65z6Xk Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, highly heterogeneous neurodegenerative disease, underscoring the importance of obtaining information to personalize clinical decisions quickly after diagnosis. Here, we investigated whether ALS-relevant signatures can be detected directly from biopsied patient fibroblasts. We profiled familial ALS (fALS) fibroblasts, representing a range of mutations in the fused in sarcoma (FUS) gene and ages of onset. To differentiate FUS fALS and healthy control fibroblasts, machine-learning classifiers were trained separately on high-content imaging and transcriptional profiles. “Molecular ALS phenotype” scores, derived from these classifiers, captured a spectrum from disease to health. Interestingly, these scores negatively correlated with age of onset, identified several pre-symptomatic individuals and sporadic ALS (sALS) patients with FUS-like fibroblasts, and quantified “movement” of FUS fALS and “FUS-like” sALS toward health upon FUS ASO treatment. Taken together, these findings provide evidence that non-neuronal patient fibroblasts can be used for rapid, personalized assessment in ALS.

💜 Community Talks: Karina 💜 💥 When diagnosis don't justify all symptoms “Daniel had 4 brain surgeries after his diagnosis of Moyamoya in 2001. He was having blood clots and we were advised to have the revascularization surgery so the brain could get better blood flow. Back then, the neurosurgeon who operated on Daniel said to us that Daniel’s MRI didn’t show a typical Moyamoya image. We had to wait 6-7 years to finally get the diagnosis of Multisystemic Smooth Muscle Dysfunction Syndrome (MSMDS). I felt relief with MSMDS including all of Daniel’s symptoms that Moyamoya couldn’t explain. Daniel was one of the firsts to be diagnosed with MSMDS and at that time not much was known about the disease. But it gave me reassurance that the doctors could now keep a close eye on Daniel and compare the results with other patients they could have so all of us together could gain greater knowledge in this disease.” 🧠 MSMDS or Moyamoya? Patients affected by MSMDS with Moyamoya-like disease present a lack of basal collateral vessels and abnormally straight cerebral vessels. Patients with MSMDS have an increased risk of perioperative stroke and usually suffer issues when anaesthesia or sedation are required in medical procedures. 🙌 Understanding MSMDS MSMDS is an incurable multisystemic disease affecting the brain, blood vessels, heart, aorta, lungs, liver, kidneys, bladder, eyes, and other body parts with smooth muscle cells. There are only 60 diagnosed patients worldwide, mostly children. 💚 The Hope of Gene Therapy Gene therapy research in Boston offers hope for MSMDS patients. With your support, we can bring life-changing treatments to those affected by this ultra-rare disease. https://lnkd.in/edkSR9Cy #ActByAct #MSMDS #GeneTherapy #MSMDSAwarenessDay #PatientStory #RareDiseaseAwareness #Moyamoya #moyamoyadisease #MoyamoyaAwareness #Revascularization #brainsurgery #brainsurgerysurvivor #genetherapy

Stem cell therapy has emerged as a promising and innovative approach in the treatment of liver diseases, offering the potential to regenerate damaged liver tissue and restore organ function. Liver diseases, such as cirrhosis or chronic hepatitis, often result in significant damage to the liver, impairing its ability to heal naturally. Stem cells, with their unique ability to differentiate into various cell types, including liver cells, can be harnessed to replenish the damaged tissue. By introducing these cells into the liver, they can promote tissue repair, reduce inflammation, and stimulate the regeneration of healthy liver cells. This therapeutic approach not only addresses the symptoms but also targets the underlying causes of liver diseases. #health #liverdisease #liverhealth #stemcells #stemcelltherapy

NEJM Editor-in-Chief Eric J. Rubin, M.D., Ph.D., previews the Notable Articles of 2023, a collection of article abstracts, Research Summaries, and accompanying Editorials from the selected studies. Featured studies include: 🧬 Base-Edited CAR7 T Cells for Relapsed T-Cell Acute Lymphoblastic Leukemia 🌐 Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants 🧠 Lecanemab in Early Alzheimer's Disease 🩸 Randomized Trial of Early Detection and Treatment of Postpartum Hemorrhage Trial 💊 Treatment Strategy for Rifampin-Susceptible Tuberculosis 🎉 Bonus notable articles from NEJM Catalyst Innovations in Care Delivery, NEJM Evidence, and the new NEJM Group journal, NEJM AI Download the 13 articles NEJM editors selected as the most meaningful in changing clinical practice and improving patient care in 2023: https://nej.md/notable2023 #MedicalResearch