Actylis Lab Solutions’ Post

Are you curious about how our dicopper hydride complex can catalyze the dehydrogenation of formic acid? Check out my #RSCPoster! #RSCCat #RSCInorg We combined detailed kinetic studies with coordination chemistry and even structurally characterized the resting state of the catalyst to understand the mechanism of this rare reaction. Please feel free to reach out to me if you have any questions or if you would like to discuss the work! A preprint of this work is also available on ChemRxiv (DOI: 10.26434/chemrxiv-2024-cg4fk)

Our total synthesis of lappaceolides A and B is now on ChemRXiv as a preprint (https://lnkd.in/eT7fvtDa). A biomimetic vinylogous-Michael–oxa-Michael domino dimerization reaction constructs both the natural products in a single step from siphonodin! While it looks simple when you see it written out, the domino reaction required intense optimization to arrive at the said reaction conditions.

🔬 The process of creating a #CertifiedReferenceMaterial is laborious and it usually involves different steps: 🏵️ Cultivation of the #microalgae. 🔎 Isolation and purification of the #toxins of interest. 🧪 Characterization by UPLC-MS/MS and NMR. 📃 Finally, certification to obtain a fully guaranteed product. During our daily routine, we come across new #molecules of interest. We are currently involved in developing new ones, such as doSTX, GC1&2, GC3, GC4&5, GC6, dcGTX1&4, 12-β-deoxySTX, M1, and M3. 👉 https://lnkd.in/dspbf6RC 👈 Ask for our constantly updated catalog! #PSP #MarineToxins #MarineBiotoxins #Standard #CRM #Biotoxins #Saxitosin #Decarbamoylgonyautoxins

At the recent 2024 US #Bioassay Conference (BEBPA), we presented a poster presentation entitled: "Outlier Analysis for Relative Potency Assays Using SoftMax Pro Function for Rosner Extreme Studentized Deviate Test". The poster demonstrates our specific outlier identification approach for dose-response curves in relative potency assays utilizing SoftMax Pro data acquisition and analysis software templates to perform all calculations without having any data transfer to another statistical program. Our approach aligns with the best practices recommended in the field of bioassay potency testing, where outlier screening is crucial to avoid biased relative potency estimates and false acceptance/rejection of samples. Click here to access the poster presentation: https://lnkd.in/gzYrEDJc Poster author: Alena Nikolskaya, Associate Director of Analytical Method Development

Over the last few years, there has been a rapid increase in the demand for oligonucleotides production. Before being used in downstream applications, oligonucleotides must be cleaved from the solid support and have their protecting groups removed. Currently, although the synthesis process is automated and computer controlled, the post-processing steps involving cleavage and deprotection are still carried out manually. To address this challenge, 𝗠𝗶𝗹𝗲𝘀𝘁𝗼𝗻𝗲 𝗵𝗮𝘀 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗲𝗱 𝘄𝗮𝘃𝗲𝗣𝗥𝗘𝗣, an efficient, rapid, and safe tool specifically designed for the post-processing 𝗰𝗹𝗲𝗮𝘃𝗮𝗴𝗲 𝗮𝗻𝗱 𝗱𝗲𝗽𝗿𝗼𝘁𝗲𝗰𝘁𝗶𝗼𝗻 (𝗖&𝗗) steps in oligonucleotide production. The wavePREP process combines cleavage and deprotection into a 𝘀𝗶𝗻𝗴𝗹𝗲 𝘀𝘁𝗲𝗽, eliminating the need for evaporation and ensuring a superior workflow with improved product yields. #waveprep #cleavage #deprotection #oligos #oligonucleotides #postsynthesis

🔬 Unlock the power of 3x faster NMR spectra interpretation with your new digital buddy - ChemisTwin® portal! 📊 In this webinar, learn about our ChemisTwin® platform that automates the NMR analysis, supported by a comprehensive database of digital Reference Materials (dRMs). With ChemisTwin®, you don't just save your precious time but can also ensure safer products with increased sampling rates and spot sample inconsistencies early on. Also, watch it in action with a use-case-based demo. Save your spot now: https://lnkd.in/e-_AJ-ga #pharma #analytics #NMR #automation #digitalization

#AgricultureMdpi – Editor's Choice Article 📍 Nondestructive Testing Model of Tea Polyphenols Based on Hyperspectral Technology Combined with Chemometric Methods by Xiong Luo et al. 👇 Click to read the full article: https://lnkd.in/g2z8cnWh #hyperspectral #teapolyphenols #sampledivision #featureselection #regressionmodel #nondestructivedetection

#AtomicAbsorption is an integral part of both #ClinicalResearch and #PharmaceuticalAnalysis #research #laboratories’ workflows. It detects #ChemicalElements present in a sample through the absorption of characteristic #wavelengths of #ElectromagneticRadiation. But due to the nature of analysis, this method requires solvents that won’t interfere with sample detection and quantification. Our ROMIL PrimAg® and ROMIL-SpA™ ranges are the perfect choice: https://ow.ly/zu1950Ruux2

Today, we kick off a series we are calling "𝗧𝗵𝗲 𝗣𝗿𝗼𝘁𝗲𝗶𝗻 𝗣𝘂𝗿𝗶𝗳𝗶𝗲𝗿: 𝗘𝘅𝗽𝗲𝗿𝘁 𝗜𝗻𝘀𝗶𝗴𝗵𝘁𝘀, 𝗜𝗻𝗯𝗼𝘅 𝗗𝗲𝗹𝗶𝘃𝗲𝗿𝘆". Every Friday for the next 12 weeks, we'll be posting a new technical article that you can read here on LinkedIn or have delivered directly to your inbox 📩 This week's topic: "𝗣𝘂𝗿𝗶𝗳𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗼𝗹𝗶𝗴𝗼𝗻𝘂𝗰𝗹𝗲𝗼𝘁𝗶𝗱𝗲𝘀 𝗯𝘆 𝗮𝗻𝗶𝗼𝗻 𝗲𝘅𝗰𝗵𝗮𝗻𝗴𝗲 𝗰𝗵𝗿𝗼𝗺𝗮𝘁𝗼𝗴𝗿𝗮𝗽𝗵𝘆" Here's a summary of what you'll learn after reading it: 🧬 How anion exchange chromatography can separate the negatively charged oligonucleotides based on length 📈 Strategies for optimizing and scaling-up oligonucleotide purification 🧂 Methods for desalting oligonucleotides after anion exchange chromatography https://lnkd.in/dmXbCcMh Use the above link ☝️ to get a copy delivered to your inbox, and follow us to stay informed when we post the other technical articles in this series.

In this review, summarized the types of PROTAC linkers, the design and optimization strategies used, and the impact of linker characteristics on PROTAC efficacy. The rational design of PROTACs must carefully consider linker characteristics to optimize biodegradation efficiency. Balancing factors such as length, flexibility, stability, hydrophilicity/hydrophobicity, steric properties, and functional groups is essential for developing effective and efficient PROTACs for targeted protein degradation. Last year, there has been a growing number of publications reporting progress in the design and optimization of PROTAC linkers. Enjoy your weekend reading! #PROTAC #linker #DrugDiscovery #Medchemistry https://lnkd.in/ekRD4zH4