Adrian Churchman’s Post

Gain precise insights into the immune system’s response to diseases with autoantibody profiling. Discover the advantages of immunoprofiling in a compelling podcast or get highlights from a quick 3-min read: Podcast: https://lnkd.in/evRnR2ZD Article: https://lnkd.in/eZDscMKA

🔬 Organoids vs. Immortal Cell Lines 🧬 Are you curious about the latest advancements in cell culture technology? In this insightful blog post, CelVivo's Stephen Fey delves into the pros and cons of patient-derived organoids and immortal cell lines. Discover why 3D cultures might be the game-changer we need for more accurate drug testing and personalized medicine. Is it time for a shift in our research paradigms? 📖 Read more: https://lnkd.in/exMnyr7T #BiomedicalResearch #Organoids #CellCulture #Innovation #DrugDevelopment

Out Now! Clinical Operations Spotlight - Edition 02

[Scientific Publication] I'm pleased to share with you our first joint publication with the RECETOX research Institut The fruit of a fruitful collaboration with Pavel Babica team, and in particular with Riju Roy Chowdhury who, during her thesis, spent time in DYMEC2 team at Irset, Institut de recherche en santé, environnement et travail (UMR_S Inserm 1085) Université de Rennes Inserm Grand Ouest, to conduct #research on #Hepoid, a 3D cell culture model of highly differentiated and proliferating human hepatocytes. This approach has enabled us to understand and precise the #toxicity mechanisms of cyanotoxin microcystin LR in #human Thanks to European Digital UniverCity - EDUC for strengthening #research collaborations within European Universities as Université de Rennes and Masaryk University Brno Sébastien LE PICARD Maëlle Flot Sophie Rose Frederic Ezan https://lnkd.in/erp-X_5T

📢 We are excited to present our new collection, "Exploring Novel In Vitro Models for Cystic Fibrosis Research," now open for submissions! 🚀🔬 https://lnkd.in/d75Z3Rkq Cystic fibrosis (CF) is a complex genetic disorder affecting the respiratory and digestive systems, often leading to chronic lung inflammation and pathogen infections. Current animal models face limitations in replicating CF's human complexities, highlighting the need for innovative in vitro approaches. With the recent approval of the “FDA Modernization ACT 2.0,” the use of complex in vitro cultures for drug testing is now a reality, offering more accurate research alternatives. This collection, led by Dr. Roberto Plebani, Dr. Yuncheng M. and, Dr. Domenico Mattoscio, welcomes articles focusing on novel in vitro models for CF research, with a particular interest in papers exploring 3D in vitro models, like organoids and organ-on-a-chip technology, which can enhance drug delivery predictions and provide insights into inflammation dynamics. 📃 Register your interest here: https://lnkd.in/di2q-s58 Manuscript Submission Deadline: 31 January 2025 #CysticFibrosis #CFResearch #InVitroModels #Organoids #OrganOnAChip #DrugDiscovery #Pharmacology #Research #InnovativeScience

Want to know more about Brain-Organoid-on-chip and NETRI’s irrigation technology? Join our webinar next week! #organonchip #brain #skin

Take a glance at the future of 3D cell culture (organoids/3D recustructured epitheliums/explants), innverated and irrigated, without pumps and compatible with automation. Just join.

There are so many rodent models available for preclinical target and drug discovery for #MASH. But which model offers the highest resemblance of the human disease?   The answer is simple. In the recent issue of Nature Metabolism, the renowned #LITMUS consortium concludes that Gubra’s GAN DIO-MASH mouse model ranks #1 for human proximity, a key indicator of clinical translatability, in terms of both metabolic relevance and ability to induce MASH-fibrosis. LITMUS compared a wide range of the most commonly used preclinical MASH models, evaluating their metabolic phenotype, liver histopathology and transcriptomics against corresponding MASH patient data.    We are very proud and grateful to be recognized by LITMUS as the provider of the most translational preclinical model.   Check out the paper and explore the objective ranking of preclinical models of MASH in the industry. #PreclinicalModel #PreclincalResearch #ClinicalTranslatability #MASLD #Publication #PreclinicalCRO #ResearchModels

Biomarker discovery process at binomial decision point (2BDP): Analytical pipeline to construct biomarker panel. Read the article here: https://lnkd.in/gm-yy55u

Explore the innovative realm of targeted spatial profiling in multi-omics, unlocking potential revolutionary therapeutic breakthroughs. https://ow.ly/lcGo50R9L5F #MedicalInnovation #MultiOmics #TherapeuticAdvances #TargetedBioscience