Sengenics’ Post

Every translational biologist that I have met has always wanted to put their "brick in the wall" of science that builds something amazing whether that be our understanding of ourselves or diseases that we face. To do this we need the best tools and finding biomarkers from our own immune system can provide essential information that can be leveraged to understand disease progression, effects of treatment and the mechanisms used in disease. Sengenics identifies these biomarkers. Could it help you? #proteomics #biomarkers #immunology #cancer #neuroscience

🔬 Organoids vs. Immortal Cell Lines 🧬 Are you curious about the latest advancements in cell culture technology? In this insightful blog post, CelVivo's Stephen Fey delves into the pros and cons of patient-derived organoids and immortal cell lines. Discover why 3D cultures might be the game-changer we need for more accurate drug testing and personalized medicine. Is it time for a shift in our research paradigms? 📖 Read more: https://lnkd.in/exMnyr7T #BiomedicalResearch #Organoids #CellCulture #Innovation #DrugDevelopment

Out Now! Clinical Operations Spotlight - Edition 02

𝗟𝗶𝗴𝗵𝘁-𝗥𝗲𝘀𝗽𝗼𝗻𝘀𝗶𝘃𝗲 𝗮𝗻𝗱 𝗗𝘂𝗮𝗹-𝗧𝗮𝗿𝗴𝗲𝘁𝗶𝗻𝗴 𝗟𝗶𝗽𝗼𝘀𝗼𝗺𝗲𝘀: 𝗙𝗿𝗼𝗺 𝗠𝗲𝗰𝗵𝗮𝗻𝗶𝘀𝗺𝘀 𝘁𝗼 𝗧𝗮𝗿𝗴𝗲𝘁𝗶𝗻𝗴 𝗦𝘁𝗿𝗮𝘁𝗲𝗴𝗶𝗲𝘀 In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the development of smart, stimuli-responsive nanocarriers that are capable of releasing their cargos in response to specific stimuli. These intelligent-responsive nanocarriers can be further surface-functionalized so as to achieve active tumor targeting in a sequential manner, which can be simply modulated by the stimuli. Continue reading here: https://lnkd.in/dqeJxzbK #excipinets #liposomes

📢 We are excited to present our new collection, "Exploring Novel In Vitro Models for Cystic Fibrosis Research," now open for submissions! 🚀🔬 https://lnkd.in/d75Z3Rkq Cystic fibrosis (CF) is a complex genetic disorder affecting the respiratory and digestive systems, often leading to chronic lung inflammation and pathogen infections. Current animal models face limitations in replicating CF's human complexities, highlighting the need for innovative in vitro approaches. With the recent approval of the “FDA Modernization ACT 2.0,” the use of complex in vitro cultures for drug testing is now a reality, offering more accurate research alternatives. This collection, led by Dr. Roberto Plebani, Dr. Yuncheng M. and, Dr. Domenico Mattoscio, welcomes articles focusing on novel in vitro models for CF research, with a particular interest in papers exploring 3D in vitro models, like organoids and organ-on-a-chip technology, which can enhance drug delivery predictions and provide insights into inflammation dynamics. 📃 Register your interest here: https://lnkd.in/di2q-s58 Manuscript Submission Deadline: 31 January 2025 #CysticFibrosis #CFResearch #InVitroModels #Organoids #OrganOnAChip #DrugDiscovery #Pharmacology #Research #InnovativeScience

There are so many rodent models available for preclinical target and drug discovery for #MASH. But which model offers the highest resemblance of the human disease?   The answer is simple. In the recent issue of Nature Metabolism, the renowned #LITMUS consortium concludes that Gubra’s GAN DIO-MASH mouse model ranks #1 for human proximity, a key indicator of clinical translatability, in terms of both metabolic relevance and ability to induce MASH-fibrosis. LITMUS compared a wide range of the most commonly used preclinical MASH models, evaluating their metabolic phenotype, liver histopathology and transcriptomics against corresponding MASH patient data.    We are very proud and grateful to be recognized by LITMUS as the provider of the most translational preclinical model.   Check out the paper and explore the objective ranking of preclinical models of MASH in the industry. #PreclinicalModel #PreclincalResearch #ClinicalTranslatability #MASLD #Publication #PreclinicalCRO #ResearchModels

Want to know more about Brain-Organoid-on-chip and NETRI’s irrigation technology? Join our webinar next week! #organonchip #brain #skin

Take a glance at the future of 3D cell culture (organoids/3D recustructured epitheliums/explants), innverated and irrigated, without pumps and compatible with automation. Just join.

We're excited to announce that we have three new articles now available on News Medical, one of the world’s leading open-access medical and life science hubs. One of these articles includes an interview with one of our scientists Jessica Tilman, explaining the functions of iPSC-derived microglia and their relevance to conditions like Alzheimer’s and other neurodegenerative diseases. Follow the links below to download these articles that showcase how iPSC-derived cells are being used to advance disease modeling and drug discovery; 1. Article: iPSC-Based Neuromuscular and Neuronal Models for ALS and Drug Discovery https://hubs.la/Q02QzXQs0 2. Article: Validating a tri-culture cortical model to advance neurodegenerative drug discovery https://hubs.la/Q02QzQHw0 3. Article (Interview): A Full Guide to Advanced in Vitro Models and Applications https://hubs.la/Q02QzY-m0 If you'd like to discuss how Axol Bioscience can unlock iPSC technology for your drug discovery and research, make sure to get in touch at operations@axolbio.com #iPSCs #DrugDiscovery #StemCells #biopharma

📢 Don’t miss out on our Webinar!! Dr. Heng Zhu, a renowned expert in the field of proteomics and molecular sciences. His expertise and research contributions have significantly advanced our understanding of protein biology and its implications for human health and disease.