AELIS FARMA’s Post

Hard to believe it’s already the last day of Neuroscience 2023. Did you have the chance to learn about our Proteinopathy Exploration Package? Visit booth 2716 to find out more about this new suite of assays purpose-built to provide a holistic view on the efficacy of drug candidates to combat Tau, α-Syn and TDP-43 aggregation. If you are developing drug candidates aiming to prevent or eliminate protein aggregation, this package can be an extremely valuable tool: - Based on human biology - Amenable for high-throughput screening - Delivers results in 6 weeks with 3 models screened in parallel To learn more about the unique advantages of Ncardia's Proteinopathy Exploration Package, click the link below – or drop by poster PSTR533.11 from 1-5pm today to discover the science behind these assays with Isabel Onofre. https://lnkd.in/enccJAxh You can also stop by booth 2716 to discuss your specific needs and challenges with Shushant Jain, Charles Leach, Marie Piazza and Juan Alcauter. Neuroscience 2023 Washington DC November 11-15 Ncardia Booth #2716 #SfN23 #Neuroscience2023

Modelling myelination in vitro is difficult due to the complexities of isolating and culturing primary oligodendrocyte. In this poster to be presented at #Neuroscience 2024, our scientists will outline an iPSC-derived model of myelination, with co-culture of oligodendrocytes and neurons, for use in multiple sclerosis drug discovery. https://okt.to/P0I7mV #SfN24 #multiplesclerosis #drugdiscovery

How to model myelination in vitro? Join Discovery | Charles River poster on iPSC derived coculture of oligodendrocytes & neurones during #Neuroscience 2024. Join Malika Bsibsi (presenting this poster) and our whole CNS team during #Neuroscience 2024

Complex #CNS challenges? We’ve got you covered. Discover CenExel, a leading #neuroscience clinical research site network with the expertise and track record to help you get more value from your asset.  Learn how now: https://lnkd.in/etsZeuG #ClinicalTrials #PatientRecruitment #Innovation #CenExel

The 𝗔𝗟𝗦 𝗗𝗿𝘂𝗴 𝗗𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗦𝘂𝗺𝗺𝗶𝘁 is returning to Boston to showcase booming industry investment in sporadic and familial pipelines, spotlight novel target innovation beyond TDP-43, foster patient-industry dialogue, and explore the promise of further accelerated approvals. View the full 3-day Agenda here: https://ter.li/u9ucsf Uniting with the same shared goal of innovating more effective, differentiated, and truly transformative ALS therapies, here are some of the 60+ organizations that have already confirmed their attendance. #ALS #CNS #DrugDevelopment #Neuroscience

A novel engineered assembloid platform may help accelerate therapeutic discovery for Parkinson’s disease (PD). Congratulations to Alp Ozgun, David Lomboni, Fabio Variola, and their team, for the important paper 📝 describing the development of a novel engineered assembloid platform to recapitulate key attributes of PD dysfunction in vitro. Visit our website to learn more and discover how the researchers used Axion’s next-generation Maestro Pro MEA platform to explore the dysfunctional dopaminergic network associated with PD in real time with no labels, dyes, or complicated steps.  🔗 https://bit.ly/3PGneLr #parkinsonsdiseaseresearch #iPSCs #neuroscience

Fully explore the human BBB with our iCell® Blood-Brain Barrier Kit! iCell® Blood-Brain Barrier Isogenic Kit is an off-the-shelf, ready-to-use, human iPSC-derived cell model with barrier integrity and functionality consistent with in vivo physiological properties necessary to create a complex, 3D cellular model. For assessment of drug permeability through the BBB using the iCell BBB Kit, our partner Visikol showed the presence and functionality of primary transportation mechanisms involved in the passage of compounds/molecules across the BBB, including efflux pumps such as P-glycoproteins (P-gp). This highlights the potential of the iCell BBB Kit as a robust readout during lead optimization. Read more about Visikol's services using the iCell BBB Kit here: https://ow.ly/KpCp50R8CGg The iCell BBB Isogenic Kit includes, iCell Astrocytes 2.0, iCell Brain Microvascular Endothelial Cells and iCell Pericytes, as well as media that enables long-term survival and superior functional performance. ORDER YOUR KIT NOW! https://ow.ly/JrI950R8CGe #BloodBrainBarrier #Neuroscience #DrugDiscovery #iPSC #FujifilmLifeSciences #StemCells #Visikol #BMEC #OrganOnAChip #OoC

🧠💉 Could brain parasites be the key to unlocking new therapies? Researchers have found an innovative way to bypass the blood-brain barrier by harnessing the natural abilities of the Toxoplasma gondii parasite. This groundbreaking approach could revolutionize how we deliver large therapeutic proteins, such as Cas9, to the brain. Imagine turning a notorious parasite into a tool for healing—what could this mean for the future of neurological treatments? Dive into the full article to explore the potential and challenges of this unconventional method! 📖 Read more about "Harnessing brain parasites for protein delivery" by Søren Hough, PhD https://lnkd.in/e44XEHZH #Biotech #Neuroscience #Innovation #MedicalResearch

#CellPostersSeries - Are you attending #SLAS2024 and working with commercial or proprietary human-iPSC-derived neurons to address your pharmacological questions?  Our San Diego-based cell electrophysiology lab has done some groundbreaking work on human-iPSC derived neurons. Download our poster presentation from ISSCR 2021 below to learn more about: 🔹 How our expert team measured the electrophysiological and pharmacological properties of iPSC-derived neural progenitors from Axol Bioscience Ltd.  🔹 Why we concluded that hiPSC-derived sensory neurons reproduced several key electrophysiological properties expected from mature sensory neurons, making these cells useful for supporting drug discovery programs for Pain.   ➡️ Connect with us to discuss the potential applications and implications of our research: schedule a 30-minute meeting with our CBO, Raymond Price, at SLAS in Boston: https://lnkd.in/gsEae8y5   #hIPSC #iPSC #neuronalcells #innovation #drugdiscovery #SLAS2024 #neuroscience

#citation Did you know that motoneurons rely on precise protein synthesis for proper axon growth and neuromuscular connectivity? 🧠 🧬 Recent findings on 𝙉𝙖𝙩𝙪𝙧𝙚 𝘾𝙤𝙢𝙢𝙪𝙣𝙞𝙘𝙖𝙩𝙞𝙤𝙣𝙨 from Universitätsklinikum Würzburg reveal a key player—hnRNP R—that regulates axonal protein production. In knockout models, reduced axon growth and impaired motor function were observed. This discovery highlights the critical role of hnRNP R in controlling the local production of essential proteins for healthy motor behavior. Restoring axonal O-GlcNAc levels can rescue these defects! Read more here: https://lnkd.in/d2Gz8UtB Cyagen is proud to contribute to this groundbreaking research with our 𝘏𝘯𝘳𝘯𝘱𝘳 knockout mice. 🐭 Learn more about our Knockout Catalog Models here: https://lnkd.in/gqxybj-x #Neuroscience #Motoneurons #ProteinSynthesis #AxonGrowth #NeuromuscularResearch #ScientificDiscovery #knockoutmice #mousemodel #biotech #biotechnology #scienceofreading