AJMC - The American Journal of Managed Care’s Post

Considerable progress has been made in the field of cancer over the last few decades, marked by significant advancements. Unfortunately, the escalating menace of drug-resistant bacteria poses a substantial challenge, undermining the progress in cancer treatment. People with cancer face a higher vulnerability to infections as their immune defenses are compromised. Surgical procedures and treatments create immense pressure on the immune system, increasing the susceptibility to infections. Read more ➡ https://lnkd.in/dP-ynr6c #amr #cancer #antimicrobialresistance #antibioticresistance

Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers https://lnkd.in/ezfrgg8Q

Intracelluar oncoproteins like KRAS function as oncodrivers and promote tumor growth by limiting the effectiveness of anti tumor activity of immune CD8+T cells. In vivo, KRASG12D-specific dIgA1, penetrated cancer cells and produced expulsion of oncoproteins and thereby limited the growth of KRASG12D-mutated ovarian and lung carcinomas in a manner dependent on CD8+ T cells. Also in vivo, dIgA specific for IDH1R132H reduced colon cancer growth, demonstrating effective targeting of a cytoplasmic oncodriver not associated with surface receptors. dIgA targeting of KRASG12D restricted tumor growth more effectively than small-molecule KRASG12D inhibitors, supporting the potential of this approach for the treatment of human cancer. #immunotherapy #cancer #dimericiga #kras

New research published in JAMA Network Open examined how different combinations of behavioral treatment and medication affect tobacco cessation and, going forward, how they can be used to increase the benefits of lung cancer screenings. The findings suggest that Tobacco Longitudinal Care (TLC) was most effective when implemented without modification and does not need additional pharmacist resources. Integrating the TLC program—which consists of frequent telephone coaching and over-the-counter combination nicotine replacement therapy (NRT)—with lung cancer screening was feasible and associated with clinically meaningful quit rates. In short, if we do not help people quit smoking, we will not adequately reap the benefits of lung cancer screening.

Up to 10% of #cancers are thought to be caused by #genetic changes that are passed from parent to child. The FDA has granted marketing authorization for [the Invitae Common Hereditary #Cancers Panel] blood test that detects inherited #genetic changes that may increase the risk of developing certain #cancers. The test is the first of its kind to be granted marketing authorization. "This particular [#germline #genetic] test is the first to have undergone FDA's critical review to demonstrate that it is safe and effective for its intended use"- #DrLoriMinasian @ NCI Division of Cancer Prevention, National Cancer Institute (NCI) #patient #access #reducedisparities #germlinetesting #genetictesting #precisionmedicine #precisiontherapy #clinicaltrials #precisionprevention https://lnkd.in/gb2ChzrP

With the use of weight loss drugs on the rise, their potential risks and unintended outcomes are still being researched. However, a recent Scandinavian cohort study provides reassuring news regarding GLP1 receptor agonist treatment and thyroid cancer risk. The study found no significant association between the two, offering peace of mind to healthcare providers and patients. While further research is needed to validate these findings and explore long-term effects, this news is a step forward in understanding the safety profile of weight loss drugs. #cancerrisk #weightlossdrugs

Nanocarriers mediated delivery of methotrexate is instrumental in treating auto-immune diseases and cancer

Why does antibiotic resistance matter? One reason is that it creates even poorer outcomes for people already struggling with disease. It’s critical that we do everything we can to preserve the efficacy of antibiotics for those who need them. If you’re a healthcare provider looking for better ways to talk with patients about antibiotics, check out our website and videos: https://lnkd.in/eXsdHChH

#Target IL-7 -- the multipotent cytokine that maintains the homeostasis of the immune system Interleukin 7 (IL-7) is a cytokine necessary for the adaptive immune system, which is critical for B cell development as well as proliferation and survival of memory and naive T cells, and T cell development in the thymus. IL-7 performs its biological functions mainly through the activation of the IL-7 receptor (IL-7R) . IL-7R is a heterodimer that is composed of the IL-7R α chain (CD127) and the common γ chain (CD132, IL-2Rγ) shared by multiple cytokines such as IL-2, IL-7, IL-4, IL-9, IL-15, and IL-21.  IL-7 and IL-7Rα promote cell survival and inhibit cell apoptosis mainly by the activation of JAK/STAT5 and PI3K-AKT mediated signal pathway. Furthermore, IL-7 also induces the activation of MAPK pathway. IL-7 and IL-7R have both pro- and anti-tumor functions. Cytokine-based immunotherapy has been used in cancer treatment, including CAR-T, mAbs and small molecule inhibitors. 🔹 DDXCELL provides IL-7 reporter cell line and antibodies to meet needs of drug research. 👉 Click the link to know more about products: https://lnkd.in/g6vBVkuM #drugdiscovery #celllinedevelopment #antibodies #drugdevelopment #cytokines #tumor

#TACE #HCC #liver #livercancer #China Immune checkpoint inhibitors and anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors with or without transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma (CHANCE2201): a target trial emulation study #advancedcancer #CHANCE2201 study #Lancet