Check out Helena Smolak's The Wall Street Journal/Dow Jones article to learn how our deal with Roche is “complementary to Roche's own gene editing strategy and aims to benefit its neuroscience portfolio...” 👉 https://lnkd.in/eS3Q56AH #RewritingRNA #RNAExonEdting #Neurocience #GeneTherapy
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We designed ioCRISPR-Ready Cells™ to reduce the time you need to spend in the lab to generate gene knockouts and run CRISPR screens in human iPSC-derived cells! Test a vial in your lab: https://hubs.ly/Q02fZsk20 #research #DrugDiscovery #ScienceCommunication #optiox #ioCells #iPSC #neuroscience #CRISPR #screens #GenomeEditing #GeneEditing #HTS #neuron #array
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A lot of neuroscientists don't realise their work is considered neurochemistry! Neurochemistry underpins all neuroscience and includes cellular, molecular, biochemical, and behavioural approaches. Spread the word! This quote comes from our Editor Spotlight of Hermona Soreq, our Senior Editor of the Gene Regulation & Genetics category in the Journal of Neurochemistry, as part of our upcoming Cholinergic Mechanisms Special Issue! You can read it here: https://ow.ly/V1rh50R8jW5 #WeAreNeurochemistry
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ioCRISPR-Ready Cells™ allow you to harness knockout experiments and screening capabilities very, very quickly.These iPSC-derived cells can be used with viral and sgRNA modalities! Get in touch if you'd like to learn more, we also have excellent technical support if you need help designing the screening experiment! #crispr #crisprcas9 #ipsc #neuroscience #screening #knockout
We designed ioCRISPR-Ready Cells™ to reduce the time you need to spend in the lab to generate gene knockouts and run CRISPR screens in human iPSC-derived cells! Test a vial in your lab: https://hubs.ly/Q02fZsk20 #research #DrugDiscovery #ScienceCommunication #optiox #ioCells #iPSC #neuroscience #CRISPR #screens #GenomeEditing #GeneEditing #HTS #neuron #array
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Applications of Brain-Tumour Organoids. Recent advances in cell culture technology have allowed the use of organoids as model systems for a myriad of applications such as personalised medicine, genetic engineering, cancer and invasion modelling, gene profiling, primary cell/tumour biobanks, drug screening, and metabolomic/ proteomic analyses https://lnkd.in/eFuEvMys #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum
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Indeed! Everyone doing molecular neuroscience is doing neurochemistry. Everyone doing brain metabolism is doing neurochemistry. Everyone looking at the molecular basis of behaviour is doing neurochemistry. Everyone doing anything with molecules in the nervous system is doing neurochemistry. #Neurochemistry - it makes you think!
A lot of neuroscientists don't realise their work is considered neurochemistry! Neurochemistry underpins all neuroscience and includes cellular, molecular, biochemical, and behavioural approaches. Spread the word! This quote comes from our Editor Spotlight of Hermona Soreq, our Senior Editor of the Gene Regulation & Genetics category in the Journal of Neurochemistry, as part of our upcoming Cholinergic Mechanisms Special Issue! You can read it here: https://ow.ly/V1rh50R8jW5 #WeAreNeurochemistry
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It is my immense pleasure to announce the publication of my latest review article titled "Exploring Parkinson-associated Kinases for CRISPR/Cas9-Based Gene Editing: Beyond Alpha-Synuclein" by Ageing Research Reviews Journal, Elsevier (Q1, Impact Factor: 13.1) ❤️ https://lnkd.in/dBPett7d I am immensely proud to have my work featured in one of the best journals in ageing and neuroscience. I would like to express my gratitude to the esteemed reviewers and the journal's editorial team for their valuable insights and support throughout the publication process. This review examines the potential of CRISPR/Cas9 gene editing technology in targeting kinases associated with Parkinson's disease (PD). We discuss the CRISPR/Cas9 system, as well as genes such as LRRK2 and PINK1 that are involved in PD. Additionally, we explore novel kinases that could be targeted and address concerns regarding off-target effects. Finally, we discuss future directions which hold promise for the development of gene editing-based therapies for PD. Link of my ResearchGate account: https://lnkd.in/gCS2YM-5 #Publication #Neuroscience #Ageing #Kinases #Anticancer #crisprcas9 #geneediting #parkinson #illustrations #neurodegeneration #elsevier #LRRK2 #PINK #PARKIN #AMPK #GRK #GAK #PKC #ABL #CDK #PhD
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☑️ *READ ABSTRACT BELOW:* Part 2: However, S100 gene expression was not limited to microglia but was also detected more broadly in uninfected stromal cells, mature and immature ChP cells, neural progenitor cells and importantly in bystander neurons suggesting propagation of the inflammatory response to bystander cells. Neurotransmitter transporter expression declined in uninfected neurons, accompanied by increased expression of genes promoting cellular senescence and cell death. Together, these studies underscore how an inflammatory response generated in HIV-infected microglia is propagated to multiple uninfected bystander cells ultimately resulting in the dysfunction and death of bystander neurons. Kong W, PNAS Nexus. 2024 Apr 29;3(5):pgae179. doi: 10.1093/pnasnexus/pgae179. PMID: 38737767; PMCID: PMC11086946. #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum
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Creativity is as important as knowledge / Director, Ph.D. Program in Sciences and Innovation in Medicine at Universidad del Desarrollo
Happy B-day Genomic Imprinting! "Genomic imprinting is the process by which only one copy of a gene in an individual (either from their mother or their father) is expressed, while the other copy is suppressed. Unlike genomic mutations that can affect the ability of inherited genes to be expressed, genomic imprinting does not affect the DNA sequence itself. Instead, gene expression is silenced by the epigenetic addition of chemical tags to the DNA during egg or sperm formation. Epigenetic tags on imprinted genes usually stay in place for the life of the individual. Definition from https://lnkd.in/exvFW8ga" https://lnkd.in/epsi3tDE #genetics #genomics #precisionmedicine #genomicmedicine #imprinting #dna #raredisease #epigenetics #epigenomics #development #health #disease #Angelman #Prader–Willi #brain #neurology #neurodegeneration #neuroscience #therapeutics #biomarkers #diagnostics #biotechnology #innovation #research #science #sciencecommunication
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Join us for a webinar to learn about the MERSCOPE 1000 Gene Panel for studying neurodegenerative diseases. Double your gene multiplexing capability with no compromise on data quality! Discover more with MERSCOPE 1000-plex! 👇 Vizgen
We invite you to join us for a webinar in collaboration with Labroots on Tuesday, March 12th at 1:00 PM EDT to learn about using the new MERSCOPE 1000-plex gene panel for studying neurodegenerative diseases. Title: Unveiling Brain Complexity with the MERSCOPE® Platform Using 1000-plex Gene Panels Presenters: Peter Reinhold, Global Product Manager, Assays and Reagents, Vizgen and Renchao Chen, PhD, Application Development Scientist, Vizgen Date: Tuesday, March 12th, 2024 Time: 10 AM PDT | 1 PM EDT | 6PM CET Duration: 1 hour Register for the webinar today: https://hubs.ly/Q02mD6hD0 #Vizgen #Webinar #MERSCOPE #MERFISH #SpatialOmics #1000Plex #Neurodegeneration #AlzheimersDisease #Neuroscience #MouseBrain #HumanBrain
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An innocent jump into the water, a car accident or a fall from a ladder or stairs can be fatal. It is not uncommon for these accidents to fracture, shatter or dislocate vertebrae, injuring the spinal cord. The prognosis for such people is usually bad, but a team of scientists from the Department of Neuroregeneration and the Centre of Reconstructive Neuroscience of the IEM CAS, which works on axon regeneration after spinal cord injury and restoration of motor skills, can change that in the future.🧠 Learn about promising gene therapy, blind alleys of experimental research and regeneration of nerve cells in the usually inhospitable environment of the central nervous system in an interview with neuroscientist Kristýna Kárová in the current issue of the magazine 👉 "Zázraky medicíny" (Miracles of Medicine). 👀 https://lnkd.in/eM4dDv-a (available only in Czech)
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