Augustine Therapeutics will be participating to the BIO-EUROPE conference in Munich, Germany on 6-8 November 2023. Sylvain Celanire, CEO will be available for one-on-one meetings throughout the 3-day conference. To schedule a meeting, please reach out to us via: https://lnkd.in/gRkjn8M We will be sharing the latest development on our small molecule HDAC6 inhibitor projects portfolio, including our peripheral-restricted clinical candidate AGT100216 advancing into regulatory development for Charcot-Marie-Tooth disease and Chemotherapy-induced neuropathies, as well as our brain penetrant selective HDAC6 inhibitor program for neurodegenerative diseases, including ALS. ➡ Agenda of Bio-Europe: https://lnkd.in/eXzpc2S2 #lifesciences #bioeurope #biopharma #CIPN #CMT #ALS #innovation
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🔬 Excited to present our latest scientific developments in Alzheimer’s disease (AD) at the #ADPD2024 Conference! 💡 “The small molecule GAL-201 belongs to a new pharmacological class of amyloid beta aggregation modulators that acts upstream of other known Aβ-targeting agents in Alzheimer’s disease,” explained Hermann Russ, M.D. Ph.D. founder, and Chief Scientific Officer of Galimedix Therapeutics, Inc. “The positive preclinical results presented at AD/PD™ 2024 demonstrate how treatment with GAL-201 has a potential neuroprotective effect and may also improve cognitive function.” These results further support that toxic Aβ oligomers and protofibrils are a major underlying cause of this devastating disease. We look forward to advancing this promising new drug candidate in development. 💊 Read more here: https://lnkd.in/dtqgVZSN #AlzheimersDisease #GAL201 #LifeScience
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One week to go before the American Heart Association Annual meeting (#AHA23) kicks off in Philadelphia. On behalf of our people at Cardiomedex, I am very excited to be sharing the latest results showing the clinical relevance of the diet-Induced Obese NASH Hamster for evaluating drugs targeting HFpEF during the poster session “The Next Generation of Heart Failure Research” on Sunday November 12th, from 3:30-4:45PM (poster #2223) This model shows severe heart failure with preserved ejection fraction (HFpEF) related to evident hepatocellular ballooning and portal/bridging (stage 2-3) fibrosis and develops alterations in kidney function as characterized by our subsidiary company Physiogenex. This preclinical model provides a unique opportunity to evaluate the efficacy of drugs targeting HFpEF in a clinically relevant model. If you are attending #AHA23, I would love to connect and share ideas. Otherwise, contact us online to set-up an appointment and/or discuss your drug development projects with us: https://lnkd.in/eWkX9McT #AHA23 #cardiovascular #heart_failure #HFpEF #NASH #MASH #preclinical #innovation #proof_of_concept
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We are excited to announce that #GOHIBIC (vilobelimab) has been selected by Biomedical Advanced Research and Development Authority (BARDA) as an investigational therapy to be assessed in a Phase 2 clinical platform study that explores potential new options for the treatment of #ARDS. The Phase 2 multicenter, randomized, double-blind, placebo-controlled trial, will evaluate the safety and efficacy of three selected novel host-directed therapeutics, including GOHIBIC, at approximately 60 U.S. sites, with a total target enrollment of 600 hospitalized adults with ARDS. Given vilobelimab’s potent inhibition of #C5a and a host-directed mechanism of action, we believe it has the potential for broader applicability as a potent anti-inflammatory agent in ARDS. Read the full press release here: https://lnkd.in/dSihN_yt
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President & CEO of Cytonics | Biotech Investor | Johns Hopkins School of Medicine | Moving From Insurmountable Challenge To Almost Certain Failure With Unbridled Enthusiasm
❗BREAKING❗1st Patient Dosed in Ph 1 Clinical Trial Last night 💉 we dosed our first patient in our Phase 1 clinical trial of CYT-108 for the treatment of osteoarthritis. The patient received 25mg of CYT-108, our recombinant Alpha-2-Macroglobulin variant. They were observed for 30 minutes and no acute adverse events were detected. This event marks our transition from a preclinical research company to a clinical-stage company, a massive milestone that underscores our commitment to transforming the treatment of osteoarthritis. 📅 Timeline and Next Steps This patient will receive their final dose in late September, with the last follow-up scheduled for January 2025. Over the next two months, we anticipate enrolling and dosing approximately 20 more patients, keeping us on track for the Phase 1 clinical report to be published in June 2025. Each step brings us closer to our goal of providing a disease-modifying treatment for osteoarthritis, potentially benefiting millions of patients worldwide. Many more updates to come! #arthritis #regenerativemedicine #clinicaltrials #Cytonics #biotechnology
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❗BREAKING❗1st Patient Dosed in Ph 1 Clinical Trial Last night 💉 we dosed our first patient in our Phase 1 clinical trial of CYT-108 for the treatment of osteoarthritis. The patient received 25mg of CYT-108, our recombinant Alpha-2-Macroglobulin variant. They were observed for 30 minutes and no acute adverse events were detected. This event marks our transition from a preclinical research company to a clinical-stage company, a massive milestone that underscores our commitment to transforming the treatment of osteoarthritis. 📅 Timeline and Next Steps This patient will receive their final dose in late September, with the last follow-up scheduled for January 2025. Over the next two months, we anticipate enrolling and dosing approximately 20 more patients, keeping us on track for the Phase 1 clinical report to be published in June 2025. Each step brings us closer to our goal of providing a disease-modifying treatment for osteoarthritis, potentially benefiting millions of patients worldwide. Many more updates to come! #arthritis #regenerativemedicine #clinicaltrials #Cytonics #biotechnology
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Innovating drug discovery & cell therapy with iPSCs | Senior Director of BD @ Ncardia | Follow for biotech content, from science to business
Meet our latest addition to Ncardia’s cell portfolio! Introducing Ncyte® aCardiomyocytes, our newest cell model for cardiovascular research and toxicity studies! Improve in vitro testing of new treatments for atrial arrhythmias or cardiotoxicity assessments with this cell model: 🔶 High purity and chamber specific 🔶 Based on human biology 🔶 Suitable for drug screening Ncyte® aCardiomyocytes can be applied throughout the entire drug discovery pipeline, from extensive screening to crucial decision-making stages in hit-to-lead and lead optimization processes. Learn more here: https://lnkd.in/dyZz_TwZ #stemcell #atrial #cardiacdisease #cardiotoxicity #humanbiology #Ncardia #CardiovascularResearch
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❗BREAKING❗1st Patient Dosed in Ph 1 Clinical Trial Last night 💉 we dosed our first patient in Cytonics Corporation's Phase 1 clinical trial of CYT-108 for the treatment of osteoarthritis. The patient received 25mg of CYT-108, our recombinant Alpha-2-Macroglobulin variant. They were observed for 30 minutes and no acute adverse events were detected. This event marks our transition from a preclinical research company to a clinical-stage company, a massive milestone that underscores our commitment to transforming the treatment of osteoarthritis. 📅 Timeline and Next Steps This patient will receive their final dose in late September, with the last follow-up scheduled for January 2025. Over the next two months, we anticipate enrolling and dosing approximately 20 more patients, keeping us on track for the Phase 1 clinical report to be published in June 2025. Each step brings us closer to our goal of providing a disease-modifying treatment for osteoarthritis, potentially benefiting millions of patients worldwide. Many more updates to come! #arthritis #regenerativemedicine #clinicaltrials #Cytonics #biotechnology
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Pleased to announce that we have entered into an exclusive agreement with Coya Therapeutics, Inc. for the development and commercialisation of COYA 302, an investigational combination biologic therapy for treatment of Amyotrophic Lateral Sclerosis (ALS). Patients with ALS, commonly known as Lou Gehrig’s disease, have few treatment options. The investigational combination biologic COYA 302 has the potential to make a meaningful difference to patients with this progressive neurodegenerative disease. This is the latest in our collaborations for innovative products and novel molecules, following our recent partnership with Jiangsu Hengrui for pyrotinib, Junshi Lifesciences for toripalimab, and digital therapeutics. For more details, visit: https://bit.ly/46QkPTY. We hope to reach many patients around the world with this promising biologic, in keeping with our aim of serving over 1.5 billion patients by 2030. #DrReddysXSustainability #WeAreDrReddys #GoodHealthCantWait #SDG3 (good health and well-being)
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The latest on health innovation in Edmonton, sponsored by Health Cities: - United Nurses of Alberta has questions about Recovery Alberta - Nanostics Inc. gets AHS data for machine learning - Pacylex Pharmaceuticals, Inc. presents cancer disruptor results https://lnkd.in/gK833EDe #yeghealth #yeginnovation
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FDA Approves Afami-cel Cellular Therapy for Advanced Synovial Sarcoma The FDA has granted accelerated approval to afamitresgene autoleucel (afami-cel), an engineered T-cell therapy targeting the MAGE-A4 protein, for advanced synovial sarcoma. This decision is based on the SPEARHEAD-1 trial, where 39% of heavily pretreated patients responded to the therapy, with a median response duration of 12 months and overall survival of 17 months. The approval represents a significant advancement in treatment options for synovial sarcoma. For more details, you can read the full article here: https://lnkd.in/eGnxzr9w #FDA #Clinicalresearch #TheraResearch
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European Patent Attorney
10moSee you in Munich Sylvain 😉