Bill Park’s Post

An elegant study published in EMBO Molecular Medicine by Gou Young Koh at the Korea Advanced Institute of Science and Technology (KAIST) and collaborators observed that T4 or PTU treatment can significantly alter thyroid gland vasculature and architecture by modulating follicular cell height, vascular density, and diameter, using IVIM Technology’s intravital microscope (IVM). In vivo imaging of thyroid tissues in T4 or PTU-treated mice showed significant changes in vascularity and follicular architecture. T4 decreased follicular cell height, vascular density, and vascular diameter, whereas PTU increased these parameters. PTU also induced endothelial cell proliferation and enhanced blood flow, indicating active vascular remodeling. Ultrastructural analysis revealed T4 decreased endothelial fenestrae but increased caveolae, while PTU increased fenestrae numbers without altering caveolae. These changes were specific to the thyroid gland and highlight the dynamic adaptation of thyroid vasculature in response to TSHR signaling. Explore the full story : https://buff.ly/4dCyKRM #Intravital #Imaging #Vascular #invivo #thyroid #Tissues #intravital #microscopy #IVM

An elegant study published in EMBO Molecular Medicine by Gou Young Koh at the Korea Advanced Institute of Science and Technology (KAIST) and collaborators observed that T4 or PTU treatment can significantly alter thyroid gland vasculature and architecture by modulating follicular cell height, vascular density, and diameter, using IVIM Technology’s intravital microscope (IVM). In vivo imaging of thyroid tissues in T4 or PTU-treated mice showed significant changes in vascularity and follicular architecture. T4 decreased follicular cell height, vascular density, and vascular diameter, whereas PTU increased these parameters. PTU also induced endothelial cell proliferation and enhanced blood flow, indicating active vascular remodeling. Ultrastructural analysis revealed T4 decreased endothelial fenestrae but increased caveolae, while PTU increased fenestrae numbers without altering caveolae. These changes were specific to the thyroid gland and highlight the dynamic adaptation of thyroid vasculature in response to TSHR signaling. Explore the full story : https://buff.ly/4dCyKRM #Intravital #Imaging #Vascular #invivo #thyroid #Tissues #intravital #microscopy #IVM

A brilliant study published in Biomed Optics Express by Jieun Moon, KAIST (Korea Advanced Institute of Science and Technology), and collaborators investigates how the processes of macrovesicular lipid droplet accumulation in hepatocytes and perisinusoidal collagen fiber deposition occur, observed using IVIM Technology's intravital microscope (IVM).   In the in vivo imaging of magnified 3D rendered images, distinctive histopathological features of advanced non-alcoholic fatty liver disease (NAFLD), such as the accumulation of macrovesicular lipid droplets (arrowheads) in hepatocytes and the perisinusoidal deposition of collagen fibers (arrows), were clearly identifiable. Additionally, we were able to quantify the average diameter of hepatic lipid droplets and the volumetric proportions occupied by hepatic lipid droplets and collagen fibers in the total imaging volume. In mice treated with STZ and fed a high-fat diet (HFD), significantly enlarged hepatic lipid droplets and increased proportions of collagen fibers were observed, indicating severe steatosis and fibrosis. In contrast, in mice fed only a high-fat diet without STZ treatment, smaller hepatic lipid droplets and a slightly lesser degree of steatosis were observed. Explore the full story : https://lnkd.in/dMHzTCBS   #Intravital #Imaging #NAFALD #invivo #Liver #intravital #microscopy #IVM Figure modified from J. Moon, et. al., Biomed Optics Express, 11(9):5132-5146 

What is so special about the advanced smooth surface of our implants? In one word: Biocompatibility. Studies have shown that smooth surfaces have a low degree of inflammation and foreign body response, as compared to other surfaces. To learn more, visit the link https://lnkd.in/dPSGajeK   #SmoothSilk #TheMotivaStandard Doloff JC, Veiseh O, de Mezerville R, et al. The surface topography of silicone breast implants mediates the foreign body response in mice, rabbits and humans. Nat Biomed Eng. Published online 2021. doi:10.1038/s41551-021-00739-4

We are continuing the highlights of 2023 publications with the use of our clinical #MSOT imaging technology (multispectral optoacoustic tomography). To showcase MSOT in clinical research, we have chosen the following 2023 highlight publication: “Hybrid reflected-ultrasound computed tomography versus B-mode-ultrasound for muscle scoring in spinal muscular atrophy.” In this study, Vera Danko and researchers from the Universitätsklinikum Erlangen leveraged a combination of MSOT and ultrasound imaging to provide additional qualitative and quantitative metrics for disease phenotyping in spinal muscular atrophy. For more details and access to the publication, follow this link: https://lnkd.in/dff7MrYF #optoacoustics #photoacoustics #clinicalresearch #SpinalMuscularAtrophy #SMA

#CD31 is a major regulator of innate immune response and inflammation in general, heavily expressed in #platelets, #leukocytes and #endothelialcells. What is amazing is to be able to mimic such regulation quite accurately with a 80 nanometer thick layer that can be applied to any device! https://lnkd.in/e9DpMYiX #InterventionalCardiology and #neurology are discovering the considerable promise of such coatings to put an end point to the (still universal) problem of #thrombosis vs #ischemia management following device implantation. I am honored to have the opportunity to share some of the latest results on AlchiMedics’ CD31 coating technology and how it may impact the design of #NeuralImplants for the Brain Computer Interface community. #BCI #NYBCI24 #GlialScarring #PatientSafety #DAPT LVTS - Laboratory for Vascular Translational Science

New Research Alert! Our latest article in the Journal of Ocular Biology explores the overestimation of cardiovascular and ophthalmological consequences linked to low-dose radiation. Key Insights: -Examines misconceptions surrounding low-dose radiation effects -Highlights the need for a balanced perspective on radiation safety -Aims to inform both medical professionals and patients Dive into the findings and join the conversation on this important topic! Read the full article here: https://lnkd.in/gVw9U9_F #OcularBiology #RadiationResearch #HealthInsights #CardiovascularHealth #Ophthalmology #MedicalResearch #AvensPublishingGroup #AvensJournals #Radiation

📣 Paper alert! 📣 During my PhD, we developed and characterized special radiation-sensitive echography contrast agents (nanodroplets). These are initially invisible on echography images, but upon irradiation convert into highly echogenic microbubbles, providing bright contrast signals 💡 . From these signals, we aimed to extract the dose deposition of ionizing radiation, to enable safer and more effective radiotherapy treatments 💪 . Previously, we extensively characterized this concept of “radiation-induced droplet vaporization” in non-live (phantom) objects. Today, I am happy to share that we managed to translate the technology also towards (healthy) rats 🐀 , thereby taking a next, critical step towards clinical translation 🏥 . In particular, we showed a promising relationship between the generated ultrasound contrast and the proton range, underlining the potential of the technology for in vivo proton range verification. Owing to the online echography during irradiation, the technology might even pave the way for real-time treatment interventions. For more information you can scan to QR code below, or access the paper here: https://lnkd.in/eUPRxniY And of course, you are very welcome to reach out for more information as well. Finally, I would like to thank all co-authors for the nice collaboration and the European Horizon 2020 Research and Innovation programme as well as the Research Foundation Flanders - FWO for their financial support. #protonrangeverification #protontherapy #newpublication #nanodroplets #ultrasoundimaging #echography #radiotherapy #cancertreatment #amphora

#Systemic #LightChain (LC) #amyloidosis (AL) is a rare and serious #disorder characterized by the abnormal accumulation of #amyloid proteins, specifically light chains, in various #tissues and #organs of the body leading to #organ #dysfunction. Early diagnosis and treatment are crucial to managing AL amyloidosis and improving patient outcomes. In an article recently published in #NatureCommunications (Nature Portfolio), Tim Schulte and colleagues from the #InstituteOfMolecularAndTranslationalCardiology, Stockholm University, Università degli Studi di Milano, #UniversityMedicalCenterGöttingen, Aligning Science Across Parkinson’s | ASAP, Università di Pavia, #InstitutodiRicercheFarmacologicheMarioNegriIRCCS, Libera Università Vita-Salute San Raffaele, IRCCS Policlinico San Donato, and The University of Göttingen report on their investigation of the #structural #interactions between amyloid fibrils and collagen in the #cardiac #tissue of a patient diagnosed with AL (light-chain) amyloidosis.   https://lnkd.in/dVanheb2 #AL59 #fibrils were purified from the #postmortem #heart of a patient with progressive heart failure and systemic AL amyloidosis. Structure of the purified AL59 fibrils was determined using electron cryomicroscopy (cryoEM) which revealed the #helical #arrangement of the fibrils. The cryoEM data also revealed the presence of a distinct additional polymer along with the amyloids. The additional distinct polymer was identified as #collagenVI (COLVI) by the LC-MS/MS analysis. Thus, the researchers observed that the amyloid fibrils form #helical #superstructures in association with collagen fibers. To confirm the AL59/COLVI interactions and determine the architecture of the complex, the authors applied electron cryotomography (cryoET). Reconstructed tomograms revealed the COLVI #decoration on majority of AL59 fibrils. This helical arrangement suggests a specific interaction between the amyloid and collagen molecules, which may contribute to the #pathological effects observed in the #cardiac #tissue of patients with AL amyloidosis. The findings indicate that the helical superstructures could play a critical role in the #stability and #persistence of #amyloid #deposits within the cardiac #extracellular #matrix. This interaction might also influence the #mechanical #properties of the cardiac tissue, potentially exacerbating cardiac #dysfunction. Understanding these molecular interactions provides insights into the #pathogenesis of AL amyloidosis and could inform the development of #therapeutic #strategies aimed at disrupting these pathological amyloid-collagen associations.   #SystemicLightChainAmyloidosis, #Cardiology, #AmyloidFibrils, #Collagen, #AL59Amyloid