BioISI - Biosystems & Integrative Sciences Institute’s Post

We are honored to introduce Prof. Emmanuel MARGEAT as an invited speaker at this year's Single Molecule Workshop. Prof. Margeat will talk about "Dissecting the structural dynamics of a GPCR using smFRET". He is Director of the Centre de Biologie Structurale, Montpellier, France. His lab advances single molecule biophysical methods and applies them to the study of macromolecular complexes at biological membranes. These are involved in membrane organization and remodeling, mechanical transduction and chemical signal transduction. Don't miss the opportunity to learn from him, ask your questions, and discuss your research challenges! October 8 - 10, 2024 Berlin, Germany ➡️Present your own results and submit your abstract by July 24: https://lnkd.in/dpXy-4A ➡️Register by September 6: https://lnkd.in/dpXy-4A #smFRET #molecules #spectroscopy #microscopy #fluorescence #materialsscience #lifescience

Our paper from the University of Tokyo on the glassy state in the living #activematter is in the PNAS Nexus. What are the different phases in #activematter, and how are their properties related to their intrinsic structure? These are important questions that researchers are seeking to answer. In our recent work at the University of Tokyo, we used a model active matter system, specifically a suspension of swarming bacteria, wild-type E. coli, to study the transition of different phases in active matter in 2D. We found that with the increasing bacterial population, the system transitions from a fluid-like state to a kinetically arrested glass-like amorphous phase. In the fluid phase, the collective motion of bacteria was apparent, while in the glassy phase, we observed the kinetically arrested microdomains. More details can be seen in our paper.

Excited to share my first JACS paper on the synthesis and photophysical properties of a 4 heptagons-nanographene! 🎉 In brief, this saddle-shaped molecular nanographene exhibits dual fluorescence and photoinduced electron transfer towards fullerenes. What I found especially exciting is how the heptagon rings play a key role in the electron transfer process! 🔦 ⚡ This work is the result of a collaboration with Prof. Xinliang Feng, under the Research Training Program Planar Carbon Lattice (RTG-PCL). Many thanks to everyone involved! 🙏 https://lnkd.in/esdXXTH4

From MBoC Design principles of Cdr2 node patterns in fission yeast cells Opalko et al. found a new role for the nucleus in positioning cytokinetic ring precursors. They combined particle-based simulations with experiments including anucleate and multinucleated cells. The work has implications for spatial patterning in biology. https://lnkd.in/ghyN85z3

I wanted to share our recent publication in the Journal of Protein Science. This collaborative work explores how cryogenic electron microscopy and solid state NMR work synergistically to describe a protein fibril assembly. Check it out, especially if you are interested in the pros and cons of different structural biology techniques! https://lnkd.in/gtUsVTRk

Let the research you do make noise! Yesterday, I had the privilege to attend the special guest lecture at Indian Institute of Technology, Delhi by Walter Chazin from the Center for Structural Biology, Vanderbilt University, which left me feeling motivated. 🔶Abstract of the talk: Action at the Replication Fork This lecture delves into the intricate world of DNA replication & repair in eukaryotes. Using cutting-edge cryo-electron microscopy, the dynamic role of the replication fork not only in copying DNA but also in identifying & fixing damage was explored. The research focuses on one fascinating enzyme, pol-prim, responsible for crafting RNA-DNA primers. By analyzing its flexible structure, we reveal how it switches between RNA & DNA synthesis. Additionally, RADX, a protein that regulates DNA repair by limiting the formation of structures, is crucial for mending broken strands. This talk will provide unique insight into how RADX serves as a negative regulator of the formation of RAD51 filaments at stalled and reversed replication forks. Photo credit: Amol Mishra

Gerty Cori uncovered the process of cellular energy storage and release, answering one of the most fundamental questions about how the human body works. In so doing, she and her husband and lifelong research partner, Carl, transformed the study of biology, proving that the clarity of molecular chemistry could and should be applied to the opaque mechanisms of biology. Cori was awarded the 1947 Nobel Prize in Physiology or Medicine. She was the first woman to be awarded the medicine prize. Learn more: https://bit.ly/2IgxsRF

Check out our latest paper in Applied Phyics Letter. Using state-of-the-art Nitrogen-Vacancy magnetometry, we found out that the spin cycloid in BiFeO3 survives at large compressive strains in contrary to previous experimental observations and theoretical predictions. We further simplified the cycloid propagation directions from three nominal directions to a single direction by applying anisotropic strain from NdGaO3 (001) substrate, an important step towards advancing magnetoelectric memory applications and magnonics studies. Congratulations to all authors! Read the full paper here: https://lnkd.in/eydUwDwc Laboratoire Albert Fert