Biotrial’s Post

Missed our webinar? Don’t worry! You can still catch all the breakthroughs in revolutionizing your #neurodegenerative drug discovery and development with our precise, multiplexed #biomarker assays. Watch our on-demand webinar and see how Inoviv is revolutionizing the field with advanced #proteomics solutions. Don’t miss out on this chance to fast-track your research goals. Watch here - https://lnkd.in/eQDGX3MV #Neurodegeneration #Neuroscience #DrugDiscovery

Brain-on-chips are emerging as promising tools for advancing neurological research and drug development. We recently connected with ETAP-Lab's CEO Nicolas Violle to hear how the CRO is combining microfluidics technology with its neurotoxin manufacturing capabilities to develop brain-on-chip models of Alzheimer’s, Parkinson’s, and ALS. When combined with high-content imaging capabilities, the company aspires to capture the intricacies of the human brain in vitro. Learn more about their advanced cell models and the potential impact of this approach within the field of #neuroscience in our latest publication: https://lnkd.in/eBvKPYB6 #organonchip #microfluidics #highcontentimaging

📢 New Application Note: In Vitro Brain Model Using NANOSTACKS™ 🧠 Excited to share our latest application note on developing a novel in vitro human brain model with NANOSTACKS™. This model includes an astrocytoma cell line and SH-SY5Y cells, pushing the boundaries of neurotoxicity research. 🔬 Key Findings: • Increased Neurotoxicity: Methylglyoxal showed increased neurotoxicity in our model with undifferentiated SH-SY5Y cells compared to monocultures. • Neurite Outgrowth Assay: Clomipramine’s neurotoxicity was assessed using a neurite outgrowth assay on differentiated SH-SY5Y cells, demonstrating NANOSTACKS™’ compatibility with imaging-based toxicity assays. 📈 Our research highlights the potential of NANOSTACKS™ for creating complex in vitro models, offering valuable insights for drug discovery and neurotoxicity testing. 📄 Download the full application note to learn more about this innovative approach! 🌟 #Neuroscience #InVitroModel #NANOSTACKS #Neurotoxicity #DrugDiscovery #BrainResearch #Innovation

💡 Welcome to the future where "brain-on-chip" technology becomes a cornerstone of neurological research!   🧠With traditional methods, developing neurological drugs have limitations in mimicking the human #brain complexity. New brain-on-chip models holds immense promise for transforming the field of neuroscience. That's what BIO-DIAMOND project aims to demonstrate through our neurotoxin manufacturing capabilities combined with NETRI’s NeuroFluidics technology and Revvity's high-content imaging equipment!   💊 Ultimately, our ambition is to better understand the mechanisms of progression of neurological diseases such as #Alzheimer's, #Parkinson's and #ALS, and increase the potential to streamline #DrugDevelopment for our pharmaceutical customers.   👉Have a look to Revvity's latest publication (free) with the interview of our CEO, Nicolas Violle https://lnkd.in/e6MT5y7t   More about our expertise: https://lnkd.in/eJkd5Bgy #neurology #preclinical #drugdiscovery #innovation #BrainOnChip model   BIO-DIAMOND project is funded by the French government as part of #France2030. #biotherapies #bioproduction

🌟 Unlocking the Mysteries of the Brain: Researchers have achieved a groundbreaking feat by transforming the brain's blood vessels into a cutting-edge "three-dimensional camera." 🧠💡 Using bioluminescence, typically employed to track cellular processes, these vessels now serve as detectors, shedding light on intricate brain functions with unprecedented detail. 🔬 Harnessing the Power of Light: This innovative technique overcomes the limitations of traditional imaging methods by sensitizing blood vessels to bioluminescence. Through MRI imaging, researchers can now observe the dilation of these vessels, offering a clearer picture of gene expression and cellular interactions within the brain's depths. 💡 Illuminating New Possibilities: This breakthrough holds immense potential for advancing neurological research, paving the way for comprehensive mapping of gene expression and understanding complex brain dynamics. From unraveling the mysteries of neurological diseases to gaining deeper insights into brain function, the implications are profound. Join us in celebrating this remarkable achievement and stay tuned for the transformative discoveries that lie ahead! #Neuroscience #Innovation #Bioluminescence #ResearchBreakthrough 🚀🔍

Highlighted Citation🔔 Differentiation of neuroblastoma cells is a critical step for neuroscience. Up to now, neuronal differentiation has been monitored and detected by conventional methods. Magnetic levitation (MagLev) is a newly developed simple and cost-effective methodology that can perform sensitive density-based measurements without the need for labeling or tags. Published via #PMC in April, Exploring Neuronal Differentiation Profiles in SH-SY5Y Cells through Magnetic Levitation Analysis, the researchers utilized the MagLev technique to sort SH-SY5Y cells based on density variations to analyze neuronal differentiation. The findings revealed that MagLev allows for rapid, label-free, and straightforward sorting, making it possible to analyze cell differentiation at the single-cell level. Live or Dead™ Cell Viability Assay and propidium iodide (PI) dyes were used for live/dead analysis and visualized by a fluorescence microscope. Read the full article https://lnkd.in/gWTajTh3 #citation #biotechnology #neuroscience

#Neuroscience research has traditionally relied on primary neuronal cell cultures, which can be limited and challenging to work with. This is particularly critical in drug discovery for neurodegenerative diseases, where robust and scalable models are essential. Stem cell-derived neurons, particularly human iCell® Neurons, offer a scalable solution, addressing the limitations of primary cell cultures. These neurons provide a physiologically relevant environment for studying human drug targets in terminally differentiated, postmitotic cells. At Nanion Technologies, in collaboration with FUJIFILM Cellular Dynamics, Inc, we have prepared an 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗡𝗼𝘁𝗲 that may interest researchers working in neuroscience drug discovery. Here are a few highlights from this AppNote: ◾ Human iPSC-derived neurons, such as iCell® Neurons, offer a scalable, flexible, and cost-effective solution for neuroscience research. ◾ These neurons were successfully utilized on the Patchliner, facilitating detailed electrophysiological studies. The Patchliner’s capabilities allowed for simultaneous recording from multiple cells, providing robust data. ◾ iCell® Neurons express key ion channels, including NaV, KV, and GABAA receptors, and demonstrate electrophysiological properties aligning closely with those observed in manual patch clamp studies, providing reliable data for neurotoxicity, disease research, and drug discovery. ➡ For full details, 𝗱𝗼𝘄𝗻𝗹𝗼𝗮𝗱 𝗼𝘂𝗿 𝗮𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗻𝗼𝘁𝗲 here: https://lnkd.in/gAqK7PYq #Neuroscience #DrugDiscovery #hiPSC #IonChannels #iPSC #neurons #PatchClamp

Read our latest news at Neuro-Bio Ltd where I am speaking at “Club Ultima Hora” Debate Forum in Palma de Mallorca - 8th February 2024. The talk is focused on exploring the future of technology, the internet, its utilization and its impact on the human brain. #neuroscience #humanbrain #technology #scienceandtechnology

On the first day of ALS awareness month, we reaffirm our commitment to advancing research in the fight against Amyotrophic Lateral Sclerosis (ALS). At Neuroservices-Alliance, we provide specialized electrophysiological assays that are crucial for developing new therapies aimed at alleviating symptoms and extending quality of life for those affected by ALS: 🔹 in vitro models (iPSC-derived motor neurons from ALS patients, brain slice assays from ALS models) 🔹 in vivo models exhibiting degeneration of motor neurons Through precise measurements of neuronal properties, our team supports pharmaceutical and academic researchers in their quest to uncover new treatments that can slow the progression of ALS, manage its symptoms, and ultimately, find a cure.   ✉️ Let’s connect and explore how our expertise can support your ALS research projects.   #ALSAwareness #EndALS #CellElectrophysiology #Neuroscience #ALSResearch #DrugDiscovery

Hello LinkedIn colleagues! After enjoying the holidays and celebrating the dawn of 2024, one of my resolutions is to be more active here. As a new PhD, I can think of no better way to start than sharing insights into how I spent my career during the last 5(ish) years. My thesis, "Effects of Cannabinoid 2 Receptor Activation in Brain Microvascular Endothelial Cells," explored the cerebrovascular protective potential of CB2R activation in the brain. In a nutshell, my experiments (especially those using a novel, chromenopyrazole-based CB2R agonist) revealed that neurovascular CB2R activation has remarkable, therapeutically promising effects: 1) Restoring physical barrier integrity. 2) Attenuating inflammation-induced ICAM-1 expression. 3) Enhancing wound repair speed in brain endothelial cells. For more details, check out my publication in Neuroimmune Pharmacology and Therapeutics. You can learn more about the cell signaling events mediated by endothelial CB2R! What are your thoughts? Are cannabinoids valuable medicines in neuroscience? Can we therapeutically target the cerebral vasculature to circumvent the challenges with drug delivery to the brain? Let's start a conversation! #PhDChat #Neuroscience #BloodBrainBarrier #Cannabinoids #Research #ScienceCommunication