FAS Kits Advance Laboratory Detection of Synthetic Opioids and Emerging Drugs of Concern, Support Overdose Crisis Countermeasures ► https://loom.ly/aDl6mww The original FAS Kit, launched in 2019, contained 120 fentanyl analog reference materials. Today, the FAS Kit collection has grown to provide coverage of 310 synthetic opioids and other emerging drugs of concern. FAS Kits are available free-of-charge to qualified labs!
Cayman Chemical’s Post
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When it comes to screening for illicit drugs and novel psychoactive substances (#NPS), there are various analytical techniques available, each with its own advantages and limitations. Read this article to know what to consider when comparing immunoassays, gas chromatography-mass spectrometry (GC-MS), and high-resolution mass spectrometry (HRMS). #ForensicScience #AnalyticalChemistry #LCMSMS #MassSpectrometry
Analytical techniques for novel psychoactive substances (NPS) screening
linkedin.com
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Discover selected sets of Building Blocks in the Chemspace series 'Molecule Builder' for the analog synthesis of recently approved drugs! In Iptacopan synthesis, a final step involves the reaction of substituted indole with a piperidine derivative. Explore two sets of Building Blocks – indoles (1766 compounds) (https://buff.ly/3HkLRJ1) and substituted piperidines (484 compounds) (https://buff.ly/48TjcGz), serving as a perfect starting point for your research. Iptacopan (FABHALTA®) received FDA approval last December for treating the rare blood disorder paroxysmal nocturnal hemoglobinuria (PNH). This first-in-class, oral, highly selective inhibitor targets factor B (FB), a key component of the alternative pathway (AP) of the complement system. Implicated in various immune responses, the AP also holds promise in treating human diseases like age-related macular degeneration, atypical hemolytic uremic syndrome (aHUS), and various glomerular diseases. #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures
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On May 20th, we co-hosted the #webinar "Insights into Synthetic Drug Trends: Essential Knowledge for CSOs in Africa", together with UYDEL, DFAF, ISSUP, RUN, and UAPA. The webinar shed light on #Synthetic #Drug #Trends globally, the Global Position Paper on #Recovery, and the #Declaration of Oviedo, and provided a recap of the 67th Commission on Narcotic Drugs. You can now watch the webinar online! https://lnkd.in/dy8subY8
Recap – Webinar on Insights into Synthetic Drug Trends: Essential Knowledge for CSOs in Africa - World Federation Against Drugs
https://wfad.se
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Lots of my connections will have also worked on EGFR inhibitors and/or protein degradation, so just to share a comprehensive recent review describing EGFR PROTACs from 2016 onwards and the emergence of this modality as a new strategy to overcome the drug resistance issues of now four generations of EGFR inhibitors. https://lnkd.in/et4YWKmS
The next generation of EGFR inhibitors: a patenting perspective of PROTACs based EGFR degraders
tandfonline.com
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A GSK—MMV partnership that has produced a clinical candidate with the potential to rapidly treat drug-resistant uncomplicated #malaria has been awarded the Society of Chemical Industry (SCI) Innovation Award. The candidate, GSK484, is the result of a collaboration that began in 2012 to identify new treatments to address the growing threat of #resistance to antimalarial medicines. GSK484 is a novel molecule (non-artemisinin) and a candidate for development in a simplified dosing regimen. Read more about this innovative collaboration and its implications in the fight against antimalarial drug resistance: bit.ly/MMV_GSK
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You're all cordially invited to read “Rational Design and Synthesis of HSF1-PROTACs for Anticancer Drug Development” 👉https://ow.ly/TyaQ50PQ0u3 #mdpimolecules #molecules_mdpi
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Shifted-excitation Raman difference spectroscopy (SERDS) is a technique that is capable of reducing the interference caused by fluorescence and improve the potential of Raman for distinguishing drug compounds in seized samples with fluorescent additives. Here, 43 drugs were analyzed to show the practical application of SERDS. Link: https://ow.ly/J13n50PL3IA
Evaluation of Shifted-Excitation Raman Difference Spectroscopy and Comparison to Ordinary Portable Raman Spectroscopy in Identification of Seized Drugs
spectroscopyonline.com
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I am thrilled to share with you that Chemistry World Magazine from Royal Society of Chemistry has covered our latest article on polyamorphism. Check it out!
A team prepared three amorphous forms of the diuretic drug hydrochlorothiazide and analysed them, determining that they have distinct properties and distinct types of disorder. In other words, they are polyamorphs.
New insights into polyamorphism could influence how drugs are formulated
chemistryworld.com
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Increase confidence through precision analysis with our comprehensive drug profiles. Our assays enable increased specificity to detect the lowest levels of substances, which correlates to a reduction in false positives. https://bit.ly/3UUE8J2
Comprehensive drug profiles - Insights
news.mayocliniclabs.com
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