Celmatix’s Post

As many as 1 in 10 women of reproductive age will have polycystic ovarian syndrome. This syndrome not only causes irregular periods and ovarian cysts but can also lead to reproductive complications and serious metabolic disorders. How immune system alterations affect each of these physiological processes wasn't known until now. A group of scientists investigated immune cell populations in a mouse model of polycystic ovarian syndrome (PCOS) with hyperandrogenism -- a major feature of PCOS. The results show specific and differentiated immune cell alterations in reproductive organs, in fat tissue, and in the blood and lymph nodes of affected mice. With these discoveries, new therapies targeting specific immune cell populations in specific tissues could now be developed. “Polycystic ovary syndrome affects different tissues in unique ways. Potential treatments would need to be carefully tailored to target specific tissue dysfunctions,” said Elisabet Stener-Victorin, lead author of the study published in Advanced Science. https://lnkd.in/d-SFx-VJ #PCOS #reproduction #immunesystem

A recent study from Indiana University found that hydroxyurea significantly decreases infections in individuals with sickle cell disease. This breakthrough could lead to improved quality of life for millions worldwide! 🔬 Science at Work: Hydroxyurea, a medication typically used to treat certain types of cancer, has shown remarkable results in reducing infections in sickle cell patients by boosting fetal hemoglobin levels. 🌈 Hope for the Future: With fewer infections, individuals living with sickle cell disease can enjoy a better quality of life, fewer hospital visits, and enhanced overall well-being. It's a step forward in managing this challenging condition. 💡 What's Next?: Researchers are excited about the potential of hydroxyurea and are exploring further applications and optimizations to make treatments even more effective for those with sickle cell disease. Click here to read the full article: https://lnkd.in/g7WqXREJ #sicklecell #pediatriconcology #pediatrichematology #indianauniversity #hydroxyurea #cancerresearch #APHON

From X-linked conditions to autoimmune disorders to cancer, the X chromosome, and specifically the phenomena of X-inactivation, are an all-important part of women's health. In the years since I founded Remember The Girls, it's been exciting to witness this body of research grow and I hope it will lead to an increase of female cell lines and animal models in preclinical studies, greater sex-specific reporting in research, and improvements in diagnosis and treatment for women. #Xinactivation #Xchromosome #RememberTheGirls

Did you know that cervical cancer is the fourth most common cancer in women? Detecting it early is vital for a successful cure, although its management can potentially affect fertility. However, with Fertility Preservation, new possibilities arise for individuals who aspire to start a family after recovering from cancer. Learn more about fertility preservation in cancer patients and stay informed about the latest advancements in our Fellowship in Reproductive Medicine. To know more, visit https://lnkd.in/gpnTJDB4 or Call on +91 9513453460 #LearnWithMedline #CervicalCancerAwareness #FertilityPreservation #ReproductiveMedicine #Facts #Information

Breakthrough in Uterine Fibroid Research! A Northwestern Medicine study has made significant progress in understanding uterine fibroids. Key findings: ➡️ 24 new risk loci identified: Researchers analyzed data from over 20,000 fibroid cases and pinpointed 24 new genetic locations associated with an increased risk of developing fibroids. ➡️ Immune cells implicated: Previously, smooth muscle cells contribute to uterine fibroids. This study highlights the role of certain immune cells as well. ➡️ Nearly 400 genes linked to fibroids: By integrating various data sets, the research team identified nearly 400 genes potentially contributing to fibroid development. ➡️ More inclusive research: This study included data from diverse ancestries, providing a more comprehensive picture of fibroid risk compared to past studies. Read the full article from Northwestern Medicine: https://bit.ly/4arSPsn Ask your doctor if Sonata may be right for you. Side effects may include bleeding, spotting, cramping, and/or discharge. For Safety Information or to learn more, visit https://lnkd.in/gQMnmC3q. #fibroids #womenshealth #genetics #research #northwesternmedicine

Heart organoids simulate pregestational diabetes-induced congenital heart disease . An advanced human heart organoid system can be used to model embryonic heart development under pregestational diabetes-like conditions, researchers report. The organoids recapitulate hallmarks of pregestational diabetes-induced congenital heart disease found in mice and humans. The findings also showed that endoplasmic reticulum (ER) stress and lipid imbalance are critical factors contributing to these disorders, which could be ameliorated with exposure to omega-3s. #ScienceDailynews #InnovativeResearch #NextGenScience #ExploringFrontiers

Fascinating research on mechanisms steering our immune response by looking into differences in female versus male cells. A team from the Stanford University School of Medicine has discovered a mechanism that could explain the higher prevalence of autoimmune diseases in women published in Cell Press. It highlights how performing more research on the differences between male and female systems (cells, organoids, animal models, and clinical trials) offers new ways for researchers and drug developers to better understand disease mechanisms and find new targets to develop safer and more effective treatments for autoimmune and other diseases for both men and women.   Females have two X chromosomes, containing a large part of the information for our immune system, while males have one X and one Y chromosome. To ensure the balanced expression of X-linked genes, females undergo a process called X-chromosome inactivation, where one of the X chromosomes in each cell is turned off. This process is facilitated by a specific type of RNA called Xist, which attracts proteins to silence the extra X chromosome. The Stanford team identified nearly 100 proteins involved in this process. Many of these proteins are related to autoimmune disorders, suggesting a potential link between Xist and the immune system. One comment of the author emphasizes the opportunities for researchers to compare sex differences starting in cells: 'Every cell in a woman’s body produces Xist. But for several decades, we’ve used a male cell line as the standard of reference', while 80% of patients with autoimmune diseases are women. Researching the different cellular mechanisms between female and male systems, as highlighted in the X-chromosome inactivation process and its associated proteins, presents promising areas for research. This finding could lead to valuable insights for developing diagnostic tests and safer and more effective treatments for both men and women. The publication is also subject to this NYT article 'Why Do Women Have More Autoimmune Diseases? Study Points to X Chromosome': https://lnkd.in/d4XhNxKU #research #autoimmune #sexdifferences #drugdevelopment #diseaseprevalence #biomedicalresearch #opportunitiesforgroundbreakingresearch #precisionmedicine

Exciting findings emerge from recent Alzheimer's disease research! A groundbreaking study by Jose L. Cantero, Mercedes Atienza, Isabel Sastre, and María Jesús Bullido sheds light on the potential link between herpes simplex virus type 1 (HSV-1) infection and Alzheimer's pathology. Their research reveals that higher levels of anti-HSV IgG, indicating past exposure to the virus, correlate with increased amyloid-beta (Aβ) accumulation in specific brain regions among cognitively normal older adults. Notably, these regions exhibit altered functional connectivity patterns, potentially signaling early neuronal dysfunction. Of particular interest, these associations are heightened in individuals carrying the APOE4 gene variant, a major genetic risk factor for Alzheimer's. Importantly, while anti-HSV IgG levels show no direct connection to cognitive decline or blood markers of neurodegeneration, they may offer critical insights into Alzheimer's risk assessment and early intervention strategies. This study underscores the significance of exploring viral contributions to neurodegenerative diseases and paves the way for new avenues in Alzheimer's research. #AlzheimersResearch #HSV1 #Neuroscience #APOE4 #BrainHealth

Recent advancements in newborn screening are setting the stage for significant breakthroughs in precision medicine and paediatric care. Our latest webinar brought together leading geneticists and healthcare professionals to discuss these developments and their potential to transform healthcare practices. 👶 Thanks to Wendy Chung, Holly Peay, and Kira Dineen, MS, LCGC, CG(ASCP)CM for sharing insights on integrating genome sequencing into newborn screening, enhancing early detection, and improving patient outcomes. 🙏 Explore the insights from this fascinating discussion. 👇 https://lnkd.in/gsuwka9z #clinicaltrials #precisionmedicine #newbornscreening