Centre for Healthy Longevity’s Post

As professionals, we all want to keep brain sharp and productive at any age, right? We know that the brain is the Chief Operating Officer of our lives, yet often people are surprised to learn that brain is the most vulnerable organ in the body. During my research dissertation on mechanisms of brain ageing and potential strategies for Alzheimer’s disease prevention, I found many facts explaining why mitochondrial health is the key factor to keep the brain healthy during the life span. I like this great talk from Associate Professor Evandro Fei Fang about mitochondrial dysfunction related to Alzheimer’s disease and protective role of Urolitin A (see below). What is Urolithin A? It is a postbiotic compound that is produced by specific gut bacteria, when we eat food rich in polyphenols like pomegranates, berries, nuts, green tea, etc. Only about 40% of people naturally have the right gut microbiome composition to efficiently produce Urolithin A from these dietary polyphenols, based on the recent research. It means that around 60% people may not produce adequate levels of Urolithin A from diet alone. This is likely due to differences in gut microbiome composition between individuals. Factors like genetics, diet, lifestyle, stress response and existing chronical conditions can impact the gut microbiome and reduce the ability to produce Urolithin A from polyphenols. Urolithin A has been shown to have beneficial effects on mitochondrial function and cellular vitality, thus supporting brain health and cognitive reserve. In addition, the positive effects have been reported to support muscle, metabolic and gut health, extending healthy years of life. While continued learning is undoubtedly important for brain health, it is clear that a more comprehensive approach is necessary for healthy longevity. What’s your thoughts? What do you do for yourself to ensure brain health throughout the life? #ageingbiology #neuroscience #alzheimersdisease #innovation #urolithinA #healthyageing #longevity #longevitymedicine #brainhealth

How are academic, industry and government partners driving the precision #neuroscience revolution ... as individual contributors and within the Global Neurodegeneration Proteomics Consortium?     Now available! Chris Whelan, PhD, Carlos Cruchaga, PhD, and Keenan Walker, PhD, discuss their work measuring protein abundance and function via multiplex proteomics to build more detailed characterizations of the biological systems underlying neurodegenerative diseases.     Access the on-demand webinar: https://bit.ly/3SdOT8r     #Alzheimers #neuroscience #proteomics #biomarkers 

🧠 Unraveling the Complex Biology of Parkinson's Disease 🔬 Parkinson's disease is a multifaceted disorder involving a complex interplay of genetic, environmental, and age-related factors. This comprehensive review delves into the latest research on the pathophysiology of PD, from 𝛼-synuclein aggregation to the gut-brain axis. 🌿 As professionals in the neuroscience and healthcare fields, understanding the biological underpinnings of PD is crucial for developing targeted therapies and improving patient care. What aspects of PD biology do you find most intriguing or challenging? 🤔 Read the full article for an in-depth exploration of this complex disorder: https://lnkd.in/d9MEXPUt #ParkinsonsDisease #Neuroscience #HealthcareInnovation

How are academic, industry and government partners driving the precision #neuroscience revolution ... as individual contributors and within the Global Neurodegeneration Proteomics Consortium? Now available! Chris Whelan, PhD, Carlos Cruchaga, PhD, and Keenan Walker, PhD, discuss their work measuring protein abundance and function via multiplex proteomics to build more detailed characterizations of the biological systems underlying neurodegenerative diseases. Access the on-demand webinar: https://bit.ly/3SdOT8r #Alzheimers #neuroscience #proteomics #biomarkers

How are academic, industry and government partners driving the precision #neuroscience revolution ... as individual contributors and within the Global Neurodegeneration Proteomics Consortium?     Now available! Chris Whelan, PhD, Carlos Cruchaga, PhD, and Keenan Walker, PhD, discuss their work measuring protein abundance and function via multiplex proteomics to build more detailed characterizations of the biological systems underlying neurodegenerative diseases.     Access the on-demand webinar: https://bit.ly/3SdOT8r     #Alzheimers #neuroscience #proteomics #biomarkers 

How are academic, industry and government partners driving the precision #neuroscience revolution ... as individual contributors and within the Global Neurodegeneration Proteomics Consortium? Now available! Chris Whelan, PhD, Carlos Cruchaga, PhD, and Keenan Walker, PhD, discuss their work measuring protein abundance and function via multiplex proteomics to build more detailed characterizations of the biological systems underlying neurodegenerative diseases. Access the on-demand webinar: https://bit.ly/3SdOT8r #Alzheimers #neuroscience #proteomics #biomarkers

Excellent panel presentation and discussion on proteomics in neuroscience discovery and development. 

Lab-grown neurons with two distinct genetic makeups, differentially labeled with red and green fluorescent proteins, allow for visual differentiation in a co-culture context. #biotechnology #neuroscience #sciencecommunication #cellimaging #neuron #neuroimaging

N-terminal acetylated alpha synuclein is observed in #Parkinsons Disease. Learn more about StressMarq's alpha synuclein proteins used to study neurodegeneration: #neuroscience https://bit.ly/3oh9V4Y

💡 Parkinson’s & Alzheimer’s link to toxic protein aggregates, driving the need for new treatments. 🐝 Inspired by wasp venom, Dr. Yuri Alves de Oliveira Só et al's peptides Fraternine-10 and Octovespin show promise in disrupting and preventing the formation of fibrils associated with these diseases. ⚙️ Molecular dynamics simulations reveal their therapeutic potential. 🤔 How can we further leverage nature-inspired molecules like these to combat #neurodegenerative diseases? Universidade de Brasília #Neuroscience #Bioinspiration 🧩