Post-Doctoral Research Fellow at University of Toronto | Lab of Dr. Alan R Davidson: Departments of Biochemistry and Molecular Genetics in the Faculty of Medicine | anti-CRISPR, CRISPR-Cas, molecular mechanisms, phage
A super interesting new paper titled, "The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation" has just been published. Click on the link below for details. #proteasome #science #ubiquitinationindependentdegradation https://lnkd.in/gT2gP4_V
Signal-dependent formation of #mitochondria ! A research team led by Prof. Nils Wiedemann, Prof. Carola Hunte, and Prof. Martin van der Laan, unveiled the precise import mechanism by which mitochondrial proteins with signal sequences are imported into the mitochondria. They discovered that these proteins are imported into the mitochondria via a unique negatively charged groove. Read more in the The University of Freiburg's press release: https://lnkd.in/ez-mwrKW Prof. Nils Wiedemann will be elaborating on this discovery in his talk during #TargetingMitochondria2023 this October! Learn more about Prof. Wiedmann's talk: https://lnkd.in/eFnZQtXs #TargetingMitochondria #mitochondria #research #signaling #proteins #scienceandtechnology #scientificresearch #sciencecommunication
📢 Conscience has released the results of CACHE Challenge #1, which aimed to predict "hits" for Parkinson's disease drugs through computational models. Conducted in partnership with The Structural Genomics Consortium (SGC) and funded by The Michael J. Fox Foundation for Parkinson's Research, the challenge has yielded seven promising discoveries for familial Parkinson's disease. The CACHE Challenge has two key outcomes: firstly, new discoveries that can help advance novel treatments for Parkinson’s disease, and secondly, prospective benchmarking of multiple computational methods to reveal the state-of-the-art and guide future progress. Conscience has now made the entire experimental dataset of the CACHE Challenge available to the public, including the chemical structures of all the molecules tested and associated computational methods. #Conscience #CACHEChallenge #ParkinsonsDisease #DrugDiscovery #ComputationalModels #OpenScience
New research, publishing December 21st in the open access journal in PLOS Biology, shows that tears from women contain chemicals that block aggression in men. The study led by Shani Agron at the Weizmann Institute of Science, Israel, finds that sniffing tears leads to reduced brain activity related to aggression, which results is less aggressive behavior. Men exposed to women’s tears showed a 40% reduction in aggressive behavior. Brain imaging revealed decreased activity in aggression-related regions when men sniffed women’s tears. The study provides evidence of social chemosignaling affecting human aggression, similar to findings in animals. https://lnkd.in/gCfNZ8p5
🎯🧬 Marker Proteins: Signposts of Cellular Identity! ✨ Discover the significance of marker proteins in cell biology! These vital molecules help identify cell types and play crucial roles in research and clinical settings. Let's explore their importance in understanding cellular diversity and disease. #MarkerProteins #CellBiology #Research #Science #AladdinScientific Aladdin Scientific：https://lnkd.in/gXzkdRqv
Science and Medical Content Writer | Communications Specialist | Bridging Science and Society
A study from the Weizmann Institute of Science reveals that human tears contain chemicals reducing aggression in others, solving the mystery of why people cry. Published in PLOS Biology, the research shows that when men smell tears from women, their brain activity related to aggression decreases by around 44 percent. The study suggests tears activate olfactory receptors, altering aggression-related brain circuits, and the calming effect is observed not only in humans but also in blind mole rats and mice. #PLOSBiologyResearch #HumanBehavior #OlfactoryReceptors
Looking for PhD position | Molecular Biologist|Researcher|Computer aided drug discovery
🔬 **Revisiting Telomere Biology: Unveiling the Dual End-Replication Problem** 🔬 Half a century ago, the discovery of telomeres by scientists Jim Watson and Alexey Olovnikov shed light on a fundamental puzzle: how our DNA gets copied accurately during replication. The subsequent identification of telomerase by Liz Blackburn and Carol Greider seemed to solve the mystery. However, new research published in Nature challenges this conventional wisdom, revealing a deeper complexity. Recent findings suggest not one, but two end-replication problems, intricately tied to the replication of both strands of DNA. While telomerase was known to address the leading-strand problem, it turns out another molecular complex, CST-Polα-primase, tackles the lagging-strand issue. The leading-strand problem arises because the DNA replication machinery fails to fully duplicate the telomere, leaving it with a blunt leading end. Telomerase adds repeats to solve this issue. However, Hiro Takai's discovery revealed a surprising lagging-strand problem: the replisome cannot fully synthesize the lagging strand, leading to further telomere shortening. Joseph T. P. Yeeles' in vitro experiments confirmed this, showing that the replisome stops lagging-strand synthesis before reaching the 5' end. This revelation challenges previous models of telomere replication and necessitates a reevaluation of our understanding of telomere biology. Takai's subsequent in vivo assays further confirmed these findings, shedding light on how CST-Polα-primase replenishes repeats to maintain telomere integrity. This newfound understanding not only revises textbooks but also holds clinical significance. Mutations in CST-Polα-primase are associated with telomere disorders like Coats plus syndrome. By unraveling the intricacies of telomere maintenance, this research opens doors for potential therapeutic interventions in addressing these devastating disorders. In essence, this study marks a significant step forward in our comprehension of telomere biology, highlighting the complexity of DNA replication and its implications for human health. #TelomereBiology #DNAReplication #MedicalResearch 🧬✨
Did you know that #glycolipids are the “silent architects” that enable complex cellular communication and recognition? These molecules are often overlooked in favor of their "more famous lipid relatives," yet they are vitally important for cell growth and vitality. Let’s take a moment to appreciate and understand the hidden complexities of #glycolipids and the impact they have on our lives. Keep reading our latest blog to find out more! https://ow.ly/6rQn50Q8cKl
Did you know that #glycolipids are the “silent architects” that enable complex cellular communication and recognition? These molecules are often overlooked in favor of their "more famous lipid relatives," yet they are vitally important for cell growth and vitality. Let’s take a moment to appreciate and understand the hidden complexities of #glycolipids and the impact they have on our lives. Keep reading our latest blog to find out more! https://ow.ly/mJzg50Q6vmo
It's been a couple of years since my first independent research experience in the Bayne lab at The University of Edinburgh, but I could not be more proud to see the results we've achieved published in the Journal of Cell Science this month! Here, we discuss a novel mechanism of epigenetic regulation of centromere function in fission yeast. Hopefully the first of many publications to come! #epigenetics #yeast