Computomics’ Post

It’s “Make Sense of Science” time ⏲️
 Today, we’re taking a look at #CoCoPred, an innovative tool developed by our colleague Friederike Lüdtke 🥳 CoCoPred uses machine learning to predict optimal codon usage for organisms, boosting protein production by analyzing the context of surrounding amino acids. This innovation could benefit medicine, agriculture, and industrial applications by enabling more efficient protein synthesis in organisms like bacteria and yeast 🧬🧫 Here's how 👉 https://lnkd.in/d8ZtRnDp #MakeSenseOfScience #ProteinSynthesis #MachineLearning #CodonOptimization #Biotechnology

As we explored in the previous post, microorganisms 🦠 develop defenses to survive in the environment. As they form colonies, they create complex matrices that ensure, among other things, their survival and habitat. These polymeric networks, built by microorganisms through their metabolism, are pivotal for sustainability. At Nat4Bio 🍋, we harness microbiology to study various microbial polymers, which we then use to develop our coatings. This allows us to create a technology that does not produce negative effluents, does not use harsh chemicals that harm the environment, and does not require large amounts of natural resources💧. Leveraging our deep expertise in microbiology and materials science, Nat4Bio coatings are produced naturally and with a focus on circular economy, without genetic modificated organisms, and with no cells in the final products. #Coatings #MicrobialPolymers #Microbiology

In the second installment of a two-part series, 2017-2018 IFT President and author Cindy Stewart, PhD, CFS, IFT Fellow, discusses innovative ways of meeting global protein demands and sustainable food production—specifically through advancements in fermentation and cell culture technologies. Precision fermentation to create specific proteins and ingredients and cultivated meat can positively impact several Sustainable Development Goals (SDGs) including Zero Hunger, Good Health, and Responsible Consumption. Alternative proteins can reduce environmental impact and promote economic growth. Read more about the workforce needs, potential challenges, and future outlook of these innovative technologies: https://hubs.la/Q02ZF3kg0 #FoodTech #PrecisionFermentation #CultivatedMeat #FoodProduction

📢 Revolutionary Method Boosts Plant Hormone Production! 🌱 Researchers have found a way to produce elusive plant hormones called strigolactones using microbial cell factories. 🔬 Collaborating with various universities, they demonstrated the method’s efficiency and scaled up production significantly, over 125 times higher than previous techniques. 🌳 This innovation reduces reliance on natural sources, preserving plants and enabling better study of these vital hormones for plant development. #BioprocessUpdates #MicrobialCellFactories #PlantHormones #Strigolactones #SustainableScience #Biotechnology #PlantDevelopment #ResearchInnovation #EcoFriendly #ScienceCollaboration #HormoneProduction #GreenTechnology #NatureConservation #AgriculturalResearch #ScalableSolutions #PlantScience ▷ Read the full article here: 📎 https://lnkd.in/dZge9h-b

Microbes: The Tiny Powerhouses of Science Sometimes, science just leaves me in awe. Think about this—microbes, these tiny, unseen organisms, have been shaping our world for centuries. They gave us fermentation, antibiotics, and now, they’re changing how we produce food. The fact that we can now make real dairy without cows using precision fermentation blows my mind! Companies like Perfect Day Remilk and Imagindairy are using microbes to produce milk proteins identical to what’s found in traditional dairy. Same taste, same nutrition—just a fraction of the environmental impact. And when I look back, this journey of microbiology has been nothing short of incredible. From penicillin in 1928 to genetic engineering in the 1970s, and now synthetic biology, we’ve come so far. Microbes aren’t just something we study—they’re helping us reshape industries, improve health, and build a more sustainable future. What’s next in the world of microbes? I’m looking forward to seeing where science takes us next! If you’re working on an innovation or know of a startup pushing boundaries in microbiology, drop it in the comments—I’d love to hear about it! #Biotechnology #Microbiology #PrecisionFermentation #FutureOfFood #Innovation #Startups #ScienceForGood

✅ MIT Engineers Boost Microbe Resilience for Extreme Conditions. ✅ . 🌟MIT researchers have developed a method to make microbes resilient enough to withstand extreme conditions, ideal for various applications. 🧬The method uses food and drug additives classified by the FDA as "generally regarded as safe" to stabilize different microbes. 🦠The study focuses on four types of microbes: Escherichia coli Nissle 1917, Ensifer meliloti, Lactobacillus plantarum, and Saccharomyces boulardii. 🚀Some of these microbes were sent to the International Space Station to test their resilience under extreme conditions. 🌡️The stabilized microbes can withstand temperatures up to 50 degrees Celsius without losing functionality. 🏆After exposure to harsh conditions, the microbes maintained their beneficial functions, such as nitrogen fixation and inhibiting harmful bacteria. 🌱Ensifer meliloti, which helps in plant growth by fixing nitrogen, remained effective even after high-temperature exposure. 🦠They also found that their formulation of E. coli Nissle 1917 was able to inhibit the growth of Shigella flexneri, one of the leading causes of diarrhea-associated deaths in low- and middle-income countries, when the microbes were grown together in a lab dish. 🌐The resilient microbes could be used in space missions, human health, and agriculture, showcasing broad applicability. 🔬The microbes underwent extensive stress tests, including shipping, preflight validation, and storage without temperature control. . Source: https://lnkd.in/gZ9wgNUS . #microbiology #biotechnology #news #happening

We are excited to share more about how Sticta Biologicals is leading this transformative project "Unraveling the Metabolic Landscape of Porcine cells: A Genome-scale Modeling Approach" in collaboration with Meatable, Merken Biotech, and the CMM - Center for Mathematical Modeling. In this project we’re developing a genome-scale metabolic model of porcine cells that will:   🔬 Predict the most efficient ways to nourish porcine cells for maximum growth and yield. 🔬 Boost cell line expansion while minimizing variability in production. 🔬 Innovate media solutions, leveraging critical metabolites for enhanced cellular growth. We integrate cutting-edge tools such as mathematical modeling, synthetic biology, bioinformatic and bioprocess engineering to develop a groundbreaking genome-scale metabolic model of porcine cells.   At Sticta, we are at the forefront of biotech solutions, delivering essential growth factors and recombinant proteins, to the global cultivated meat industry. Our mission is to accelerate the commercialization of sustainable, affordable cultivated meat by helping companies achieve price parity with conventional meat.   We're excited about the progress made so far and remain committed to pushing the boundaries of what’s possible in sustainable food technology. A big thank you to our partners and the The Good Food Institute for supporting this vital research.   Stay tuned for more updates as we embark on this exciting journey toward a more sustainable food future! 🌱   Together, we're pushing the boundaries of sustainable food technology! 🌍 #StictaBiologicals #CultivatedMeat #SustainableFood #Biotechnology #GoodFoodInnovation #AlternativeProteins #FutureOfFood #CellularAgriculture #PrecisionFermentation #SynBio Eduardo Agosin Andres Ariztia Elliot Swartz

We start Monday with the next update in our talent series for Swan Neck Bio. People are just as important as technology to help #deeptech companies grow. Michela Winters is a member of our science team and brings experience in food microbiology from the Universities of Cambridge and Melbourne. Please do connect with her on Linkedin regarding your questions on challenges in scaling and outsourcing the seed train. Her Linkedin profile is in the first comment! 🚀 💥 👏 (Please click on the image to expand the text) #innovation #fermentation #biosolutions #bioeconomy #foodtech #deeptech

The success rate of micropropagation is affected by various factors, and one of them is the employment of good lab practices. So, here are Esco's 5 tips to prevent plant tissue culture contamination. May you harvest the fruits of your efforts! Learn more here: https://lnkd.in/gddK9mQj #PlantScience #TissueCulture #Biotechnology #LabSafety #Research #LaminarFlowCabinet #LabEquipment #PlantBiotechnology #Micropropagation #QualityControl

🔍 𝐔𝐧𝐥𝐨𝐜𝐤𝐢𝐧𝐠 𝐍𝐚𝐭𝐮𝐫𝐞'𝐬 𝐄𝐧𝐳𝐲𝐦𝐞 𝐓𝐫𝐞𝐚𝐬𝐮𝐫𝐞 𝐂𝐡𝐞𝐬𝐭: 𝐄𝐱𝐩𝐥𝐨𝐫𝐢𝐧𝐠 𝐜-𝐋𝐄𝐜𝐭𝐚'𝐬 𝐄𝐧𝐳𝐲𝐦𝐞 𝐄𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐢𝐧𝐠 𝐓𝐞𝐜𝐡𝐧𝐨𝐥𝐨𝐠𝐲 🌱 Discovering the right enzymes is at the heart of c-LEcta's innovative enzyme engineering technology. With an abundance of microorganisms in nature, even the smallest environmental samples can yield valuable candidates for developing enzyme products. Dr Rico Czaja, Head of Enzyme Discovery and Bioprospecting, emphasizes the diverse sources of these microorganisms, from soil to extreme locations like the Arctic and hot springs. c-LEcta's treasure trove boasts around 10,000 strains from various biotopes, showcasing a rich portfolio of enzymes. Environmental samples, including those from unexpected sources like baby diapers and contaminated industrial soil, are analyzed to extract the genetic information of microorganisms. This genetic treasure, known as the metagenome, is then translated into enzymes through special production bacteria, creating libraries that are stored at -150°C for future screening. Read full article here: https://lnkd.in/eY-My_Ym This post is part of a series on our 20𝐭𝐡 𝐛𝐢𝐫𝐭𝐡𝐝𝐚𝐲 this year, in which we look behind the scenes.  #EnzymeEngineering #Biotechnology #Innovation