NET CONNECT’s Post

Exploring the link between extracellular vesicle and Cardiovascular diseases progression: Suresh Kumar Verma and collaborators at University of Alabama at Birmingham aimed to demonstrate that pro-fibrotic miRNAs, enriched in small extracellular vesicles derived from IL-10 knockout fibroblasts, promote cardiac fibrosis in pressure-overloaded myocardium https://lnkd.in/eschUKRS Their work revealed that inflammatory fibroblast-derived small extracellular vesicles exacerbate cardiac fibrosis through the miR-21a-5p/ITGAV/Col1α signaling pathway, highlighting miR-21a-5p as a potential therapeutic target for treating hypertrophic cardiac remodeling and heart failure. An article co-authored by Prabhat Ranjan, Roshan kumar dutta, Karen Colin, Jing Li, Qinkun Zhang, Hind Lal and Gangjian Qin #extracellularvesicles #exosomes #cardiacfibrosis #miRNA #Vesiculab

Wait-what? It's cardiomyopathy awareness month! Chemotherapy over 20 years ago irreversibly damaged my heart muscle leaving me with a diagnosis of dilated cardiomyopathy. 5 years ago I progressed into heart failure. There is no cure. It is the leading reason why people require heart transplants. It can happen for many reasons and it affects 1 in 250 people worldwide. The signs and symptoms can be subtle. It is often under diagnosed, misdiagnosed, or diagnosed too late. The consequences of cardiomyopathy can be very serious (including sudden death). Think cardiomyopathy! #cardiomyopathyawareness #dilatedcardiomyopathy

🫀 #Hypertrophic Cardiomyopathy (#HMCH) is the most common genetic heart disease: it affects 1 in 500 people. It is characterized by thickening of the heart muscle, making it more difficult for the heart to contract and pump blood effectively. 🩸 One of the possible complications is obstruction of blood flow, which we know as Hypertrophic Obstructive Cardiomyopathy (#HOCM). 🧬 Identifying the genetic component of the pathology facilitates its early diagnosis and allows proactive decisions that improve its approach and management. 🙌🏻 We've joined Global Heart Hub to raise awareness of #MCH and support #patients. Get informed and... Think #Cardiomyopathy and think fast! 🤔 🔗 https://lnkd.in/dxPGFEYn #ThinkCardiomyopathy #CardiomyopathyAwareness2024 #Cardiomyopathy2024 #ThinkCM #BMSIberia #BMSPortugal #BMSCommunity #BMSTransformingLives #WorkingTogetherforPatients #BMSTransformingPatientsLives SAMS Asociación Asociación Española de Miocardiopatía Hipertrófica (#AEMCH) #Cardioalianza Fundación Española del Corazón  

Global Heart Hub is delighted to today launch our 2024 Cardiomyopathy Awareness Campaign, #ThinkCardiomyopathy! Led by GHH’s Cardiomyopathy Patient Council, which has 24 patient organisation affiliates across 15 countries, the campaign this year focuses on patient and advocate stories on the impact of #cardiomyopathy and the importance of recognising symptoms and knowing your family history. Cardiomyopathy is a disease of the heart muscle that can occur at any age and can be passed down genetically. It affects around 1 in every 250 people worldwide, is an important cause of heart failure and the leading reason for needing a heart transplant. Often underdiagnosed, misdiagnosed, or diagnosed too late, the consequences of cardiomyopathy can be very serious. If untreated, cardiomyopathy can weaken the heart, leading complications and to more serious conditions. Learn more: https://lnkd.in/guw_9fGE #ThinkCardiomyopathy #CardiomyopathyAwareness #Cardiomyopathy2024 #ThinkCM

In our effort to study AI-derived histological features of epithelial injury and repair in Ulcerative Colitis biopsies, we noted that marked loss of goblet cell mucin was correlated with disease activity. Significant increases in the area proportion of goblet cell mucin in crypts were found in cases of histological remission, whether all crypts, inflamed crypts, or only normal crypts were included! https://lnkd.in/eiWP-HSj

Interleukin-6 (IL-6) is a powerful cytokine involved in a wide range of immune responses and is crucial in the body's defense mechanisms. While essential for our health, excessive levels of IL-6 have been linked to the pathology of numerous diseases, including autoimmune, inflammatory, and cardiovascular diseases. Given its central role in inflammation and disease progression, targeting IL-6 offers a promising avenue for developing new treatments that may significantly improve outcomes for patients with life-altering immune and inflammatory diseases. Learn more about how we are targeting IL-6 with our lead candidate, TOUR006: https://bit.ly/45ZVnNf    #biotechnology #eyehealth #drugdevelopment 

Thyroid eye disease (TED) is a complex autoimmune disorder where the immune system mistakenly attacks the tissues around the eyes, causing swelling, bulging, and pain.  Advances in our understanding of TED's pathogenesis have identified that inflammatory pathways are at the core of the disease, leading to research into novel therapies that offer the potential for better patient outcomes. Learn more about our lead candidate, TOUR006, and how it’s targeting underlying inflammatory pathways and being investigated as a potential new way to treat thyroid eye disease:  https://bit.ly/4eD5Ku1  #biotechnology #eyehealth #drugdevelopment 

Kidney Cancer Prevention In many cases, the cause of kidney cancer is not known, in other cases (inherited conditions), even when the cause is known it may not be preventable. But there are some ways you may be able to reduce your risk. - Stop smoking. - Maintain a healthy weight with regular exercise. - Choosing a diet high in fruits and vegetables may also reduce your chance of getting this disease. Learn more about Advanced Urology Associates kidney cancer diagnosis and treatment. https://lnkd.in/eM676NH #kidneycancer #KidneyCancerAwarenessMonth #AUA #cancerawareness #cancerprevention #kidneytreatment

Check out the NACE On-Demand Course: Deep Dive into Five – Answering Your Questions about HoFH. Homozygous familial hypercholesterolemia (FH) is a rare but critical genetic disorder characterized by extremely high LDL cholesterol levels, significantly increasing the risk of early cardiovascular disease. In this activity, Dr. Zahid Ahmad and Dr. Don Wilson provide expert insights into homozygous FH, answering questions from recent live-virtual symposia. They cover crucial topics, including diagnosis, pediatric lipid screening, genetic testing, and care coordination. The experts emphasize the significance of specialized care and early intervention for individuals with homozygous FH, aiming to better inform healthcare professionals and improve patient outcomes. Click here to start the course: https://bit.ly/3QI6vHd #NACE #OnDemand #PatientOutcomes

📢 WEBINAR ALERT! 📌 Save The Date for ‘The Practical Use of CMV inSIGHT (CMV T Cell Immunity Testing) in the LUNG Transplant Recipient.’ Presented by Christina Doligalski, PharmD, of the University of North Carolina. UNC Health REGISTER NOW 👇 📅 March 27th, 12-1pm CST Topics covered include: • Discuss current clinical conundrums with CMV Prevention and Treatment • Utilizing the CMV inSIGHT T cell Immunity Panel (TCIP) • Highlighting clinical scenarios for TCIP guidance • Q&A Session #pharmd #pulmonology #ISHLT #ISHLT24