Curonix’s Post

#TestYourKnowledge 🤔 Comment your answer or find the answer in Lessons From the Lab - Episode 11 - Peripheral Neuropathy: https://ow.ly/LgaF50RgBg7 #AANEM #LessonsFromtheLab #Neuromuscular #NeuromuscularMedicine #EDX #NMDs

We are pleased to announce the publication of a multicenter double-blind randomized, placebo-controlled trial of individuals experiencing moderate-to-severe postoperative pain following knee replacement and treatment with the SPRINT PNS System. The study, published in International Neuromodulation Society's Neuromodulation Journal, highlights the results from the prospective trial evaluating the impact of 60-day peripheral nerve stimulation (PNS) used for chronic knee pain after total knee arthroplasty (TKA). Full story: https://lnkd.in/g375CB6n Cc: David M. Dickerson, MD and Josh Boggs, PhD. Results may vary. Important safety & risk information: https://bit.ly/2FU92NH

Advancing Pain Research with Translational Pig Models. Pigs share many similarities with humans, including skin innervation, wound healing, and neurological characteristics. These similarities drive clinical significance and pave the way for cutting-edge methods, advanced surgical procedures, and relevant administration routes. Learn more about why pigs are a favorable translational model. https://hubs.la/Q02kPYd80 #translationalresearch #painresearch #drugdevelopment #drugdiscovery #translationalmodels

🔍 𝐍𝐞𝐰 𝐈𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐨𝐧 𝐎𝐩𝐭𝐢𝐜 𝐃𝐢𝐬𝐜 𝐃𝐫𝐮𝐬𝐞𝐧 (𝐎𝐃𝐃) Despite being identified over 150 years ago and affecting an estimated 145 million individuals globally, Optic Disc Drusen (ODD) remains a largely enigmatic neurodegenerative optic nerve disorder without a known cure. Historically overshadowed by similar conditions like glaucoma, recent research now highlights the significant clinical relevance of ODD 🌍 🔬 A decade of intensive studies has shown that ODD can lead to substantial visual field defects and severe ischemic complications potentially causing irreversible vision loss. This underscores the critical need for dedicated treatments targeting this disorder 👓 📚 Our latest review, published in Eye (Nature), sheds light on the distinctive calcified nature of ODD. The article delves deep into the pathogenesis, historical treatment attempts, and the role of calcification in ODD. We also address the challenges of developing effective therapies focused on this aspect, should calcification prove to be a key pathogenic factor 🧠👀 Many congrats to Josephine Mejdahl Bentin, MD for writing her first paper, and thanks to my other co-authors Prof. Steffen Heegaard, Prof. Niklas Rye Jørgensen, A/Prof. Louise Grahnemo for your hard work putting this piece together 🙏 (unfortunately the paper is not open access) #opticdiscdrusen https://lnkd.in/dB9TT99K

Last week, at the IASP 2024 World Congress on Pain, we presented the effects of our lead asset, PIPE-791, a novel LPA1R antagonist, on brain activation in a nonhuman primate model of peripheral neuropathy. Our findings showed that PIPE-791 significantly reduced activation in brain regions associated with pain perception, suggesting that blocking LPA1 may be a promising approach to treating neuropathic pain. Learn more here: https://lnkd.in/gxMrxqEy #IASP #pain

Stroke is one of the leading causes of death and disability worldwide, affecting millions every year – but a newly developed molecule could help alleviate stroke-related brain injury. For decades, researchers have tried to develop drugs that can block N-methyl-Daspartate receptors (NMDARs) and prevent the neurotoxicity that comes with the elevated levels of glutamate that occur during stroke. But, because NMDARs play an important role in regular brain functions, these attempts have been largely ineffective.  Now, an international study published in Nature Portfolio reveals a never-before seen glutamate binding site and showcases a molecule that can selectively block glutamate, but leave NMDARs intact – paving the way for a new approach to preventing stroke-related brain injury. Read more about the study co-led by Dr. Lu-Yang Wang, a Senior Scientist at #SKReseach, and clinician scientists at the Shanghai Jiao Tong University School of Medicine ➡️ https://bit.ly/45Wh80h 

🧠 The Importance of MRI in Diagnosing Neurovascular Conflict in Trigeminal Neuralgia 🧠 Trigeminal neuralgia (TN) is a condition that can cause severe, stabbing facial pain, often triggered by everyday stimuli. One of the most common findings in TN is neurovascular conflict, where a blood vessel compresses the trigeminal nerve. Identifying this conflict and grading it is crucial for accurate diagnosis and effective treatment. MRI, particularly high-resolution sequences like FIESTA/CISS, play a vital role in visualising the relationship between the trigeminal nerve and surrounding blood vessels. 🔍 At NeuroReview, we recently received requests to review MRI scans from two patients with suspected trigeminal neuralgia. Our goal? To confirm the presence of neurovascular conflict and provide these patients and their doctors with the insights needed for optimal care. Our commitment to accuracy and expert opinion ensures that every patient receives the attention and clarity they deserve. If you or someone you know is struggling with facial pain and seeking answers, don't hesitate to reach out for a review. Your path to better care starts with a clearer diagnosis. #NeuroReview #TrigeminalNeuralgia #MRI #NeurovascularConflict #ExpertOpinion #BetterDiagnosisBetterCare

New Case! “Surgical Removal of a Migrated WATCHMAN Device" by Andrew G. Saleeb, MD; Juan M. Farina, MD; Asher Jenkins, MD; Rawan Zeineddine, MD; Kenan Shawwaf, MD; Eric H. Yang, MD; Said Alsidawi, MD; Dawn E. Jaroszewski, MD, MBA, FAC; & Francis X. Downey, MD. The WATCHMAN™ atrial appendage closure device is designed to reduce the risk of stroke in patients with nonvalvular atrial fibrillation who are not suitable candidates for long-term oral anticoagulation therapy. However, the device also carries small risks, including procedural complications such as device migration, embolization, or pericardial effusion. We describe a case of WATCHMAN device migration requiring surgical retrieval. Videos & images at Methodist DeBakey Cardiovascular Journal https://lnkd.in/gEqxPUD7

Is exosome therapy the new frontier in aesthetic medicine? 🌟 This groundbreaking approach is quickly gaining attention for its potential in tissue regeneration, wound healing, and treating neurological and autoimmune diseases. With the ability to cross biological barriers like the blood-brain barrier, exosomes could revolutionise personalised medicine by serving as precise diagnostic tools and effective drug delivery systems. 💉✨ Follow https://lnkd.in/g7KzH_T7 to read the complete article at #aestheticmedicalpractitionermagazine.⁠ ⁠ #aestheticmedicine #aestheticmedicinenews #aestheticmedicalpractitioner #cosmeticsurgery #plasticsurgery ⁠#ExosomeTherapy #AestheticMedicine #RegenerativeMedicine #MedicalInnovation #FutureOfBeauty ⁠

Scientists at the Texas Heart Institute have successfully implanted a titanium heart in a groundbreaking artificial heart transplant. This titanium-constructed biventricular rotary blood pump features a magnetically levitated rotor, eliminating friction and significantly reducing wear and tear, thereby extending its lifespan. The heart can pump blood at a rate of 12 liters per minute, sufficient for adult needs, and is designed for patients awaiting permanent heart transplants. Developed by BiVACOR, this technology has been in progress since 2013 and represents a significant advancement in treating end-stage heart failure. The success of this procedure is attributed to the courage of the first patient and the dedication of the medical team involved. #ArtificialHeart #TitaniumHeart #TexasHeartInstitute #HeartTransplant #MedicalBreakthrough #BiVACOR #MaglevTechnology #EndStageHeartFailure #HealthInnovation #ClinicalTrial Read More below: https://lnkd.in/eCx85Hzr