Demos Bio Consulting’s Post

🔍 Join Gyros Protein Technologies for an informative webinar providing insights into the pivotal role of #PeptideSynthesis in modern #DrugDevelopment. 💡 Learn about designing robust syntheses to enhance the SAR process and the interdisciplinary information crucial for successful SAR design. 🌟 Featured speaker, Will Blackwell, will emphasize the importance of chemical flexibility for creative design and thorough investigation in SAR studies. Practical examples will illustrate how to optimize an initial peptide of interest into a quality lead molecule, showcasing how peptide synthesis design and application can impact the drug development process. 🔗 Learn more + register here: https://buff.ly/4be8NWD #DrugDiscovery #DrugCandidate #Peptides #MedicinalChemistry #TherapeuticPeptidePurification #SolidPhasePeptideSynthesis

Innovation That Drives Breakthroughs | Agilent https://lnkd.in/gG5GfZEc More in-depth data about sequence, structure, modifications, and purity can help you make better decisions about your candidate molecules. The new Agilent ExD cell with the Agilent ExDViewer analysis software easily and cost-effectively adds electron capture dissociation (ECD) to the capabilities of the 6545XT AdvanceBio LC/Q-TOF. So, you can elevate your peptide and protein analyses and minimize costly delays in your research. #biosimilars #biopharma #PTM #glycopeptides #topdownMS #peptides

A new invention from big pharma Merck, which reports the invention of MK-7845, a novel reversible covalent 3CLPro inhibitor. While most covalent inhibitors of SARS-CoV-2 3CLPro reported to date contain an amide as a Gln mimic at P1, MK-7845 bears a difluorobutyl substituent at this position. SAR analysis and X-ray crystallographic studies indicate that this group interacts with His163, the same residue that forms a hydrogen bond with the amide substituents typically found at P1. In addition to promising in vivo efficacy and an acceptable projected human dose with unboosted pharmacokinetics, MK-7845 exhibits favorable properties for both solubility and absorption that may be attributable to the unusual difluorobutyl substituent. #Merck #MK-7845 #Inhibitors #Glutamine #SARS #3CLPro #Peptides #Proteins #Medchem #DrugDiscorvery #CDMO #FFS https://lnkd.in/gVtcagyc

🔍 Join Gyros Protein Technologies for an informative webinar providing insights into the pivotal role of #PeptideSynthesis in modern #DrugDevelopment. 💡 Learn about designing robust syntheses to enhance the SAR process and the interdisciplinary information crucial for successful SAR design. 🔗 Learn more + register here: https://buff.ly/4be8NWD Featured speaker: Will Blackwell #DrugDiscovery #DrugCandidate #Peptides #MedicinalChemistry #TherapeuticPeptidePurification #SolidPhasePeptideSynthesis

⭐️The excitement is great and preparations are ongoing - the #IOPC2024 will be a very special event. This is why... 🔄The peptide therapeutics landscape is changing dramatically. Not only due to the success of obesity treatments with GLP-1 analogs, but also due to fading boundaries to other modalities like oligonucleotides. The associated challenges for synthesis, in particular, are immense and, in order for us to help overcome them, conferences like IOPC are fundamental to engage with the scientists and understand their needs. 👨🔬 👩🔬 💡We have prepared for this event with a set of new application data and we are happy to share this in advance: https://lnkd.in/dyrPC82T 📍Please meet our team including Luísa Aguiar and Silvia Marini at booth #16 to discuss your project and how PurePep solutions can help you innovate for a better life. #purepep #oligonucleotide #peptides #synthesis #purification

𝐀𝐜𝐜𝐞𝐥𝐞𝐫𝐚𝐭𝐞 𝐏𝐞𝐩𝐭𝐢𝐝𝐞 𝐃𝐫𝐮𝐠 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭. No matter whether you are doing 𝐩𝐫𝐞-𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐩𝐞𝐩𝐭𝐢𝐝𝐞 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡 or are conducting 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐭𝐫𝐢𝐚𝐥𝐬, when it comes to peptides, we are unbeatable in Expertise, Quality and Speed.   Want to learn more? Book a meeting or send an email via the link in comment. 𝐏𝐞𝐩𝐭𝐢𝐝𝐞𝐬 𝐓𝐚𝐢𝐥𝐨𝐫𝐞𝐝 𝐭𝐨 𝐘𝐨𝐮𝐫 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐌𝐚𝐧𝐮𝐟𝐚𝐜𝐭𝐮𝐫𝐞𝐝 𝐰𝐢𝐭𝐡 𝐄𝐱𝐜𝐞𝐥𝐥𝐞𝐧𝐜𝐞. #PeptideExperts #PeptideManufacturing #PeptideDrugDevelopment

Interaction of a new triazole compound with serum albumins and bromelain... Application of fluorescence in drug discovery... #medicinalchemistry #drugdesign #docking #synthesis #fluorescence #proteins

Less immunogenic #LNP composition by replacing the PEG–lipid ALC-0159 with DMG-PEG2k. The paper evaluated 4 different LNP formulations, their CQAs, physical characterization, stability, in-vitro and in-vivo protein n expression.  

Piperazine and 1-azabicyclo[2.2.2]octane are both present in a new drug candidate CRN04894. To expand future studies, we have created two sets of analogs to those fragments, which can be solid starting points for your research projects: -Piperazine derivates set ( https://buff.ly/3URMSyD ) -Azabicyclooctane derivates set ( https://buff.ly/3WqFqga ) CRN04894 is a strong and subtype-specific first-in-class nonpeptide MC2R that has shown efficacy in a rat model of adrenocorticotropic hormone (ACTH)-stimulated corticosterone secretion. CRN04894 is now being tested in a first-in-disease Phase Ib/IIa trial in people with ACTH-dependent Cushing's syndrome, as well as a Phase II trial in people with congenital adrenal hyperplasia. Sounds interesting? drop us a line at info@chem-space.com #chemspace #openscience #research #science #drugdiscovery #chemicals #medicinalchemistry #drugdevelopment #chemistry #researchanddevelopment #search #chemicalindustry #science #structures

𝐖𝐞’𝐫𝐞 𝐠𝐢𝐯𝐢𝐧𝐠 𝐚𝐰𝐚𝐲 𝐨𝐧𝐞 𝐟𝐫𝐞𝐞 𝐚𝐧𝐭𝐢𝐛𝐨𝐝𝐲 𝐜𝐡𝐚𝐫𝐚𝐜𝐭𝐞𝐫𝐢𝐳𝐚𝐭𝐢𝐨𝐧 𝐬𝐞𝐫𝐯𝐢𝐜𝐞 𝐭𝐨 𝐨𝐮𝐫 𝐟𝐨𝐥𝐥𝐨𝐰𝐞𝐫𝐬! Why? We’ve launched new LC-MS services and we want the world to know: ➡ Peptide Mapping ➡ Glycan analysis ➡ Disulfide bond analysis ➡ Intact mass analysis and more! 𝐖𝐡𝐚𝐭 𝐲𝐨𝐮 𝐰𝐢𝐧: One of the above LC-MS characterization services for an antibody. See promotion details here: https://lnkd.in/gZ3CTHkr 𝐇𝐨𝐰 𝐭𝐨 𝐰𝐢𝐧:  1. Follow Rapid Novor on LinkedIn 2. “Like” and “Share” this post to your feed! 3. Stay tuned for the announcement on July 31 #AntibodyCharacterization #AntibodyDevelopment