Intavis Peptide Services’ Post

🔍 Join Gyros Protein Technologies for an informative webinar providing insights into the pivotal role of #PeptideSynthesis in modern #DrugDevelopment. 💡 Learn about designing robust syntheses to enhance the SAR process and the interdisciplinary information crucial for successful SAR design. 🔗 Learn more + register here: https://buff.ly/4be8NWD Featured speaker: Will Blackwell #DrugDiscovery #DrugCandidate #Peptides #MedicinalChemistry #TherapeuticPeptidePurification #SolidPhasePeptideSynthesis

https://buff.ly/3ZaVuE4 🧬 𝐁𝐢𝐨𝐠𝐞𝐧 𝐑𝐞𝐩𝐨𝐫𝐭𝐬 𝐏𝐨𝐬𝐢𝐭𝐢𝐯𝐞 𝐏𝐡𝐚𝐬𝐞 2/3 𝐃𝐚𝐭𝐚 𝐟𝐨𝐫 𝐇𝐢𝐠𝐡𝐞𝐫-𝐃𝐨𝐬𝐞 𝐒𝐩𝐢𝐧𝐫𝐚𝐳𝐚 𝐢𝐧 𝐒𝐌𝐀 🧬 Biogen announced positive topline results from the Phase 2/3 DEVOTE study evaluating a higher-dose regimen of Spinraza (nusinersen) in infantile-onset spinal muscular atrophy (SMA). The primary endpoint, change from baseline in CHOP INTEND score at 6 months, demonstrated a statistically significant improvement compared to a historical control group (p<0.0001). The higher-dose regimen consists of two 50 mg loading doses followed by 28 mg maintenance doses every 4 months, compared to the currently approved 12 mg regimen. While detailed safety and efficacy data will be presented at a future medical conference, Biogen reported a lower percentage of serious adverse events in the higher-dose group. Based on these results, Biogen plans to seek FDA approval for the higher-dose regimen, potentially offering a new treatment option for SMA patients. #Biogen #Spinraza #SMA #RareDisease #Biotech #ClinicalTrial #FDA #Nusinersen

Let's revisit a modern “classic in drug discovery” and a lesson that nothing is impossible in the #small_molecule R&D: Macrocyclic PCSK9 protein-protein interaction (PPI) inhibitor, MK-0616, is a once-daily #PCSK9-lowering and #LDL_cholesterol-lowering small molecule that has recently demonstrated antibody-like efficacy as an oral agent in the clinic. Origins of the compound here: https://lnkd.in/eqXdj8Fh

📢 Attention researchers! Invitrogen™ Vivofectamine™ Delivery Solutions have arrived to revolutionize in vivo delivery of nucleic acids with lipid nanoparticles (LNPs)! With their outstanding versatility and safety profile, Vivofectamine products are the ideal choice for both basic researchers and therapeutic development. But that's not all – we also offer custom products and services for supporting therapeutic development. From start to finish, our Vivofectamine Delivery Solutions can provide the delivery system you need for success. Don't miss out on the opportunity to enhance your research, accelerate your project timelines and take it to the next level. Check out Vivofectamine now and unlock new possibilities! 🔗 https://lnkd.in/e3cd5Mrk #delivery #lipidnanoparticles #nucleicacidmedicine #mrnavaccine #mrnatherapeutics #vivofectamine #LNP

Unlocking #mRNA-#LNP potential using a novel lipid library combined with innovative #analyticalmethods #Lipidnanoparticles (LNPs) have seen success in their use for #RNAdelivery in various therapies. However, LNPs still exhibit limitations including a tendency to accumulate in the liver and strict requirements for post-formulation quality monitoring. Addressing these challenges holds the key to unlocking the full therapeutic potential of these innovative treatments. Next month, Polyplus now part of Sartorius’ Guillaume Freund (Process Technology Manager) and Sartorius BIA Separations’ Nejc Pavlin (Process Analytics Development Manager) will discuss novel strategies for mRNA-LNP development such as a library of imidazolium-based lipids and liquid #chromatography to ensure the quality, efficacy, and safety of LNPs in various applications. Register for this upcoming #webinar below:

Understanding the metabolic fate of a potential drug candidate is crucial, yet recognizing how Metabolite Identification (Met ID) can benefit the discovery program at different stages can be limited. Our latest blog, by expert Iain Beattie, delves into the benefits of Met ID at various stages of molecule development. Explore Key Insights: ➡ The importance of metabolic stability in early drug discovery, especially for PROTACs. ➡ Bring consideration of metabolic profile in human into lead optimization. Discover how Met ID can drive your projects forward, offering detailed metabolic profiles and enabling smarter design decisions. Read the Full Blog Here: https://lnkd.in/ezTH3YYj #dmpk #adme #metabolites #drugdiscovery

We invite you to read a very interesting post written by our MetID expert Iain Beattie. Share with us any thoughts or questions you may have. #DMPK #MetID #CharnwoodDiscovery #Drugdiscovery

⭐️The excitement is great and preparations are ongoing - the #IOPC2024 will be a very special event. This is why... 🔄The peptide therapeutics landscape is changing dramatically. Not only due to the success of obesity treatments with GLP-1 analogs, but also due to fading boundaries to other modalities like oligonucleotides. The associated challenges for synthesis, in particular, are immense and, in order for us to help overcome them, conferences like IOPC are fundamental to engage with the scientists and understand their needs. 👨🔬 👩🔬 💡We have prepared for this event with a set of new application data and we are happy to share this in advance: https://lnkd.in/dyrPC82T 📍Please meet our team including Luísa Aguiar and Silvia Marini at booth #16 to discuss your project and how PurePep solutions can help you innovate for a better life. #purepep #oligonucleotide #peptides #synthesis #purification

Catch our latest on-demand webinar to find out why Optimer binders are the ideal affinity reagent for small molecule analytes. Offering high selectivity with convenient in-solution detection and quantification, it might be just the solution you need. https://bit.ly/3vMl59K #aptamers #smallmolecule #drugdevelopment

🔍 Join Gyros Protein Technologies for an informative webinar providing insights into the pivotal role of #PeptideSynthesis in modern #DrugDevelopment. 💡 Learn about designing robust syntheses to enhance the SAR process and the interdisciplinary information crucial for successful SAR design. 🌟 Featured speaker, Will Blackwell, will emphasize the importance of chemical flexibility for creative design and thorough investigation in SAR studies. Practical examples will illustrate how to optimize an initial peptide of interest into a quality lead molecule, showcasing how peptide synthesis design and application can impact the drug development process. 🔗 Learn more + register here: https://buff.ly/4be8NWD #DrugDiscovery #DrugCandidate #Peptides #MedicinalChemistry #TherapeuticPeptidePurification #SolidPhasePeptideSynthesis