Discovery Life Sciences’ Post

📣 ICYMI, Here is the on-demand recording of our latest Golden Helix, Inc. webinar: Introducing VSPGx: Pharmacogenomics Testing in VarSeq 💊🧬: https://lnkd.in/esTWahQ6

Interesting white paper on the use of Physiologix™ as a Serum Replacement Supplement to Promote the Growth and Performance of Primary T Cells – In this white paper, they review a comprehensive study designed to compare the performance of Physiologix to human serum as a supplement to support T cell growth, expansion, and viability while increasing transduction efficiency. Identifying a T cell culture media that can maximize cell performance and seamlessly transition from development to commercialization is complex. Physiologix is a GMP and xeno-free serum replacement that can drive desirable critical quality attributes at superior levels to FBS and human serum. As an alternative to serum, Physiologix also helps avoid regulatory hurdles and optimizes development. https://lnkd.in/g3cihKxj

Looking forward to talking GPCRs, strategies for identifying new targets in the tumor microenvironment and learning more about how allosteric modulators have fared in the clinic. #GPCRdrugdiscovery #GPCRsinCancer

As the IVD industry continues to evolve, new regulations frequently come into place to better control an innovative and growing industry. Molecular IVDs in particular are experiencing tighter regulations regarding the presence of appropriate controls within the assay. All tests must include both positive and negative controls which are subjected to the whole testing process, including the extraction step. Novel co-extracted exogenous controls are providing cutting edge solutions for monitoring RNA or DNA analysis including the detection of potential inhibition. These controls can be used across a variety of sample types and assays, representing a significant advantage over traditional spike-in controls. Learn more by watching our webinar on “Novel Solutions for Improved Process Control in Your Molecular IVD Assays”. Click here: https://hubs.la/Q02dssbz0

Hope to see you all at #AACR2024 next week! Come check out a poster by our collaborator, Light Chain Biosciences, to see their exciting work including the use of modeling and simulation to support therapeutic development. Poster #5293: "Preclinical development of NI-3201, a PD-L1xCD28 bispecific antibody mediating CD28 costimulation upon PD-L1 blockade" #AACR, #QSP, #MID3, #Modeling, #PKPD, #Bispecifics, #Immunooncology

Discover the significance of plasmid DNA, updates in regulatory guidelines for your therapeutic projects, and success stories in accelerating ATMP development. Join Dr. Andrew Frazer for a concise 30-minute case study webinar. Watch here: https://okt.to/Oq4ICG #plasmiddna #genet

Antibody-drug conjugates (ADCs) stand out as innovative biotherapeutics, but understanding their ADME properties during the discovery and development stages can be complex. This upcoming webinar can help! Join us on March 20th from 11:15 to 11:45 am, EST, as we share insights and strategies for ADC development at AAPS’s eCHALK webinar (free registration: https://hubs.li/Q02p6cnG0). Topics include: ✅ Payload release mechanisms ✅ Identification of catabolites in various in vitro systems ✅ Detection of drug–antibody ratios (DAR) ✅ The implementation of an integrated bioanalysis platform catering to both small and large molecules #aapscomms #adc #drugdiscovery #drugdesign #bioanalytical #dmpk #adme

Looking for high-quality, custom proteomic assays to support your clinical trial success? 🤔 We’ve got you covered. CellCarta offers a full range of validated proteomics assays, with sites accredited by CAP and CLIA certified to ensure the highest quality standards. What’s more, our experts are on hand to ensure you get a bespoke, validated assay that meets your exacting requirements. Assays include: ⭐MSD single plex ⭐MSD multiplex ⭐Olink panels ⭐ELISA Discover the full list here👇 #Biomarkers #ClinicalTrials #PrecisionMedicine #Proteomics

As JP Morgan Healthcare Conference for 2024 ends, a hot topic has been #ADCs and #precisionmedicines. If you are looking for the next precision targeting molecule for development in the ADC, #radioligand, or #genetherapy space, come and talk to us about #Optimer.    Optimers are oligo-based antibody alternatives with small size for rapid tissue penetration, tuneable kinetics for optimized target vs. systemic exposure, and high affinity and selectivity for precision-targeted cargo.    Compatible with diverse linkers and giving controlled chemistry for accurate drug loading, come and talk to us if you are seeking new solutions to support your pipeline.  https://lnkd.in/eS9-YTHZ

ADC development is complex, involving challenges from target selection to linker stability. At Sino Biological, we specialize in tailored solutions to simplify your journey. Our catalog includes ADC target proteins, MMPs, Cathepsins, and uPA for linker cleavage studies. Essential for PK and ADA assays, we offer high-quality anti-idiotypic antibodies, Fc receptors, and anti-payload antibodies. Our CRO services span early discovery to clinical research, providing comprehensive support for your ADC project's success. Discover how we can elevate your ADC development process: https://ow.ly/u2wJ50SqbHj #ADCDevelopment #AntibodyDrugConjugate #AntibodyDevelopment