DTU Biotech Lifelong Learning’s Post

MEETING | Future Trends in Biocatalysis, Abstract deadline 15.01.2025 IBPRO2025 26th - 28th of March 2025 Aarhus Denmark https://lnkd.in/eS4TP3hB 📢 Register here 👉 https://lnkd.in/erSzMh_5 🔎 Discovery the preliminary program 👉 https://lnkd.in/eyib_M7s   Early bird prolonged to December 31st Abstract deadline January 15th Session 1: Enzyme discovery and design for industrial applications Session 2: Heterogenization of biocatalysts with tailor-made materials Session 3: Intensification of heterogenized bioprocesses: from solvent design towards flow biocatalysis Session 4: Out-of-the-box methods: Future trends in biocatalysis Overall, the ultimate goal of the conference is to create a multidisciplinary atmosphere stimulating the exchange of knowledge between participants and identifying potential collaborations between research groups from industry and academia. IBPRO2025 will be a hybrid symposium. While the attendance is limited to 200 in-person attendees, for the best possible networking experience, it is open to additional attendees for the scientific lectures in an online form.

🔬 Excited to Share Our Latest Publication! 🔬 As a BioEngineer, it was incredible to dive deep into enzyme engineering, optimizing our split trehalase enzyme for a more efficient biosensor platform. This paper is the latest in our lab’s ongoing work to harness trehalase activity, which generates glucose, as a biosensing tool for clinical applications. Special thanks to my former technician, YONGPENG FU, whose talent and dedication made this project a success! Our study focused on addressing two key challenges: optimizing the pH for trehalase function in blood and enhancing activity through hybrid enzyme engineering. By combining fragments from distantly related organisms (Cellvibrio spp. and E. coli), we created hybrids with improved stability and activity in near-physiological conditions—enabling practical, point-of-care applications. Check out the full paper for insights into how we’re pushing the boundaries of enzyme engineering for diagnostics! https://lnkd.in/gXH3VzpR BioEngineering #Diagnostics #EnzymeEngineering #Biosensors #Innovation

🚨 Join Our Exclusive Webinar! 🚨 Wednesday, 26th February 2025 | 45 minutes We’re thrilled to partner with Constant Systems Limited to bring you an insightful session featuring Dr. Lindsay McDermott, Senior Lecturer in Biochemistry at the University of Bedfordshire. What You’ll Gain: 🔸 Expert Insights: Discover Dr. McDermott’s groundbreaking research on ZAG protein, including its role in obesity and cachexia, and the first-ever crystal structure of ZAG bound to a lipid ligand (featured in the Biochemical Journal). 🔸 Technology in Action: See a live demo of Constant Systems’ revolutionary high-pressure cell disruption platform. 🔸 Interactive Q&A: Get your questions answered by industry experts Matthew Wright, Riaan Fox, and Jay Champaneri. Why Attend? Learn how high-pressure cell disruption technology is revolutionizing bioprocessing workflows across academia and industry. Register now to reserve your spot: https://lnkd.in/ew427KqS Don’t miss this opportunity to stay ahead in bioprocessing innovation! #Webinar #Bioprocessing #CellDisruption #Biotechnology #Innovation #Biochemistry #HighPressureTechnology #LabTech #ResearchInnovation #AcademicResearch #BiotechIndustry #ConstantSystems #BPES

🧬 𝗥𝗲𝗽𝗼𝗿𝘁𝗶𝗻𝗴 𝗳𝗿𝗼𝗺 𝘁𝗵𝗲 𝗦𝘆𝗻𝘁𝗵𝗲𝘁𝗶𝗰 𝗮𝗻𝗱 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿𝗶𝗻𝗴 𝗕𝗶𝗼𝗹𝗼𝗴𝘆 𝗕𝗿𝗶𝘁𝗶𝘀𝗵-𝗦𝘄𝗶𝘀𝘀 𝗦𝘂𝗺𝗺𝗶𝘁 𝗶𝗻 𝗕𝗿𝗶𝘀𝘁𝗼𝗹 Our CSO, Dr. Frank Plöger, was participating as a panelist at the prestigious Synthetic and Engineering Biology British-Swiss Summit in Bristol. This summit is a collaborative initiative, bringing together academic and industry leaders from the UK and Switzerland to explore cutting-edge developments in synthetic and engineering biology. During the session on Bioprocessing and Scale-Up, Frank and fellow experts delved into critical topics, including: 🔹 How rapid advancements in synthetic and engineering biology are expanding the possibilities of bioprocess technologies in the healthcare space. 🔹 Current challenges in bioprocessing concerning new modalities and the complexities of reproducibility and standards/metrology. 🔹 Scale-up challenges from an investment perspective. 🔹 Educating and collaborating with relevant communities, including academics, to address knowledge and skills gaps in bioprocessing and scale-up. We are thrilled to contribute to these important discussions and look forward to continuing our efforts in bridging the gap between research and development in the life sciences. Special thanks to Anike Te from Lucideon for the invitation 👏 Tim Heinemann Oliver Dovey Helen Stubbs Pugin #SyntheticBiology #EngineeringBiology #Bioprocessing #HealthcareInnovation #Biotechnology #LifeSciences #Innovation #Investment

𝟯️⃣ [ 𝗧𝗛𝗘 𝗩𝗛𝗛 𝗧𝗢𝗢𝗟𝗕𝗢𝗫 ] 𝗨𝗻𝗹𝗼𝗰𝗸𝗶𝗻𝗴 𝗻𝗲𝘄 𝗶𝗻𝘀𝗶𝗴𝗵𝘁𝘀 𝗶𝗻 𝗧𝗮𝘂 𝗳𝗼𝗹𝗱𝗶𝗻𝗴 𝗮𝗻𝗱 𝘀𝘁𝗿𝘂𝗰𝘁𝘂𝗿𝗮𝗹 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗼𝘂𝗿 𝗡𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀®🔬    Our 𝗩𝗛𝗛 𝗧𝗼𝗼𝗹𝗯𝗼𝘅 continues to push boundaries in the field of Tau research! This spring, our synthetic nanobodies were highlighted in the Journal of Biological Chemistry (April 2024). The study from Isabelle Landrieu’s lab and collaborators explores how these nanobodies provide crucial insights into Tau folding, structural dynamics, and activity relationships. ➡️ 𝗪𝗵𝗮𝘁’𝘀 𝗡𝗲𝘅𝘁? We’re excited to share that more VHHs are in development! Clément DANIS and Elian Dupre, with the support of our PhD network European Network TauImmune, are working on new anti-Tau nanobodies that will further expand the capabilities of our toolbox.  𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝗼𝘂𝗿 𝗶𝗻𝗻𝗼𝘃𝗮𝘁𝗶𝗼𝗻𝘀 𝗮𝗻𝗱 𝘀𝗲𝗲 𝗵𝗼𝘄 𝗼𝘂𝗿 𝗰𝘂𝘁𝘁𝗶𝗻𝗴-𝗲𝗱𝗴𝗲 𝗻𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀 𝗰𝗮𝗻 𝗯𝗼𝗼𝘀𝘁 𝘆𝗼𝘂𝗿 𝗽𝗿𝗼𝗷𝗲𝗰𝘁 ! 🔗 https://lnkd.in/eKYNXnDv #Innovation #Biotechnology #Nanobodies #Tau #ScientificResearch #HybrigenicsServices #SyntheticNanobodies #TauResearch 

🚀 Exciting news! My first paper has been published! 🎉 The paper, titled "Tools to investigate oxygen-related challenges with flavin-dependent enzymes," has been published in the Archives of Biochemistry and Biophysics as a part of the special issue "Current Topics in Flavins and Flavoproteins" proceedings of the 21st International Symposium on Flavins and Flavoproteins held in 2024 in Atlanta, GE, where I presented my work in an oral presentation. 🎤 This work explores one of the key challenges that arise when using oxygen as the oxidizing agent in biocatalysis. In industry, and in the lab, we encounter what we call "the oxygen dilemma": while large amounts of oxygen must be supplied continuously into the reactor to keep up the desired reaction rate, the presence of a gas-liquid interface has a huge detrimental effect on the stability of the enymes. ⚡ In our review, we present two complementary systems to study this challenge: one which keeps the gas-liquid interface constant and is useful to study enzyme stability, and another which mainains the oxygen partial pressure constant (without the presence of gas-liquid interface) which is useful to study enzyme kinetics. 🧪 We also want to higlight the importance of collaboration across disciplines (from industrial biocatalysis to biochemistry and enzyme engineering) to make significant progress toward achieving economically feasible biocatalytic processes that can be implemented in industry. 🤝💡 I’m thrilled to contribute to this area of research, and I look forward to seeing how these tools can help address key challenges in enzyme-based oxidative catalysis. I would like to thank my team in DTU Chemical and Biochemical Engineering and my supervisors John Woodley and Elif Erdem their contribution to the paper and support. 🙏 📋 Find the full paper in Archives of Biochemistry and Biophysics to learn more about these findings and their potential impact on industrial applications. 👉 https://lnkd.in/dp7Kuu58 #Research #Biocatalysis #OxygenChallenges #Oxidases #Flavoenzymes #EnzymeKinetics #EnzymeStability #OxygenTransfer #GasLiquidInterface #IndustrialApplications #AcademicAchievement

Register and Participate in the ASSB Knowledge Sharing Webinar Series 2.0 👇👇 It's going to be super interesting as the discussion will delve into the basics and fundamentals of synthetic biology.

Great advancements using machine learning and mass spectroscopy.

제 연구의 처음과 마지막을 네이처 시리즈로 마무리 할 수 있어 크나큰 영광입니다 (lnkd.in/gtTKxF9C) 기초과학연구원과 하버드 MGH의 연구진, 그리고 네이처 에디팅 팀에 깊은 감사를 표합니다. I am honored to have my research journey begin and culminate with the Nature series. I recently published my first-author paper in Nature Reviews Bioengineering, focusing on the lab-to-market strategy for molecular diagnostic platforms. You can find the most recent version here: rdcu.be/dNbj7 This review paper provides practical insights for experts on developing molecular diagnostics platforms using nanomaterials, from the initial development stages to commercialization. It comprehensively covers the physical and chemical properties of target-specific materials, FDA approvals, medical and environmental regulations, and ISO certification, offering real-world solutions for commercial viability. This may very well be my final scientific paper. I extend my heartfelt gratitude to the Institute for Basic Science and Harvard MGH professors for their support, and to the Nature publishing team for their tireless efforts and countless revisions to ensure a successful publication.

Excited to share our latest research in ACS Applied Bio Materials. Check out our paper