DTU Bioengineering

Engagerede studerende er en kæmpe drivkraft for DTU - Technical University of Denmark 💪🏻 I går afholdt DTU Åbent Hus og det var en nem dag for Martin Dufva og jeg at være studieledere dermed have ansvaret for at bemande standen og holde rundvisning for hhv. Bioteknologi og Teknisk Biomedicin. Vi havde nemlig >20 studerende, der frivilligt havde arrangeret det hele og dagen igennem svarede på hundredevis af spørgsmål fra de besøgende 🥳 Tusind tak for indsatsen til jer alle sammen! Nu håber vi blot på at se mange af de besøgende igen til studiestarten sidst i august 👏🏻 📸 Marie Bentzon (de flotte) og undertegnede (de andre) ☺️

🎉 Congratulations to PhD student Jakob Woessmann on receiving an Elite Research Travel Grant! This marks the fourth time a researcher from DTU Bioengineering has been awarded this prestigious grant, following in the footsteps of Line Ledsgaard, Camilla Reiter Elbæk, and Aleksander Moldt Haack. Jakob’s research focuses on single-cell proteomics—using mass spectrometry to quantify low-abundance proteins in individual blood cells. By mapping the unique protein landscapes of single cells, he aims to deepen our understanding of the human blood system and how cancer can develop in immature blood cells. The Elite Research Travel Grant will allow Jakob to collaborate with leading researchers in the USA and Europe, advancing his expertise in mass spectrometry-based proteomics and single-cell data integration. Congratulations again, Jakob! 👏 #EliteForsk #DTUBioengineering #Proteomics #MassSpectrometry #SingleCellBiology

"Recent advances in proteomics are having a profound impact on biomanufacturing. The rapid developments in mass spectrometry (MS) equipment and techniques are unlocking new ways to ensure the safety and efficacy of biopharmaceutical products," says Marie Vestergaard Lukassen, Manager of the DTU Proteomics Core at DTU Bioengineering. “At the DTU Proteomics Core, we strive to stay at the forefront of these exciting advancements in mass spectrometry technology. We support research groups across DTU and external clients by offering cutting-edge mass spectrometry workflows. From seaweed to ants—if it contains proteins, we can measure it. Operating at the intersection of biology, physics, chemistry, and robotics, the ever-evolving equipment continues to push the boundaries of what is measurable, making this an incredibly fascinating field to be a part of.” 👉 Explore the DTU Proteomics Core: https://lnkd.in/dNjmFNpS Marie is currently developing video modules for a new online course, Applied Mass Spectrometry for Biomanufacturing, offered by Biotech Lifelong Learning. This course is designed to provide participants with a foundation in the principles and applications of mass spectrometry in biopharmaceutical analysis. It highlights the analytical value of MS in quality control for protein therapeutics and equips learners with the tools and knowledge to transition conventional assays into MS-based workflows. "The module I'm working on focuses on host cell protein (HCP) identification," Marie explains.  "Biotherapeutics are often produced using engineered cells, which also express host cell proteins unrelated to the intended therapeutic product. These HCPs can impact the quality, stability, and safety of the final product. This module will guide participants through the essential steps and considerations for performing this LC-MS-based assay. Using bottom-up mass spectrometry, you can ensure the safety and efficacy of your biopharmaceutical products." Launching in Spring 2025, this course is a collaboration between DTU Biotech Lifelong Learning and NC State BTEC. Delivered through short, engaging videos—known as "BTEC Shorts"—the course embraces the growing trend of microlearning to offer accessible and efficient education. #Proteomics #Pharmaceuticals #LifelongLearning #Biomanufacturing #MassSpectrometry

🏆 Congratulations to Professor Andreas Laustsen-Kiel on receiving a Elite Research Award! 🏆 We are incredibly proud that Andreas Hougaard Laustsen-Kiel, Professor at DTU Bioengineering, has been recognized as one of this year’s recipients of the prestigious Elite Research Award from the Ministry of Higher Education and Science. The award is presented today by Her Majesty Queen Mary and Minister for Higher Education and Science Christina Egelund. Andreas is a world leader in modern antivenom research, pioneering biotechnological methods to develop next-generation antidotes and broad-spectrum antibody therapies. His work is shaping the future of biotechnology and medicine, with applications ranging from neutralizing snake venoms to fighting antibiotic-resistant bacteria. Since becoming a professor at just 35 years old, Andreas has demonstrated an extraordinary ability to bridge cutting-edge research with real-world impact. He has filed 14 patents, co-founded eight biotech companies, and contributed to over 100 new products—a testament to his dedication to translating science into practical and commercial solutions. This is also a proud moment for DTU Bioengineering, as we celebrate our second researcher receiving the Elite Research Award - the first being Alexander K. Buell who received the award in 2023.  Please join us in celebrating Andreas Hougaard Laustsen-Kiel for this well-deserved honor! 🎉 Read more and watch a video with Andreas on DTU.dk: https://lnkd.in/dt5riimg Independent Research Fund Denmark #EliteResearchAward #DTUBioengineering #AntibodyTechnology #Biotechnology #ResearchExcellence

🔬 Tackling One of Life Science’s Key Challenge: Design and Optimization of Biologics 🤖 Exciting news! Novo Nordisk and DTU - Technical University of Denmark are launching a cross-disciplinary research program to harness the power of AI-driven Closed-Loop technology to design and optimize biologics, which is one of the life science industry’s key challenges. This partnership allows us to collaboratively engage in cutting edge scientific research generating tangible real-world impact for both DTU and Novo Nordisk. By integrating closed-loop optimization technology with AI-driven binder design, we aim to automate the discovery and optimization of novel binders, expediting the process while minimizing labor. The initiative will build on the recent advances in protein design, automation, and multi-parameter optimization and create a closed loop pipeline able to rapidly design binders to any target and optimize them for developability. This is made possible through DTU’s Corporate Partnership model, which fosters deep, long-term strategic collaboration between academia and industry and combined with Novo Nordisk expertise in biologics design, ambition to drive interdisciplinary innovation in drug discovery and development and develop multi-lingual scientists with objective of enhancing the lives of individuals living with serious chronic conditions. Keep an eye out for upcoming job postings—we’ll soon be recruiting both postdocs and PhD students to join this exciting journey. https://lnkd.in/d-riEzyW https://lnkd.in/dK45r6-Z We would like to thank the DTU and Novo Nordisk team who make this project possible: DTU: Timothy Jenkins, Line Clemmensen, Carolina Barra, Rasmus John Normand Frandsen, Lazaros Nalpantidis, Anne Ljungars, Elena Papaleo, Esperanza Rivera de Torre and Xinxin Zhang Novo Nordisk: Andreas Hald, Paolo Marcatili, Søren Bertelsen, Jesper Ferkinghoff-Borg, Diana Miszczuk, James Love, Allan Christian Shaw and Thomas E. Nielsen #Innovation #LifeScience #Automation #DTU #NovoNordisk

𝟭𝟬 𝗦𝗘𝗖𝗢𝗡𝗗𝗦 𝗧𝗢 𝗦𝗔𝗩𝗘 𝗔 𝗟𝗜𝗙𝗘 - 𝘌𝘯𝘨𝘪𝘯𝘦𝘦𝘳𝘴 𝘢𝘯𝘥 𝘥𝘰𝘤𝘵𝘰𝘳𝘴 𝘶𝘯𝘪𝘵𝘦 𝘵𝘰 𝘳𝘦𝘷𝘰𝘭𝘶𝘵𝘪𝘰𝘯𝘪𝘴𝘦 𝘤𝘳𝘪𝘵𝘪𝘤𝘢𝘭 𝘤𝘢𝘳𝘦 Imagine this: in just 10 seconds, a single drop of blood could determine life-saving treatment for critically ill patients. ADRENALINE SHOT - OR NOT A shot of adrenaline is standard treatment when a patient is in critical shock due to trauma, sepsis or cardiac arrest. But for hundreds of Danish patients a year, this is the wrong treatment. If the body is in shock and, therefore, already has critically high levels of adrenaline in the blood, this shot could send the heart into overdrive and increase the risk of death. THE POWER OF INTERDISCIPLINARY COLLABORATION Professor in transfusion medicine Pär Johansson from Rigshospitalet has found that if you measure the content of so-called succinic acid in the blood, you can use it as a biomarker for patients with a more severe reaction to shock. Professor in Bioengineering Winnie E. Svendsen from DTU has utilised this knowledge to develop a new rapid test - based on nanostructures. The speciality of the test lies in the layers applied to the electronic circuit that reacts to succinic acid. The layers are nano-sized, larger than single atoms, but still very small compared to particles we can see with the naked eye. LARGER SENSOR SURFACE MEANS A QUICKER ANSWER The nanostructures have the quality of expanding the sensor surface in the test because the blood droplet doesn't just slide across a flat surface but is instead sent up and down a much larger surface of nanostructures that rise vertically on the sensor surface. This is also why doctors can get the crucial answer so quickly. The goal is for the test to deliver an answer within 10 seconds on a reader - and the researchers are even looking at a Bluetooth solution that can send the result to a mobile phone. Photos: Bax Lindhardt #DTUdk #TechnologyForPeople #Engineering #Biotechnology #HealthTech #Innovation

Congratulations to Head of ‘Data Science Hub' Timothy Jenkins on his new additional role as Research Group Leader at the 'Center for Antibody Technologies' at DTU Bioengineering. With a mission to leverage modern technology and drive innovation in biotechnology for societal benefit, Tim's research group, 'Digital Biotechnology Lab', focuses on harnessing the power of AI, data science, and automation to explore protein-protein interactions, particularly in antibody and binder discovery. The group's work includes developing innovative de novo peptide sequencing solutions and engineering binding proteins for applications in diagnostics, therapeutics, and bioindustrial processes. Their research aims to address challenges such as cancer, viral infections, and toxin neutralization. Visit the research group website: https://lnkd.in/dgR8K7uT

Two researchers from DTU - Technical University of Denmark have been appointed Council Chairs in Independent Research Fund Denmark's Research Councils. From 1 January 2025 Professor Susanne Brix Pedersen is chair for the Technology and Production Sciences Research Council (FTP), and Associate Professor Kirstine Berg-Sorensen is Chair for the Natural Sciences research council (FNU). "I look forward to leading the Council for Technology and Production Sciences (FTP) and collaborating with council members to support groundbreaking research and technological innovation. I am eager to share our progress with the public and grateful for the trust placed in me in this important role", says Susanne Brix Pedersen. Congratulations to both professors on this well-deserved recognition. Read more here: https://lnkd.in/dd7i8sq2 #ResearchLeadership #InnovationInScience #ResearchFunding #NaturalSciences (Photos by Claus Lillevang for the Independent Research Fund Denmark)

Researchers have created new proteins that neutralise lethal toxins found in snake venom. This can potentially offer a safer and more effective alternative to traditional antivenoms. Every year, snakebites affect millions globally, causing over 100,000 deaths and countless disabilities. Traditional antivenoms, while life-saving, are costly, have limited efficacy, and often come with severe side effects. But now, groundbreaking research led by the 2024 Nobel Laureate in Chemistry David Baker (University of Washington) and Timothy Jenkins (DTU) shows that by using AI-driven protein design, you can develop new proteins that neutralise deadly toxins. "I believe protein design will help make snake bite treatments more accessible for people in developing countries," said Susana Vazquez Torres, lead author of the study and a researcher in Baker's lab at the Institute for Protein Design at UW Medicine. Preclinical trials have achieved an 80-100% survival rate in mice - depending on the exact dose, toxin and designed protein. 𝗪𝗵𝘆 𝘁𝗵𝗶𝘀 𝗺𝗮𝘁𝘁𝗲𝗿𝘀: • The proteins are cost-effective in producing and bypassing the need for traditional animal-derived methods. • These tiny, AI-designed molecules penetrate tissues better and act faster than existing treatments. • A completely computer-driven discovery process dramatically reduces development time and costs. DTU's Associate Professor Timothy Patrick Jenkins highlights the potential: "The most remarkable result is the impressive neurotoxin protection they afforded mice. However, one added benefit of these designed proteins is that they are so small that we expect them to penetrate tissue better and potentially neutralise toxins faster than current antibodies. And because the proteins were created entirely on the computer using AI-powered software, we dramatically cut the time spent in the discovery phase." While traditional antivenoms remain essential, this innovative approach could transform healthcare in resource-limited regions and pave the way for tackling other diseases. #DTUdk #TechnologyForPeople #Engineering #Biotechnology #SnakeVenom #HealthTech #Innovation

🔬🍷 Mikroorganismer – sidste nyt fra forskningsfronten Kom og hør Lone Gram, når hun præsenterer den nyeste viden om, hvordan bakterier producerer antibiotika – og hvordan denne indsigt kan bane vejen for at opdage nye antibiotika. Dette foregår i regi af Natural History Museum Denmark's meget populære foredragsrække "Vin & Videnskab". 📅 ONSDAG 14.05.2025 kl. 19.00–21.15 Billetsalget starter onsdag den 22. kl. 18 OBS: Billetterne bliver ofte udsolgt efter få timer 👉 https://lnkd.in/da4F4SCN Mikroorganismerne er usynlige for det blotte øje, men de spiller en afgørende rolle for vores sundhed, miljø og fremtid. Aftenen giver et indblik i deres fascinerende verden. Også på programmet: 📢 Ditlev E. Brodersen fra Aarhus Universitet deler sit teams banebrydende forskning i at vende bakteriers immunsystemer mod dem selv som en løsning på antibiotikaresistens. 📢 Ida Hartvig, adjunkt og botaniker, afslører, hvordan planternes mikrobiomer spiller en central rolle for bæredygtigt landbrug og sunde økosystemer. 📢 Mads Albertsen, professor og forskningsleder, fortæller om sit projekt Microflora Danica, der kortlægger Danmarks mikrober og giver ny viden til bæredygtige løsninger for klima og landbrug. Læs mere om aftenen: https://lnkd.in/dbYMqUtb