Elizabeth Daly’s Post

3D Printing Elevates Canada’s Healthcare and Pharma Industry 3D printing is rapidly advancing the healthcare and pharmaceutical industries in Canada, providing innovative solutions that are revolutionizing patient care. The technology’s ability to create customized medications and medical devices is offering new levels of precision and personalization, transforming the way healthcare is delivered. In Canada, the 3D printing market within healthcare is projected to grow by over 20% annually, with the global healthcare 3D printing market expected to reach $6 billion by 2026. This growth is being driven by the demand for personalized medicine, more efficient drug production, and innovative medical devices. Pharmacies and pharmaceutical companies are leveraging 3D printing to produce tailored medications. This allows for the creation of personalized dosages, shapes, and sizes, offering a significant improvement over mass-produced drug. Studies show that 3D-printed medications can improve patient compliance by as much as 50%, particularly for patients who struggle with conventional pills due to size or taste. Canada’s medical device sector is also benefiting from 3D printing, which enables the creation of patient-specific prosthetics, implants, and surgical tools. For example, 3D-printed surgical models help reduce operation time by 25%, improving patient outcomes and lowering healthcare costs. The technology also speeds up the production of complex devices, with prototypes created in days rather than months. The flexibility of 3D printing is particularly beneficial for remote and underserved areas. Canadian hospitals can use 3D printers to produce essential medical supplies on-demand, reducing the need for costly inventory and transportation. This is especially valuable for producing items with short shelf lives or specific requirements, such as customized implants. As 3D printing continues to evolve, its impact on Canada’s healthcare and pharmaceutical industries will only grow, leading to more accessible, efficient, and personalized care for patients across the country. #3DPrinting #HealthcareInnovation #Pharmaceuticals #Canada #MedicalDevices #PersonalizedMedicine #PatientCare #TechInHealth

2024 PHARMACEUTICAL HOT TOPICS: Additive Manufacturing (3D Printing) 💠FOREWORD 💠 Three-dimensional (#3D) printing was discovered in the 1980s, and many industries have embraced it, but the #pharmaceuticalindustry is slow or reluctant to adopt it. The first patent on 3D printing was issued in 1986 to Charles Hull, founder of 3D systems and first commercial 3D printer was available in 1988. The advancements in the pharmaceutical field have accelerated the development of novel active pharmaceutical ingredients (#API), most of which are hydrophobic with low bioavailability and a narrow therapeutic window. The conventional dosage forms that follow the #onesizefitsallrule pose challenges in delivering API's with a narrow therapeutic window. These dosage forms do not consider the #pharmacokineticvariability, especially in pediatric and geriatric patients, often leading to either subtherapeutic action or adverse effects caused by underdose and overdose, respectively. As a result, there is a growing demand for the development of pharmaceutical formulations intended to deliver API within the therapeutic range. ‼️The use of 3D printing helps in formulating the API with a narrow therapeutic index, leading to precise doses. Furthermore, conventional dosage forms' limited drug loading capacity restricts its scope in #longactingformulations. However, the 3D-printed drug-eluting systems can incorporate large quantities of the drug and control the drug release over a period, which has gained attention over the decades. 💠Three-dimensional (3D) printing💠 3D printing, also known as #additivemanufacturing (AM), is a printing technology that builds objects layer by layer, replicating the computer-aided design (#CAD) model. Under supremacy in precision, high drug-loading, and producing complex structures, this technology is highly capable of addressing the limitations associated with conventional dosage forms and producing effective personalized medicines and medical devices. #Stereolithography (#SLA), a vat-photopolymerization technique, that uses a laser beam, is known for its ability to fabricate complex 3D structures ranging from micron-size needles to life-size organs, because of its high resolution, precision, accuracy, and speed. Due to its excellent advantages, this technology could transform the conventional “one dose fits all” concept to bring a #digitalizedpatientcentricmedication into reality. More details in the article cited below https://lnkd.in/dkJ_qF9W 💠 FDA Guidance and Resources💠 Technical Considerations for Additive Manufactured Medical Devices https://lnkd.in/dPrnXQPu If you like this post follow me on LinkedIn

“The National Institute of Standards and Technology just released a paper talking about its trajectory and the need for regulations to ramp up 3D printing for making drugs more accessible, targeted, and in certain cases, flavorful, too... Compared to factories, the biggest advantage of these 3D printers is that they will "produce small batches down to single dose allotments," opening the doors for "personalized precision dosages/therapies for individuals." That means we can not only expect medicines to come in a perfect dosage but also in a chosen shape and preferred flavor, too.” #medical #medicine #additivemanufacturing #3dprinting #research #standards #nist #tech #manufacturing #engineering #medicalengineering

The Rise of 3D Printed Drugs. Imagine being able to take personalized 3D printed tablets tailored for you. Researchers from the Centre for Additive Manufacturing (CfAM) at University of Nottingham used Multi-material Inkjet 3D printing (MM-IJ3DP) to create tablets with a variety of medicines timed to be released a specific times, "enbaling highly customized drug delivery sytems with unparalleled precision." This will also simplify medication regimes and allow for highly personalized medicines for specific patients. Work continues to expand the number of drugs that can be printed. 3Dnatives Centre for Additive Manufacturing (CfAM) at University of Nottingham Yinfeng He University of Nottingham Felicity Rose #3dprinting #3dprinteddrugs #personalizedmecidine #medicine #pharmaceuticals #healthcare #customization #research #futurist #trendforecasting

Innovating the Future of Pharmaceuticals: A New Chapter in 3D Printing and AI Excited to unveil our latest milestone in pharmaceutical innovation: a book chapter titled "3D Printing of Pharmaceutical Products Using AI Technology," published in a prestigious volume accessible here: https://lnkd.in/dP64K8pT. This chapter represents a significant advance in the field, blending AI with 3D Printing (Additive Manufacturing) to redefine what's possible in drug production and personalized medicine. We delve into how this cutting-edge integration overcomes traditional barriers in 3D printing, such as enhancing production speeds, enabling automation, and facilitating the creation of complex, custom-tailored drug formulas. Our collaborative effort sheds light on the untapped potential of AI and Machine Learning to revolutionize pharmaceutical manufacturing, offering a blueprint for future innovations that prioritize efficiency, precision, and patient-specific care. This work not only paves the way for individualized medication solutions but also sets a new standard for the industry, moving us towards a more personalized, patient-centric healthcare model. I have heartfelt gratitude to my co-authors, Anand Kumar S, Sneha Sharma, and Dr Rajkumar Velu, for their unwavering dedication and profound insights. We are proud to contribute to this transformative journey in healthcare technology. #3DPrinting #AIinPharma #AdditiveManufacturing #PharmaceuticalManufacturing #DigitalHealth #InnovationInHealthcare

Revolutionizing Medicine with Our Customized Tablet 3D Printer At Jabi TDD Solutions, we are excited to introduce our pioneering 3D printer designed for the production of customized tablets. This innovative technology represents a significant leap forward in the pharmaceutical and biomedical markets, offering a new way to achieve personalized medicine and on-demand drug release. Our 3D printer is not just a piece of advanced equipment; it's a game-changer for the industry. By leveraging the power of 3D printing, we enable the creation of tablets with tailored dosages, shapes, sizes, and controlled release properties. Whether it’s for a single medication or a polypill containing multiple drugs, our printer allows for precise customization to meet individual patient needs. We've fine-tuned our printer’s technology to ensure optimal drug loading, mechanical characteristics, and drug release behavior. This means that every tablet produced is not only customized in appearance—such as size, shape, and color—but also in its functional properties. Our printer can handle small batch productions, addressing drug shortages and reducing material waste while lowering production costs. The advantages of our 3D printing technology extend beyond customization. Medical professionals can now produce medicines on-demand right at clinics, hospitals, and pharmacies. This capability enhances patient compliance by ensuring that each patient receives the exact medication they need, when they need it. Our technology is designed to support targeted treatments and facilitates the production of medicines with high structural complexity and customer-specific designs. This approach is set to transform conventional drug manufacturing, leading to more efficient and effective healthcare solutions. By incorporating our 3D printer into your practice, you'll be at the forefront of a revolution in medicine—delivering disease-centric and patient-centric treatments with unparalleled precision and efficiency. #3DPrinting #PharmaceuticalInnovation #CustomizedMedicine #HealthcareTech #PatientCare #OnDemandProduction

Jabi TDD Solutions: Redefining Healthcare with 3D Printing At Jabi TDD Solutions, our value proposition lies in delivering personalized and efficient healthcare solutions through innovative 3D printing technology. Our 3D printer allows medical and pharmaceutical professionals to create customized tablets on-demand, offering tailored dosages, physical appearance, and even flavour. By integrating multiple medications into a single pill, we simplify treatment, reducing the need for patients to take multiple pills for different ailments. A key advantage of our technology is its ability to provide controlled drug release. Using a formulation based on high amylose corn starch and alginate, we ensure that our 3D-printed tablets offer precise release behaviour. Alginate’s non-toxic, biocompatible, and biodegradable properties allow for better patient safety and effective drug delivery. By delaying drug release in the stomach and upper intestine for up to four hours, we enhance the overall therapeutic outcome. Our 3D printer also shortens production time. It’s a versatile tool, designed with a smaller footprint and capable of handling small-scale demand. This flexibility allows for rapid, precise manufacturing of customized medications, which is particularly beneficial in addressing niche patient needs or rare conditions. Waste reduction is another core benefit of our technology. The additive nature of 3D printing means that we use only the exact amount of material required for each tablet, minimizing waste. This not only cuts down costs but also supports a more environmentally friendly approach to drug manufacturing. Perhaps one of the most transformative aspects of our solution is decentralized manufacturing. With our 3D printers, hospitals and clinics can produce small batches of drugs on-site, offering just-in-time access to tailored medications. This model ensures easier access to critical medications, addresses shortages, particularly in pediatric drugs, and provides personalized treatments at the point of care. #3DPrinting #PersonalizedMedicine #PharmaceuticalInnovation #HealthcareTech #ControlledRelease #DecentralizedManufacturing #SustainableHealthcare #PatientCare

What if you could encapsulate active pharmaceutical ingredients or cells within a resorbable or dissolvable photopolymer shell? There has been much talk about 3D printing pharmaceuticals and implantable drug-eluting devices. The concept makes perfect sense: Use the geometric freedom of 3D printing combined with the excipient material to control the release rate of a second Active Pharmaceutical Ingredient (API). With some 3D printing technologies, such as material jetting, APIs and excipients can be deposited concurrently, producing complex therapies. However, material jetting presents some problems regarding pressures, temperatures, and API suspicion and distribution. One alternative is to suspend the API in a bioinert fluid, which a 3D-printed shell can then encapsulate. By selecting the right materials for the shell and controlling the shell thickness, new patient-specific solutions and therapies could be developed with highly controllable drug release. However, current 3D printing architecture has prevented this approach from gaining traction. At Rayo3D, we have a new solution for manufacturing resorbable and dissolvable devices. Our technology, which we call InLiq-3D, uses a bioinert hydrogel that can be preloaded with an API. The unique aspect of InLiq-3D technology is that the hydrogel also acts as a support structure for the shell material, which can be deposited using simple material extrusion 3D printing. The finished device or drug-eluting capsule can then be removed from the InLiq-3D material, with any residual InLiq-3D washed away in water.

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of #3Dprinting in pharma, in conversation with Pharma‘s Almanac to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

In this new Q&A on Pharma's Almanac, MilliporeSigma’s Thomas Kipping, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, including applications for creating innovative dosage forms and streamlining the supply of clinical trial material. #pharma #3dprinting #additivemanufacturing #clinicalsupply #osd #pharmaceuticalinnovation