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2024 PHARMACEUTICAL HOT TOPICS: Additive Manufacturing (3D Printing) 💠FOREWORD 💠 Three-dimensional (#3D) printing was discovered in the 1980s, and many industries have embraced it, but the #pharmaceuticalindustry is slow or reluctant to adopt it. The first patent on 3D printing was issued in 1986 to Charles Hull, founder of 3D systems and first commercial 3D printer was available in 1988. The advancements in the pharmaceutical field have accelerated the development of novel active pharmaceutical ingredients (#API), most of which are hydrophobic with low bioavailability and a narrow therapeutic window. The conventional dosage forms that follow the #onesizefitsallrule pose challenges in delivering API's with a narrow therapeutic window. These dosage forms do not consider the #pharmacokineticvariability, especially in pediatric and geriatric patients, often leading to either subtherapeutic action or adverse effects caused by underdose and overdose, respectively. As a result, there is a growing demand for the development of pharmaceutical formulations intended to deliver API within the therapeutic range. ‼️The use of 3D printing helps in formulating the API with a narrow therapeutic index, leading to precise doses. Furthermore, conventional dosage forms' limited drug loading capacity restricts its scope in #longactingformulations. However, the 3D-printed drug-eluting systems can incorporate large quantities of the drug and control the drug release over a period, which has gained attention over the decades. 💠Three-dimensional (3D) printing💠 3D printing, also known as #additivemanufacturing (AM), is a printing technology that builds objects layer by layer, replicating the computer-aided design (#CAD) model. Under supremacy in precision, high drug-loading, and producing complex structures, this technology is highly capable of addressing the limitations associated with conventional dosage forms and producing effective personalized medicines and medical devices. #Stereolithography (#SLA), a vat-photopolymerization technique, that uses a laser beam, is known for its ability to fabricate complex 3D structures ranging from micron-size needles to life-size organs, because of its high resolution, precision, accuracy, and speed. Due to its excellent advantages, this technology could transform the conventional “one dose fits all” concept to bring a #digitalizedpatientcentricmedication into reality. More details in the article cited below https://lnkd.in/dkJ_qF9W 💠 FDA Guidance and Resources💠 Technical Considerations for Additive Manufactured Medical Devices https://lnkd.in/dPrnXQPu If you like this post follow me on LinkedIn

3D printing of pharmaceuticals is the future! We are excited to be a part of it..check out this article to hear from our expert Thomas Kipping about this paradigm-shifting technology https://lnkd.in/ebvd5DzR

Innovating the Future of Pharmaceuticals: A New Chapter in 3D Printing and AI Excited to unveil our latest milestone in pharmaceutical innovation: a book chapter titled "3D Printing of Pharmaceutical Products Using AI Technology," published in a prestigious volume accessible here: https://lnkd.in/dP64K8pT. This chapter represents a significant advance in the field, blending AI with 3D Printing (Additive Manufacturing) to redefine what's possible in drug production and personalized medicine. We delve into how this cutting-edge integration overcomes traditional barriers in 3D printing, such as enhancing production speeds, enabling automation, and facilitating the creation of complex, custom-tailored drug formulas. Our collaborative effort sheds light on the untapped potential of AI and Machine Learning to revolutionize pharmaceutical manufacturing, offering a blueprint for future innovations that prioritize efficiency, precision, and patient-specific care. This work not only paves the way for individualized medication solutions but also sets a new standard for the industry, moving us towards a more personalized, patient-centric healthcare model. I have heartfelt gratitude to my co-authors, Anand Kumar S, Dr. Mitali Pareek, Sneha Sharma, and Dr Rajkumar Velu, for their unwavering dedication and profound insights. We are proud to contribute to this transformative journey in healthcare technology. #3DPrinting #AIinPharma #AdditiveManufacturing #PharmaceuticalManufacturing #DigitalHealth #InnovationInHealthcare

“The National Institute of Standards and Technology just released a paper talking about its trajectory and the need for regulations to ramp up 3D printing for making drugs more accessible, targeted, and in certain cases, flavorful, too... Compared to factories, the biggest advantage of these 3D printers is that they will "produce small batches down to single dose allotments," opening the doors for "personalized precision dosages/therapies for individuals." That means we can not only expect medicines to come in a perfect dosage but also in a chosen shape and preferred flavor, too.” #medical #medicine #additivemanufacturing #3dprinting #research #standards #nist #tech #manufacturing #engineering #medicalengineering

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of #3Dprinting in pharma, in conversation with Pharma‘s Almanac to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

𝟯𝗗 𝗽𝗿𝗶𝗻𝘁𝗶𝗻𝗴 𝗼𝗳 𝗰𝗮𝗿𝘃𝗲𝗱𝗶𝗹𝗼𝗹 𝗼𝗿𝗮𝗹 𝗱𝗼𝘀𝗮𝗴𝗲 𝗳𝗼𝗿𝗺𝘀 𝘂𝘀𝗶𝗻𝗴 𝘀𝗲𝗹𝗲𝗰𝘁𝗶𝘃𝗲 𝗹𝗮𝘀𝗲𝗿 𝘀𝗶𝗻𝘁𝗲𝗿𝗶𝗻𝗴 𝘁𝗲𝗰𝗵𝗻𝗶𝗾𝘂𝗲 The adjustment of the dose according to the individual needs of the patient is a unique advantage of 3D printing technology, which is of particular importance for the pediatric and geriatric population, due to the diverse needs and characteristics of these groups of patients (Kotta et al., 2018). Selective laser sintering (SLS) is one of the newest 3D printing techniques that uses powder materials, where the powder particles are connected under the influence of laser beams. The main disadvantage of SLS 3D printing is the high process temperature, which can lead to the degradation of active substances. On the other hand, this technique has many advantages, such as high resolution, the possibility of powder recycling and the absence of preprocessing (Fina et al., 2018; Thakkar et al., 2021). Continue reading here: https://lnkd.in/dAK8_Vi5 #3dprinting #excipients #pharmaceuticals BASF Pharma Solutions MEGGLE Excipients Evonik Health Care

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, in conversation with Pharma’s Almanac's to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

The Rise of 3D Printed Drugs. Imagine being able to take personalized 3D printed tablets tailored for you. Researchers from the Centre for Additive Manufacturing (CfAM) at University of Nottingham used Multi-material Inkjet 3D printing (MM-IJ3DP) to create tablets with a variety of medicines timed to be released a specific times, "enbaling highly customized drug delivery sytems with unparalleled precision." This will also simplify medication regimes and allow for highly personalized medicines for specific patients. Work continues to expand the number of drugs that can be printed. 3Dnatives Centre for Additive Manufacturing (CfAM) at University of Nottingham Yinfeng He University of Nottingham Felicity Rose #3dprinting #3dprinteddrugs #personalizedmecidine #medicine #pharmaceuticals #healthcare #customization #research #futurist #trendforecasting

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, in conversation with Pharma’s Almanac's to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment

Discover this Q&A, where Thomas Kipping, Ph.D., Head of 3D Printing and Solubility Enhancement, sheds light on the evolution, current state, and future prospects of 3D printing in pharma, in conversation with Pharma’s Almanac's to discuss the topic of additive manufacturing, commonly known as 3D printing, and how it is reshaping pharmaceutical manufacturing. Unlike traditional oral solid dose (OSD) manufacturing, 3D printing offers unparalleled flexibility in designing drug prototypes, final dosage forms enabling precision dosing and the creation of complex release kinetics. This technology is especially valuable during early R&D, for creating innovative dosage forms and streamlining the supply of clinical trial material. Our raw materials portfolio plays a leading role in the 3D printing space, establishing collaborations and developing products to realize the potential of additive manufacturing. #solidformulation #formulation #osd #drugdevelopment