Frank Bernier, PhD, MSc, CIP’s Post

#citation Exciting research breakthrough in #liverhealth ! 🌟The recent research from Southern Medical University delves into the intricate mechanisms of iron metabolism in Nonalcoholic Fatty Liver Disease (NAFLD) and reveals the crucial role of Caveolin-1 (Cav-1). Researchers used specialized mouse models and in vitro experiments to unravel the impact of Cav-1 on liver health. Key takeaways: ✅ NAFLD disrupts lipid and iron metabolism. ✅ Reduced Cav-1 levels worsen iron metabolism in NAFLD. ✅ Cav-1 protects against oxidative stress. ✅ Macrophages with Cav-1 impact iron accumulation. ✅ Cav-1 predicts iron-related changes in NAFLD patients. These groundbreaking insights emphasize the significance of Cav-1 as a target protein in regulating iron and lipid metabolism. It holds promise for predicting and safeguarding against NAFLD development. Read more here: https://lnkd.in/gmpJZHRC Cyagen is proud to be part of this research with our Cav-1ᶠˡᵒˣ/ᶠˡᵒˣ mice. Check out our services here: https://lnkd.in/gjext7gN #knockout #liverdisease #mice #sciencecommunication #research #researchinnovation #researchpaper #biotechnologie #biotech #biotechnology

Syncell is pleased to announce our attendance at the FASEB Molecular Metabolism: Cells and Systems conference. We will be showcasing our research poster titled "Identifying novel peri-droplet-mitochondrial interface proteins of oleic acid-treated HepG2 cells using microscopy-guided subcellular spatial protein purification." This presentation highlights our innovative approach and the capabilities of Microscoop technology in identifying previously unrecognized protein constituents at the mitochondria-LD interface, paving the way for further functional examination associated with lipid regulation and Non-alcoholic fatty liver disease pathogenesis. Connect with our scientist Yen Ming Lin. The conference covers a wide range of important topics, such as emerging methods for analyzing the compartmentalization of metabolism at the cell and tissue levels, the latest advances in regulating metabolic physiology and organ crosstalk, outstanding questions and current areas of research in targeting GLP1, and how metabolites can function as signaling molecules. We look forward to participating in insightful discussions and networking with fellow researchers at the FASEB Molecular Metabolism: Cells and Systems Conference. #Syncell #MolecularMetabolism #FASEB2024 #MMCSRC

Examining systems approaches for utilizing cell culture-derived extracellular vesicles in therapy for acute kidney injury: in this review article, David J. Lundy, Chia-Te Liao at Taipei Medical University and Barbara Szomolay at Cardiff University School of Medicine provided an overview of acute kidney injury syndrome and EV biology, emphasising the technical aspects and therapeutic potential of EVs derived from cell culture https://lnkd.in/ehYvNezQ Subsequently, they demonstrated how multi-omic approaches to analysing the miRNA, protein, and genomic cargo of extracellular vesicles can offer fresh perspectives on their mechanisms of action and help resolve lingering questions in the field #extracellularvesicles #exosomes #systemsbiology #kidneydiseases #miRNA #Vesiculab

Research from our lab and others has provided strong evidence that replication stress plays a pivotal role in eukaryotic chromosome biology and is a driving force in hereditary diseases characterized by genomic instability and features of accelerated aging. Emerging evidence suggests that replication stress can also cause organ and tissue decline associated with normal aging. In our very recently published Communications Biology (Nature) review article, we discuss the latest advances demonstrating how replication stress is an ultimate driver of cellular senescence and aging, highlighting connections to hallmarks of aging and potential avenues for senotherapeutic drug development. #NationalInstituteonAging #NIH #hallmarksofaging #senescence #replicationstress #biomedicalresearch https://lnkd.in/eJqp_WbZ

𝗠𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮 𝗮𝘁 𝘁𝗵𝗲 𝗡𝗲𝘅𝘂𝘀 𝗼𝗳 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗔𝗴𝗶𝗻𝗴, 𝗮𝗻𝗱 𝗗𝗶𝘀𝗲𝗮𝘀𝗲 ⭐ Thus, this new line of research has been published in the medical journal: 𝘍𝘳𝘰𝘯𝘵𝘪𝘦𝘳𝘴 𝘪𝘯 𝘊𝘦𝘭𝘭 𝘢𝘯𝘥 𝘋𝘦𝘷𝘦𝘭𝘰𝑝𝘮𝘦𝘯𝘵𝘢𝘭 𝘉𝘪𝘰𝘭𝘰𝘨𝘺, with surprising advances in the cellular biology of the mitochondria, involved in well-known functions such as cellular respiration, but now understanding its role in pathologies such as: ✅ Ageing ✅ Neurodegeneration ✅ Metabolic disease ✅ Cancer Many years of research have passed since we understood the primary role of mitochondria in the Krebs cycle 💥 for cellular oxygenation to such complex processes, demonstrating how mitochondria contribute to the regulation of nutrient-sensing and signaling pathways. These pathways, for example, when activated, 𝗽𝗿𝗼𝗺𝗼𝘁𝗲 𝗹𝗶𝗳𝗲𝘀𝗽𝗮𝗻 in flies, worms and in mice through controlled diet compositions and timing of food intake. 💯 👏 A great series of scientific articles published about the 𝙢𝙞𝙩𝙤𝙘𝙝𝙤𝙣𝙙𝙧𝙞𝙖, an organelle that only has a diameter of 𝟭 - 𝟮 μ𝗺 and a length of approximately 𝟴 μ𝗺 in the new edition of 𝘍𝘳𝘰𝘯𝘵𝘪𝘦𝘳𝘴 𝘪𝘯 𝘊𝘦𝘭𝘭 𝘢𝘯𝘥 𝘋𝘦𝘷𝘦𝘭𝘰𝑝𝘮𝘦𝘯𝘵𝘢𝘭 𝘉𝘪𝘰𝘭𝘰𝘨𝘺 Series of articles ▶️ https://lnkd.in/evDnfhyx

📢 Review Sharing-Vol. 29 No. 1 💕 Title: Significance of Mitochondrial Dysfunction in the Pathogenesis of Parkinson's Disease 🤵 Authors: Alexander Blagov*, Anton Postnov, Vasily Sukhorukov, Mikhail Popov, Jamol Uzokov, Alexander Orekhov,* 🔔 Full Text: https://lnkd.in/eEPF6aUu 🔑 Keywords: #Parkinson's disease; #neuron; #mitochondria; #mitochondrialdysfunction 😎Welcome to your reading! #Bioscience #biomedicalscience #biochem #medicalscience #ScienceCommunication

𝗖𝗮𝗻 𝗻𝗮𝗻𝗼𝗯𝗼𝗱𝗶𝗲𝘀 𝗻𝗲𝘂𝘁𝗿𝗮𝗹𝗶𝘇𝗲 𝘀𝗻𝗮𝗸𝗲𝗯𝗶𝘁𝗲 𝘃𝗲𝗻𝗼𝗺? Learn more and read the paper here: https://lnkd.in/dWc8FpsW In this 7th paper together, DTU - Technical University of Denmark and Sophion Bioscience have published on nanobodies (the part of an antibody that binds to specific peptides) that can bind and neutralize the key active components found in coral snake venom. Dr. Melisa Benard Valle, PhD & colleagues in professor Andreas Laustsen-Kiel’s lab used a variety of antibody/nanobody discovery techniques to find an oligoclonal mix to bind and neutralize a variety of venom peptide components. Via the Qube 384 nAChR channel recordings, Sophion’s Dr. Kim Boddum showed the venom alpha-neurotoxin neutralizing capacity of these nanobodies. Finally, professor Alejandro Alagon’s lab at Instituto de Biotecnología UNAM showed these nanobodies increased mouse survival rates in envenomation studies. Congratulations to all authors on this Nature Communications paper that takes us another step closer to finding treatments for snakebite, a World Health Organization designated neglected tropical disease. #Toxins #Venom #PhageDisplay #AntiBody #Qube384 #AutomatedPatchClamp #IonChannels #DrugDiscovery #Electrophysiology #Sophion

Dr. Ronald Klatz, MD, DO Worldhealth.net The American Academy of Anti-Aging Medicine (A4M) #antiaging #aging #longevity #antiagingmedicine #antiagingresearch #regenerativemedicine #medicine #worldhealth #health #DNA #clinicalresearch #research #wellness Scientists discovered that certain genes in the Greenland shark are specifically duplicated within a functionally connected network related to DNA repair. This may play a key role in the shark's extreme longevity. https://lnkd.in/gfwBZbZc

AZAFAROS B.V. is thrilled to make two important announcements:  📜8 posters selected for presentation at upcoming international conference on lysosomal storage disorders, the WORLDSymposium™. 📊 Results of the first-in-human Phase 1 study testing the safety in healthy volunteers of our lead asset, nizubaglustat, have been published in leading peer-reviewed journal, Molecular Genetics and Metabolism.   Four posters showing baseline data from our landmark natural history (PRONTO) study in patients with GM1 and GM2 gangliosidoses were among the eight selected for presentation at the WORLDSymposium™, to be held at the Manchester Grand Hyatt Hotel in San Diego from 📅 February 4-9.    Other posters include the design of our Phase 2 RAINBOW study investigating nizubaglustat in patients with GM2 gangliosidosis and Niemann-Pick disease type C (NPC). Additionally, we will present results from a novel human 🧠 brain organoid model of GM1 gangliosidosis in collaboration with the Australian Institute for Bioengineering and Nanotechnology AIBN. Azafaros is proud to present these clinical trial achievements 🎯 as we work closely with investigators, patient advocacy groups and investors towards finding treatment solutions for families and patients with GM1, GM2 and NPC.     📰 You can read the full story here: https://lnkd.in/e8k8pmc5   #Biotech, #clinicaltrials, #investors, #GM1, #GM2, #NPC, #organoid, #worldsymposium, #Teamwork, #RareDiseases, #Azafaros

🧫🔍 Exciting Findings on Hydra's Cellular Behavior! 🌿 We're thrilled to share some fascinating observation matching with insights from a recent article on Hydra epithelium and its cellular mechanisms. The research discusses macropinocytosis—a versatile endocytic strategy that plays a role in nutrient acquisition, immune surveillance, and membrane remodeling. 🌀 Despite significant molecular characterization, much about how macropinocytosis is regulated in tissues remains unknown. ✨ Key Finding: The authors https://lnkd.in/gkbwjeS8 have identified a previously undescribed form of constitutive macropinocytosis in Hydra epithelium, revealing that tissue stretch might be a crucial regulator of this process! This suggests that constitutive macropinocytosis may be more widespread than we thought, potentially playing a significant role in membrane tensioning and tissue remodeling. 🧬 These findings add another layer of understanding to how Hydra can interact with its environment and adapt to changes—something that we also observed in our recent videos, where Hydra elongated its body to capture prey. Such remarkable adaptability highlights the complex and versatile mechanisms at play in these simple yet fascinating organisms. 🤯 📽️ Check out our recent posts to see Hydra in action and feel free to share your thoughts! #Hydra #Macropinocytosis #CellBiology #Endocytosis #LifeSciences #ResearchUpdate #Microbiology #ScienceInAction #TissueRemodeling #Biosciences